Scientific Articles

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Animal StudyIn VitroHighlighted

Sequential hydrogen-release implant for promoting the soft tissue integration through immunomodulatory and pro-remodeling coupling

MHID-5401653PMID: 413343742026Bioactive Materials

Yue Yuan, Zishuo Hou, Miaomiao Chen, Jingwei Yu, Minghao Zhou, Jiaxin Kang, et al.

The weaker soft tissue integration around implants compared to natural teeth poses a substantial challenge to the long-term success of implants. To enhance soft tissue integration, we develop an on-demand and long-lasting H2-releasing implant to achieve precise sequential regulation of the soft tissue integration through immunomodulation and pro-remodeling coupling. In the inflammatory phase, the

Human StudyHighlighted

A case of lung injury due to a hydrogen explosion caused by the simultaneous use of two home folk remedies devices

MHID-3244978PMID: 396343822024Acute Medicine & Surgery

Masato Tsuchikane, Takeshi Yamagiwa, Tadaaki Takada, Shinjiro Wakai, Sadaki Inokuchi

A 62-year-old woman was diagnosed with postoperative breast cancer recurrence. While inhaling hydrogen gas through a nasal cannula at home, she used a heat-therapy machine that emitted electromagnetic waves to the breast cancer site. She suddenly experienced explosive sounds in her chest and smelled burning. Subsequently, she experienced several overlapping hemoptysis episodes and was referred to

Mechanisms ReviewHighlighted

Mesenchymal Stem Cell Priming: Potential Benefits of Administration of Molecular Hydrogen

MHID-3162417PMID: 386754292024Pharmaceuticals

Mikhail Yu. Artamonov, Tyler W. LeBaron, Felix A. Pyatakovich, Inessa A. Minenko

Stem cell therapy has emerged as a promising avenue for regenerative medicine, offering the potential to treat a wide range of debilitating diseases and injuries. Among the various types of stem cells, mesenchymal stem cells (MSCs) have garnered significant attention due to their unique properties and therapeutic potential. In recent years, researchers have been exploring novel approaches to enhan

Literature ReviewOtherHighlighted

Guidelines for the selection of hydrogen gas inhalers based on hydrogen explosion accidents

MHID-7822057PMID: 362047812023Medical Gas Research

Yusuke Ichikawa, Shin-ichi Hirano, Bunpei Sato, Haru Yamamoto, Yoshiyasu Takefuji, Fumitake Satoh

Despite the fact that we have reported on the dangers of the explosion of hydrogen gas inhalers, hydrogen gas inhalers with explosive hazards are, as a matter of fact, still being sold today. In this study, we investigated past reports of hydrogen gas inhaler explosion accidents to clarify the causes of these explosion incidents. As a result of this investigation, we found that the central cause w

Literature ReviewHighlighted

Electrolyzed–Reduced Water: Review II: Safety Concerns and Effectiveness as a Source of Hydrogen Water

MHID-2004094PMID: 364988382022International Journal of Molecular Sciences

Tyler W. LeBaron, Randy Sharpe, Kinji Ohno

Many studies demonstrate the safety of alkaline-electrolyzed–reduced water (ERW); however, several animal studies have reported significant tissue damage and hyperkalemia after drinking ERW. The mechanism responsible for these results remains unknown but may be due to electrode degradation associated with the production of higher pH, in which platinum nanoparticles and other metals that have harmf

Animal StudyHighlighted

Protective Effects of Hydrogen against Low-Dose Long-Term Radiation-Induced Damage to the Behavioral Performances, Hematopoietic System, Genital System, and Splenic Lymphocytes in Mice

MHID-7644453PMID: 277741162016Oxidative Medicine and Cellular Longevity

Jiaming Guo, Deyun Zhao, Xiao Lei, Hainan Zhao, Yanyong Yang, Pei Zhang, et al.

Molecular hydrogen (H2) has been previously reported playing an important role in ameliorating damage caused by acute radiation. In this study, we investigated the effects of H2 on the alterations induced by low-dose long-term radiation (LDLTR). All the mice in hydrogen-treated or radiation-only groups received 0.1 Gy, 0.5 Gy, 1.0 Gy, and 2.0 Gy whole-body gamma radiation, respectively. After the