Hydrogen Protects Mice from Radiation Induced Thymic Lymphoma in BALB/c Mice

Abstract

Ionizing radiation (IR) is a well-known carcinogen, however the mechanism of radiation in- duced thymic lymphoma is not well known. Moreover, an easy and effective method to protect mice from radiation induced thymic lymphoma is still unknown. Hydrogen, or H2, is seldom regarded as an important agent in medical usage, especially as a therapeutic gas. Here in this study, we found that H2 protects mice from radiation induced thymic lymphoma in BALB/c mice.

Study details

Article type

Original Research

Disease / injury model

Radiation-induced thymic lymphoma (carcinogenesis)

Duration

30 weeks

Dose-dependent effect

No

Outcome

Positive

Findings

Hydrogen-rich saline administered before irradiation significantly increased survival, reduced thymic lymphoma incidence, and delayed tumor latency in BALB/c mice exposed to split-dose gamma irradiation. H2 also reduced ROS and MDA, and increased SOD and GSH levels, indicating enhanced antioxidant status.