Observational StudyHighlighted
MHID-3602984PMID: 312492542019Medical Gas Research
Ryoko Asada, Yasukazu Saitoh, Nobuhiko Miwa
Hydrogen-dissolved water has been shown to improve diverse oxidation stress-related diseases, which drove us to examine effects of hydrogen-rich water on oxidation stress-related skin troubles and lipid-metabolism markers. The purpose of this study is whether the dissolved hydrogen in hydrogen-rich water was kept even after boiling, and whether hydrogen-bath utilization improves cosmetic effects s
Literature Review
MHID-31863052018Asia-Pacific Journal of Blood Types and Genes
Jinqi Li, Yan Zang, Haihui Gu, Baohua Qian
Hydrogen (H2) is a colorless, odorless gas that can act as a reducing agent under certain circumstances. Previously considered physiologically an inert and nonfunctional molecule in mammalian cells, H2 largely went ignored until Nature Medicine revealed the antioxidant and cytoprotective effects of hydrogen gas in a focal stroke model. Reactive oxygen species (ROS) is generated inside the body thr
Literature Review
MHID-5774686PMID: 301278612018Oncology Letters
Ye Yang, Yaping Zhu, Xiaowei Xi
Hydrogen (H2) has advantages that lead it to be
used as a novel antioxidant in preventive and therapeutic
applications. H2 can permeate into biomembranes, cytosol,
mitochondria and nuclei, and can be dissolved in water or
saline to produce H2 water or H2‑rich saline. H2 selectively
reduces oxidants of the detrimental reactive oxygen species
(ROS), including hydroxyl radicals (·OH) and peroxynitrit
Literature ReviewOpinion Piece
MHID-2698536PMID: 280038792016F1000Research
Sergej M Ostojic
Molecular hydrogen (H ) has recently been recognized as a potential novel therapeutic agent in biomedicine. Initially proposed to be a possible treatment for certain types of neuromuscular disorders, cardio-metabolic diseases and cancer, H improved clinical end-points and surrogate markers in several clinical trials, mainly acting as an anti-inflammatory agent and powerful antioxidant. In this pap
Literature Review
MHID-7427440PMID: 255259532015International Journal of Sports Medicine
S. M. Ostojic
In the past 2 decades, molecular hydrogen emerged as a novel therapeutic agent, with anti-oxidant, anti-inflammatory and anti-apoptotic effects demonstrated in plethora of animal disease models and human studies. Beneficial effects of molecular hydrogen in clinical environment are observed especially in oxidative stress-mediated diseases, such as diabetes mellitus, brain stem infarction, rheumatoi
Literature Review
MHID-0477754PMID: 247690812014Pharmacology & Therapeutics
Shigeo Ohta
Molecular hydrogen (H2) has been accepted to be an inert and nonfunctional molecule in our body. We have turned this concept by demonstrating that H2 reacts with strong oxidants such as hydroxyl radical in cells, and proposed its potential for preventive and therapeutic applications. H2 has a number of advantages exhibiting extensive effects: H2 rapidly diffuses into tissues and cells, and it is m
Clinical TrialHighlighted
MHID-29235562014Sports medicine / News in Molecular Hydrogen Biomedicine
Sergej M Ostojic, Boris Vukomanovic, Julio Calleja-Gonzalez, Jay R Hoffman
Background: Because hydrogen therapy has been found beneficial for the treatment of inflammation, ischemia-reperfusion injury, and oxidative stress in humans, it seems useful to evaluate the effects of exogenously administered hydrogen as an element in the immediate management of sports-related soft tissue injuries. The main aim of this pilot study was to examine the effects of 2-week administrati
Literature Review
MHID-0878205PMID: 236800322013Medical Gas Research
Brandon J Dixon, Jiping Tang, John H Zhang
Studies on molecular hydrogen have evolved tremendously from its humble beginnings and have continued to change throughout the years. Hydrogen is extremely unique since it has the capability to act at the cellular level. Hydrogen is qualified to cross the blood brain barrier, to enter the mitochondria, and even has the ability to translocate to the nucleus under certain conditions. Once in these i
Literature Review
MHID-8352354PMID: 216215882012Biochimica et Biophysica Acta
Shigeo Ohta
Background: Mitochondria are the major source of oxidative stress. Acute oxidative stress causes serious damage to tissues, and persistent oxidative stress is one of the causes of many common diseases, cancer and the aging process; however, there has been little success in developing an effective antioxidant with no side effect. We have reported that molecular hydrogen has potential as an effectiv
Animal StudyHighlighted
MHID-2488306PMID: 220408782011Biological & Pharmaceutical Bulletin
Kyung Su YOON, Xue Zhu HUANG, Yang Suk YOON, Soo-Ki Kim, Soon Bong SONG, Byung Soo CHANG, et al.
Electrolyzed reduced water (ERW), functional water, has various beneficial effects via antioxidant mecha-
nism in vivo and in vitro. However there is no study about beneficial effects of ERW bathing. This study aimed to
determine the effect of ERW bathing on the UVB-induced skin injury in hairless mice. For this purpose, mice
were irradiated with UVB to cause skin injury, followed by individually ta
Human StudyLiterature ReviewAnimal StudyIn VitroHighlighted
MHID-1756030PMID: 221460822011Medical Gas Research
Shigeo Ohta, Atsunori Nakao, Kinji Ohno
This report summarizes a brief description/history of the Hydrogen Research Meetings as well as key presentations/oral abstracts delivered in the most recent symposium. Additionally, we introduced 38 diseases and physiological states for which hydrogen exhibits beneficial effects.
In VitroObservational Study
MHID-9621518PMID: 220709002011Journal of Photochemistry and Photobiology B: Biology
Shinya Kato, Yasukazu Saitoh, Keizou Iwai, Nobuhiko Miwa
Hydrogen-rich electrolyzed warm water (HW) was prepared at 41ºC and exhibited dissolved hydrogen (DH) of 1.13 ppm and an oxidation-reduction potential (ORP) of -741 mV in contrast to below 0.01 ppm and +184 mV for regular warm water (RW).
Fibroblasts OUMS-36 and keratinocytes HaCaT were used to examine effects of HW against UVA-ray irradiation. Type-I collagen was synthesized 1.85- to 2.03-fold m
Animal StudyHighlighted
MHID-7978470PMID: 198340322010Investigative Ophthalmology & Visual Science
Hideaki Oharazawa, Tsutomu Igarashi, Takashi Yokota, Hiroaki Fujii, Hisaharu Suzuki, Mitsuru Machide, et al.
PURPOSE. Retinal ischemia-reperfusion (I/R) injury by transient
elevation of intraocular pressure (IOP) is known to induce
neuronal damage through the generation of reactive oxygen
species. Study results have indicated that molecular hydrogen
(H2) is an efficient antioxidant gas that selectively reduces the
hydroxyl radical (OH) and suppresses oxidative stress-induced
injury in several organs. This
