Animal StudyIn VitroHighlighted
MHID-6714009PMID: 283863422017American Journal of Translational Research
Cheng Li, Lengchen Hou, Dan Chen, Fuqing Lin, Tao Chang, Mengzhu Li, et al.
Objectives: The inhaled general anesthetic isoflurane has been shown to induce caspase-3 activation in vitro and in vivo. The underlying mechanisms and functional consequences of this activity remain unclear. Isoflurane can induce caspase-3 activation by causing accumulation of reactive oxygen species (ROS), mitochondrial dysfunction, and reduction in adenosine triphosphate (ATP) levels. This stud
Animal StudyIn VitroHighlighted
MHID-89507332012Medical Science Monitor
Yanyong Yang, Bailong Li, Cong Liu, Yunhai Chuai, Jixiao Lei, Fu Gao, et al.
Background: Radiation often causes depletion of immunocytes in tissues and blood, which results in immuno suppression. Molecular hydrogen (H2) has been shown in recent studies to have potential as a safe and effective radioprotective agent through scavenging free radicals. This study was designed to test the hypothesis that H2 could protect immunocytes from ionizing radiation (IR).
Material/Metho
Human StudyLiterature ReviewAnimal StudyIn VitroHighlighted
MHID-1756030PMID: 221460822011Medical Gas Research
Shigeo Ohta, Atsunori Nakao, Kinji Ohno
This report summarizes a brief description/history of the Hydrogen Research Meetings as well as key presentations/oral abstracts delivered in the most recent symposium. Additionally, we introduced 38 diseases and physiological states for which hydrogen exhibits beneficial effects.
In VitroHighlighted
MHID-98352102010Nuclear Technology & Radiation Protection
Liren Qian, Bailong Li, Fei CAO, Yuecheng Huang, Shulin Liu, Jianming Cai, et al.
Hydroxyl radicals play an important role in ionizing radiation-induced cellular damage, while hydrogen can selectively reduce hydroxyl radicals in vitro. This study was designed to test the hypothesis that hydrogen-rich PBS may be an effective radioprotective agent in vitro. Com pared to cells pretreated with out hydrogen, we demonstrated that treating cells with hydrogen-rich PBS be fore irradiat
Animal StudyIn VitroHighlighted
MHID-1312487PMID: 332312662010Free Radical Research
Liren Qian, Fei CAO, Jianguo Cui, Yuecheng Huang, Xiaojian Zhou, Shulin Liu, et al.
It has been demonstrated that hydrogen can selectively reduce hydroxyl and peroxynitrite in vitro. Since most of the ionizing radiation-induced cellular damage is caused by hydroxyl radicals, this study was designed to test the hypoth- esis that hydrogen may be an effective radioprotective agent. This paper demonstrates that treating cells with hydrogen before irradiation could signifi cantly inhib
In VitroHighlighted
MHID-9110946PMID: 210427402010Oncology Reports
Ryoko Asada, KATSUHIRO KAGEYAMA, HIROSHI TANAKA, HISAKAZU MATSUI, MASATSUGU KIMURA, Yasukazu Saitoh, et al.
In order to erase reactive oxygen species (ROS) related with the proliferation of tumor cells by reducing activity of hydrogen, we developed functional water containing nano-bubbles (diameters: <900 nm for 71%/ population) hydrogen of 1.1-1.5 ppm (the theoretical maximum: 1.6 ppm) with a reducing ability (an oxidation- reduction potential -650 mV, normal water: +100-200 mV) using a microporous-fil
Animal StudyIn VitroHighlighted
MHID-7700658PMID: 174860892007Nature Medicine
Ikuroh Ohsawa, Masahiro Ishikawa, Kumiko Takahashi, Megumi Watanabe, Kiyomi Nishimaki, Kumi Yamagata, et al.
Acute oxidative stress induced by ischemia-reperfusion or inflammation causes serious damage to tissues, and persistent oxidative stress is accepted as one of the causes of many common diseases including cancer. We show here that hydrogen (H2) has potential as an antioxidant in preventive and therapeutic applications. We induced acute oxidative stress in cultured cells by three independent methods.
