Animal StudyHighlighted
MHID-6449583PMID: 412075402026Journal of Nutritional Biochemistry
Naomi Kamimura, Katsuya Iuchi, Tsutomu Igarashi, Ikuroh Ohsawa, Chikako Nito, Jitsuo Usuda, et al.
Acetaminophen (APAP) overdose induces severe liver injury, especially in diabetic patients. N -acetylcysteine (NAC) is commonly used as an approved an- tidote for APAP toxicity; however, its narrow therapeutic window limits its clinical utility. This study investigated the protective effects of molecular hydro- gen (H2 ) against APAP-induced hepatotoxicity in diabetic mice. Diabetic db/db mice wer
Animal StudyIn VitroHighlighted
MHID-9975059PMID: 394361892025Medical Gas Research
Wanqiu Chen, Yinyin Zhang, Gen Miao, Yajing Ying, Zifu Ren, Xuejun Sun, et al.
There is strong evidence connecting increased serum lipid levels to cardiovascular disorders, including atherosclerosis. Statins is prescribed as the primary medication to decrease lipid levels. Recent research has demonstrated that hydrogen possesses anti-inflammatory and antioxidant properties by modulating the expression of peroxisome proliferator-activated receptor gamma coactivator-1α, ultima
Literature ReviewHighlighted
MHID-0845802PMID: 399115282025Biochemistry and Biophysics Reports
Fatmanur Yıldız, Tyler W. LeBaron, Duried Alwazeer
Oxidative stress is responsible for the pathogenesis of many diseases, and antioxidants are commonly included in their treatment protocols. Over the past two decades, numerous biomedical reports have revealed the therapeutic benefits of molecular hydrogen (H2) in relieving oxidation-related diseases. H2 has been found to have selective antioxidant properties against the most dangerous oxidants (hy
Literature ReviewHighlighted
MHID-44233202024Molecular Hydrogen in Health and Disease, Advances in Biochemistry in Health and Disease
Shin-ichi Hirano, Yusuke Ichikawa, Bunpei Sato, Yoshiyasu Takefuji, Xiao-Kang Li, Fumitake Satoh
Mitochondria originated from aerobic bacteria in endosymbiosis. Through this symbiosis, eukaryotes acquired an efficient energy-producing system, but at the cost of exposure to oxidative stress from reactive oxygen species (ROS). Molecular hydrogen (H2) was recently identified as an antioxidant that selectively reduces ROS, such as hydroxyl radicals and peroxynitrite, which are strong oxidants, and
Meta-AnalysisHypothesisHighlighted
MHID-1049920PMID: 404064272024Gastroenterology and Hepatology From Bed to Bench
Ghazaleh Khalili-Tanha, Hamid Jamialahmadi, Mostafa Rezaei-Tavirani, Elham Nazari
Aim: This systematic review and meta-analysis aimed to assess the effect of hydrogen-rich water (HRW) on liver enzyme levels.
Background: Liver disease is a significant global health concern, greatly affecting mortality rates. Elevated levels of liver enzymes, such as ALT, AST, ALP, and GGT are early symptoms of liver disorders, and various approaches can help reduce them. Recent studies have sho
In VitroHighlighted
MHID-2493537PMID: 390620202024Biomedicines
Sing-Hua Tsou, Sheng-Chieh Lin, Wei-Jen Chen, Hui-Chih Hung, Chun-Cheng Liao, Edy Kornelius, et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by exces- sive fat accumulation in the liver. Intracellular oxidative stress induced by lipid accumulation leads to various hepatocellular injuries including fibrosis. However, no effective method for mitigating MASLD without substantial side effects currently exists. Molecular hydrogen (H2) has garnered attention du
Animal StudyHighlighted
MHID-9892485PMID: 388393612024Biological and Pharmaceutical Bulletin
Risako Morishita, Ayaka Onishi, Maresuke Oya, Hirotsugu Karashima, Misato Mori, Yuka Kawatani, et al.
Ultrafine bubbles (UFBs), which are bubbles with diameters of less than 1 µm, are widely recognized for their ability to exist stably in liquid as a result of the effects of Brownian motion. In this study, we focused on hydrogen, known for its antioxidant potential, and explored the function of H2-filled UFBs, which encapsulate hydrogen, to determine their potential use as oral carriers for the de
Clinical TrialHighlighted
MHID-7707676PMID: 375698502023International Journal of Molecular Sciences
Zuzana Sumbalova, Jarmila Kucharská, Zuzana Rausová, Anna Gvozdjakova, Mária Szántová, Branislav Kura, et al.
Molecular hydrogen (H2) has been recognized as a novel medical gas with antioxidant and anti-inflammatory effects. Non-alcoholic fatty liver disease (NAFLD) is a liver pathology with increased fat accumulation in liver tissue caused by factors other than alcohol consumption. Platelet mitochondrial function is considered to reflect systemic mitochondrial health. We studied the ef- fect of adjuvant th
Clinical TrialHighlighted
MHID-6639794PMID: 362906572022Antioxidants
Branislav Kura, Mária Szántová, Tyler W. LeBaron, Viliam Mojto, Miroslav Barancik, Barbara Szeiffova Bacova, et al.
Non-alcoholic fatty liver disease (NAFLD) is a liver pathology affecting around 25% of the population worldwide. Excess oxidative stress, inflammation and aberrant cellular signaling can lead to this hepatic dysfunction and eventual carcinoma. Molecular hydrogen has been recognized for its selective antioxidant properties and ability to attenuate inflammation and regulate cellular function. We admin
Animal StudyHighlighted
MHID-2655528PMID: 352732492022Scientific Reports
Yao Mawulikplimi Adzavon, Fei Xie, Yang Yi, Xue Jiang, Xiaokang Zhang, Jin He, et al.
Molecular hydrogen (H2) has emerged as a new therapeutic option in several diseases and is widely adopted by healthy people. However, molecular data to support therapeutic functions attributed to the biological activities of H2 remain elusive. Here, using transcriptomic and metabolomic approaches coupled with biochemistry and micro-CT technics, we evaluated the effect of long-term (6 months) and d
Literature Review
MHID-5326803PMID: 349874192021Frontiers in Physiology
Yan Tian, Yafang Zhang, Yu Wang, Yunxi Chen, Weiping Fan, Jianjun Zhou, et al.
Molecular hydrogen (H2) is a colorless and odorless gas. Studies have shown that H2 inhalation has the therapeutic effects in many animal studies and clinical trials, and its application is recommended in the novel coronavirus pneumonia treatment guidelines in China recently. H2 has a relatively small molecular mass, which helps it quickly spread and penetrate cell membranes to exert a wide range
Animal StudyIn VitroHighlighted
MHID-2423362PMID: 334391022021American Journal of Physiology - Gastrointestinal and Liver Physiology
Shao-Wei Li, Terumi Takahara, Weitao Que, Masayuki Fujino, Wen-Zhi Guo, Shin-ichi Hirano, et al.
Nonalcoholic steatohepatitis (NASH) could progress to hepatic fibrosis in the absence of effective control. The purpose of our experiment was to investigate the protective effect of drinking water with a high concentration of hydrogen, namely, hydrogen-rich water (HRW), on mice with nonalcoholic fatty liver disease to elucidate the mechanism underlying the therapeutic action of molecular hydrogen.
Clinical TrialHighlighted
MHID-9688108PMID: 309827482019Clinics and Research in Hepatology and Gastroenterology
Darinka Korovljev, Valdemar Stajer, Jelena Ostojic, Tyler W. LeBaron, Sergej M Ostojic
Background and aims: While non-alcoholic fatty liver disease (NAFLD) is rapidly becoming the most common liver disease worldwide, its treatment remains elusive. Since metabolic impairment plays a major role in NAFLD pathogenesis, any pharmaceuticals, such as molecular hydrogen (H2), that advance lipid and glucose metabolism could be appropriate to tackle this complex condition. The aim of this stu
Animal StudyIn VitroHighlighted
MHID-6163351PMID: 305683872018World Journal of Gastroenterology
Karen Jackson, Noa Dressler, Rotem S Ben-Shushan, Ari Meerson, Tyler W. LeBaron, Snait Tamir
AIM To identify the effect of hydrogen-rich water (HRW) and electrolyzed-alkaline water (EAW) on high-fat-induced non-alcoholic fatty acid disease in mice.
METHODS Mice were divided into four groups: (1) Regular diet (RD)/regular water (RW); (2) high-fat diet (HFD)/RW; (3) RD/EAW; and (4) HFD/EAW. Weight and body composition were measured. After twelve weeks, animals were sacrificed, and livers w
Animal StudyIn VitroHighlighted
MHID-7490434PMID: 287851462017World Journal of Gastroenterology
Ching-Pin Lin, Wen-Chen Chuang, Fung-Jou Lu, Chih-Yen Chen
AIM To investigate the effects of hydrogen-rich water (HRW) treatment on prevention of ethanol (EtOH)-induced early fatty liver in mice.
METHODS In vitro reduction of hydrogen peroxide by HRW was determined with a chemiluminescence system. Female mice were randomly divided into five groups: control, EtOH, EtOH + silymarin, EtOH + HRW and EtOH + silymarin + HRW. Each group was fed a Lieber-DeCarli
Literature ReviewHighlighted
MHID-7479916PMID: 264839532015Medical Gas Research
Masatoshi Ichihara, Sayaka Sobue, Mikako Ito, Masafumi Ito, Masaaki Hirayama, Kinji Ohno
Therapeutic effects of molecular hydrogen for a wide range of disease models and human diseases have been investigated since 2007. A total of 321 original articles have been published from 2007 to June 2015. Most studies have been conducted in Japan, China, and the USA. About three-quarters of the articles show the effects in mice and rats. The number of clinical trials is increasing every year. I
Human StudyLiterature ReviewAnimal StudyIn VitroHighlighted
MHID-1756030PMID: 221460822011Medical Gas Research
Shigeo Ohta, Atsunori Nakao, Kinji Ohno
This report summarizes a brief description/history of the Hydrogen Research Meetings as well as key presentations/oral abstracts delivered in the most recent symposium. Additionally, we introduced 38 diseases and physiological states for which hydrogen exhibits beneficial effects.
