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Literature Review

Effects of Molecular Hydrogen in the Pathophysiology and Management of Cardiovascular and Metabolic Diseases

MHID-6342582PMID: 390776462024Reviews in Cardiovascular Medicine

Ram B. Singh, Zuzana Sumbalova, Ghizal Fatima, Viliam Mojto, Jan Fedacko, Alex Tarnava, et al.

Diet and lifestyle choices, notably the Western-type diet, are implicated in oxidative stress and inflammation, factors that elevate the risk of cardiovascular diseases (CVDs) and type 2 diabetes mellitus (T2DM). In contrast, the Mediterranean of diet, rich in antioxidants, appears to have protective effects against these risks. This article highlights the dual role of diet in generating molecular

OXIDATIVE MODIFICATION OF PROTEINS IN COLORECTAL CANCER UNDER THE INFLUENCE OF 5-FLUOROURACIL AND MOLECULAR HYDROGEN

MHID-44667412024Clinical and Experimental Pathology (Клінічна та експериментальна патологія)

O. O. Pokotylo, M. M. Korda

The aim of the study – to investigate the eff ect of water saturated with molecular hydrogen and 5-fl uorouracil on the content of carbonyl groups of oxidatively modifi ed proteins in the blood serum of white rats with colorectal cancer. Material and Methods. The experiments were conducted on 50 male Wistar rats. The animals were modeled with colorectal cancer (CRC) by subcutaneous injection of 1,2-d

Clinical TrialHighlighted

Molecular hydrogen exposure improves functional state of red blood cells in the early postoperative period: a randomized clinical study

MHID-8082099PMID: 362047842023Medical Gas Research

Anna Vaycheslavovna Deryugina, Darya Andreevna Danilova, Yurii Dmitrievich Brichkin, Evgenii Vladimirovich Taranov, Evgenii Ivanovich Nazarov, Vladimir Viktorovich Pichugin, et al.

Molecular hydrogen (H2) has been considered a preventive and therapeutic medical gas in numerous diseases. The study aimed to investigate the potential role of molecular hydrogen as a component of anesthesia in surgical treatment with cardiopulmonary bypass (CPB) of acquired valve defects on the functional state of red blood cells (RBC) and functional indicators of cardiac activity. This clinical

Clinical TrialObservational StudyHighlighted

Mechanism of influence of molecular hydrogen on the function of the proximal tubule of the nephron in irritatable bowel syndrome

MHID-99610682021Journal of Education, Health and Sport

Yurii Rohovyi, Volf Tsitrin, Yula Bilooka, Ludmila Arkchipova, Vyacheslav Bilookiy

Aim. To find out a pathophysiological protective role of influence of molecular hydrogen on a functional condition of a proximal tubule of kidneys at an irritable bowel syndrome. Materials and methods. 60 patients with irritable bowel syndrome were examined. Men - 18, women - 42 aged from 28 to 62 years. Of which: with irritable bowel syndrome with constipation were - 28 patients, irritable bowel

Clinical TrialObservational StudyHighlighted

Application of Molecular Hydrogen in Heart Surgery under Cardiopulmonary Bypass

MHID-5538038PMID: 345130692021Sovremennye tehnologii v medicine

D.A. Danilova, Yu.D. Brichkin, A.P. Medvedev, V.V. Pichugin, S.A. Fedorov, E.V. Taranov, et al.

The aim of this work was to study the effect of molecular hydrogen on oxidative processes in cardiac surgery patients with acquired valve heart disease applied during surgery under cardiopulmonary bypass (CPB). Materials and Methods. The study involved 20 patients (16 men and 4 women) with acquired heart valve disease who were operated on under CPB. Two groups of patients were formed. In group 1

Literature ReviewHighlighted

Homeostatic and endocrine responses as the basis for systemic therapy with medical gases: ozone, xenon and molecular hydrogen

MHID-5196947PMID: 342135002021Medical Gas Research

Eugene Iv. Nazarov, Igor Alb. Khlusov, Mami Noda

Among medical gases, including gases used therapeutically, this review discusses the comparative physiological activity of three gases – ozone (O3), xenon (Xe) and molecular hydrogen (H2), which together form representatives of three types of substances – typical oxidizing, inert, and typical reducing agents. Upon analysis of published and proprietary data, we concluded that these three medical ga