Animal StudyIn VitroHighlighted
MHID-9975059PMID: 394361892025Medical Gas Research
Wanqiu Chen, Yinyin Zhang, Gen Miao, Yajing Ying, Zifu Ren, Xuejun Sun, et al.
There is strong evidence connecting increased serum lipid levels to cardiovascular disorders, including atherosclerosis. Statins is prescribed as the primary medication to decrease lipid levels. Recent research has demonstrated that hydrogen possesses anti-inflammatory and antioxidant properties by modulating the expression of peroxisome proliferator-activated receptor gamma coactivator-1α, ultima
HypothesisOpinion PieceHighlighted
MHID-6155704PMID: 402510252025Medical Gas Research
Nikola Todorovic, Jovan Kuzmanovic, Dejan Javorac, Sergej M Ostojic
The increasing prevalence of obesity and non-communicable diseases has become a major global health concern, contributing to significant morbidity and mortality rates. These conditions not only burden healthcare systems but also affect the individual’s quality of life worldwide. As these challenges continue to grow, there is a pressing need to explore treatment options that are effective, affordab
Literature ReviewHighlighted
MHID-0845802PMID: 399115282025Biochemistry and Biophysics Reports
Fatmanur Yıldız, Tyler W. LeBaron, Duried Alwazeer
Oxidative stress is responsible for the pathogenesis of many diseases, and antioxidants are commonly included in their treatment protocols. Over the past two decades, numerous biomedical reports have revealed the therapeutic benefits of molecular hydrogen (H2) in relieving oxidation-related diseases. H2 has been found to have selective antioxidant properties against the most dangerous oxidants (hy
Animal StudyIn VitroEx VivoHighlighted
MHID-9370665PMID: 404119852025Biomaterials
Yuanming An, Lizhen Zheng, Shi’an Zhang, Haozhi Zhang, Yuantao Zhang, Hongwei Shao, et al.
Steroid-associated osteonecrosis (SAON) remains a challenging clinical condition as there are few effective preventive measures. This study investigates the effects of hydrogen (H2) administrated via saturated hydrogen-rich water (HRW) in mice received high dose of glucocorticoids (for inducing SAON model). Here we find that HRW treatment significantly reduces osteocyte apoptosis, improves deterio
Clinical TrialHighlighted
MHID-1498378PMID: 392581912024Heliyon
Fenglin Wu, Jun Ma, Junli Xue, Xue Jiang, Jinyu Liu, Jiashuo Zhang, et al.
Background: Consumption of hydrogen-rich water (HRW) has been shown to have anti- inflammatory and metabolic-modulatory benefits.
Objective: A randomized, placebo-controlled trial was conducted to assess the potential blood uric acid-lowering effects of HRW consumption with different doses (low and high doses) and duration (4 and 8 weeks) in patients with hyperuricemia.
Methods: The Placebo grou
Clinical TrialObservational StudyHighlighted
MHID-1663378PMID: 383995332024Medicina
Shih-Feng Liu, Chin-Ling Li, Hui-Ching Lee, Hui-Chuan Chang, Jui-Fang Liu, Ho-Chang Kuo
Background and Objectives: Recent studies suggest that hydrogen gas possesses anti-inflammatory, antioxidant, and anti-apoptotic properties. This study aimed to explore the therapeutic potential of hydrogen gas and assess its safety and tolerability in individuals with chronic obstructive pulmonary disease (COPD). Materials and Methods: Enrolled COPD patients received standard treatments along wit
Clinical TrialHighlighted
MHID-7984305PMID: 389082962024The Journal of Nutrition, Health and Aging
Sonja Baltic, David Nedeljkovic, Nikola Todorovic, Marijana Ranisavljev, Darinka Korovljev, Jelena Cvejic, et al.
Objectives: To assess the impact of medium-term supplementation with dihydrogen and pyrroloquinoline quinone (PQQ) on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals diagnosed with mild cognitive impairment.
Design: A parallel-group, randomized, placebo-controlled, double-blind experimental design, maintaining a 1:1 allocation ratio between the experimental group (
Clinical TrialHighlighted
MHID-2861044PMID: 383977432024Antioxidants
Reiko Moribe, Marina Minami, Ryoji Hirota, Naw Awn J-P, Shigeru Kabayama, Masamitsu Eitoku, et al.
We studied the effect of three months’ use of electrolyzed hydrogen water (EHW, Elec-
trolyzed Hydrogen Water conditioner produced by Nihon Trim Co., Ltd.) on metabolic and pre-
metabolic syndrome groups. This research was carried out jointly by Susaki City; Nihon Trim Co.,
Ltd.; and Kochi University as part of a local revitalization project with health as a keyword. A ran-
domized, placebo-contro
In VitroHighlighted
MHID-2493537PMID: 390620202024Biomedicines
Sing-Hua Tsou, Sheng-Chieh Lin, Wei-Jen Chen, Hui-Chih Hung, Chun-Cheng Liao, Edy Kornelius, et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by exces- sive fat accumulation in the liver. Intracellular oxidative stress induced by lipid accumulation leads to various hepatocellular injuries including fibrosis. However, no effective method for mitigating MASLD without substantial side effects currently exists. Molecular hydrogen (H2) has garnered attention du
Animal StudyHighlighted
MHID-9892485PMID: 388393612024Biological and Pharmaceutical Bulletin
Risako Morishita, Ayaka Onishi, Maresuke Oya, Hirotsugu Karashima, Misato Mori, Yuka Kawatani, et al.
Ultrafine bubbles (UFBs), which are bubbles with diameters of less than 1 µm, are widely recognized for their ability to exist stably in liquid as a result of the effects of Brownian motion. In this study, we focused on hydrogen, known for its antioxidant potential, and explored the function of H2-filled UFBs, which encapsulate hydrogen, to determine their potential use as oral carriers for the de
Observational StudyHighlighted
MHID-0293642PMID: 375214102023Frontiers in Nutrition
Szu-Han Chiu, Frank L. Douglas, Jia-Ru Chung, Kuang-Yih Wang, Chao-Fang Chu, Hsia-Yun Chou, et al.
Background: Metabolic syndrome is characterized by a cluster-like occurrence of conditions such as hypertension, hyperglycaemia, elevated low-density lipoprotein (LDL) cholesterol or triglycerides (TG) and high visceral fat. Metabolic syndrome is linked to the build-up of plaque within the artery, which leads to disorders of the circulatory, nervous and immune systems. A variety of treatments targ
Systematic ReviewHighlighted
MHID-32722772023Pharmaceuticals
Nikola Todorovic, Julen Fernández-Landa, Asier Santibañez, Branislav Kura, Valdemar Stajer, Darinka Korovljev, et al.
Over the last two decades, a plethora of disease models and human studies have confirmed the beneficial effects of molecular hydrogen (H2), a simple biotherapeutic gas. Recent small-scale studies evaluating the effects of hydrogen-rich water (HRW) on various metabolic conditions pointed to advantageous effects of HRW in regulating blood lipid profiles. However, to the best of the authors’ knowledge,
Clinical TrialHighlighted
MHID-7707676PMID: 375698502023International Journal of Molecular Sciences
Zuzana Sumbalova, Jarmila Kucharská, Zuzana Rausová, Anna Gvozdjakova, Mária Szántová, Branislav Kura, et al.
Molecular hydrogen (H2) has been recognized as a novel medical gas with antioxidant and anti-inflammatory effects. Non-alcoholic fatty liver disease (NAFLD) is a liver pathology with increased fat accumulation in liver tissue caused by factors other than alcohol consumption. Platelet mitochondrial function is considered to reflect systemic mitochondrial health. We studied the ef- fect of adjuvant th
Animal StudyIn VitroHighlighted
MHID-1279019PMID: 372155682023Theranostics
Geru Tao, Feng Liu, Zhaokui Jin, Boyan Liu, Hao Wang, Daosheng Li, et al.
Background: Chronic liver diseases (CLD) frequently derive from hepatic steatosis, inflammation and fibrosis, and become a leading inducement of cirrhosis and hepatocarcinoma. Molecular hydrogen (H2) is an emerging wide-spectrum anti-inflammatory molecule which is able to improve hepatic inflammation and metabolic dysfunction, and holds obvious advantages in biosafety over traditional anti-CLD dru
Animal Study
MHID-7818899PMID: 352644922022Experimental Animals
Kohei Kawakami, Hiroyuki Matsuo, Takaya Yamada, Ken-ichi Matsumoto, Daigoro Sasaki, Masato Nomura
Hydrogen-rich water (HW) has been suggested to possess antioxidant properties of value in treatments of lifestyle diseases and for prevention of latent pathologies. To date, the potential benefits of HW against the deleterious effects of excessive salt intake and hypertension have not been investigated. Here, we first examined the effects of HW or HW supplemented with 0.1% ascorbic acid (HWA) on s
Clinical TrialHighlighted
MHID-1269854PMID: 362782212022Frontiers in Pharmacology
Boyan Liu, Xue Jiang, Yunbo Xie, Xiubin Jia, Jiashuo Zhang, Yazhuo Xue, et al.
Objective: To explore the effect of a low-dose hydrogen–oxygen (H2-O2) mixture inhalation in midlife/older adults with hypertension.
Methods: This randomized, placebo-controlled trial included 60 participants with hypertension aged 50–70 years who were randomly divided into Air group (inhaled placebo air) or H2-O2 group [inhaled H2-O2 mixture (66% H2/33% O2)]. Participants in both groups were tre
Clinical TrialAnimal StudyIn VitroHighlighted
MHID-2649268PMID: 357349742022Journal of Cellular and Molecular Medicine
Geru Tao, Guangjie Zhang, Wei Chen, Chao Yang, Yazhuo Xue, Guohua Song, et al.
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide with increasing incidence consistent with obesity, type 2 diabetes and
cardiovascular diseases. No approved medication was currently available for NAFLD
treatment. Molecular hydrogen (H2), an anti-oxidative, anti-inflammatory biomedical
agent is proved to exhibit therapeutic and preventive effect in variou
Clinical TrialHighlighted
MHID-6639794PMID: 362906572022Antioxidants
Branislav Kura, Mária Szántová, Tyler W. LeBaron, Viliam Mojto, Miroslav Barancik, Barbara Szeiffova Bacova, et al.
Non-alcoholic fatty liver disease (NAFLD) is a liver pathology affecting around 25% of the population worldwide. Excess oxidative stress, inflammation and aberrant cellular signaling can lead to this hepatic dysfunction and eventual carcinoma. Molecular hydrogen has been recognized for its selective antioxidant properties and ability to attenuate inflammation and regulate cellular function. We admin
Clinical TrialHighlighted
MHID-5701846PMID: 322737402020Diabetes, Metabolic Syndrome and Obesity
Tyler W. LeBaron, Ram B. Singh, Ghizal Fatima, Kumar Kartikey, Jagdish P Sharma, Sergej M Ostojic, et al.
Purpose: Metabolic syndrome is associated with several medical risk factors including dyslipidemia, hyperglycemia, and obesity, which has become a worldwide pandemic. The sequelae of this condition increase the risk of cardiovascular and neurological disease and increased mortality. Its pathophysiology is associated with redox dysregulation, excessive inflammation, and perturbation of cellular hom
Animal StudyHighlighted
MHID-8428241PMID: 331161632020Scientific Reports
Zhi‑ming Xun, Qing‑hui Zhao, Yan Zhang, Fang‑di Ju, Jin He, Ting‑ting Yao, et al.
The potential therapeutic effects of molecular hydrogen (H2) have now been confirmed in various human and animal-disease models. However, the effects of H2 on the physiological function in a normal state have been largely neglected. Hydrogen-rich water (HRW) intake and hydrogen inhalation (HI) are the most common used methods for hydrogen administration, the difference in the effects between HRW i
