Therapeutic effect of hydrogen and its mechanisms in kidney disease treatment

Abstract

Hydrogen is a simple, colorless, and biologically active small molecule gas that can react with reactive oxygen species. Recent research suggests that hydrogen possesses several biological effects, including antioxidant, anti-inflammatory, and anti-apoptotic effects, while exhibiting an extremely high level of safety. Hydrogen application has shown promise in treating a range of acute and chronic diseases, both benign and malignant. Importantly, an increasing number of clinical studies on hydrogen have demonstrated its efficacy and safety in treating various diseases. This review highlights the beneficial effects of hydrogen in kidney diseases, summarizes potential mechanisms by which hydrogen may act in these diseases, and proposes several promising avenues for future research.

Study details

Article type

Review

Disease / injury model

Various Kidney/Renal diseases are discussed

Dose-dependent effect

No

Outcome

Positive

Findings

H2 medicine is rapidly advancing and has unique advantagescompared to hydrogen sulfide and other cytotoxic antioxi-dants. H2 is safe and has strong diffusion ability, making it anattractive treatment method.