Animal StudyHighlighted
MHID-1506377PMID: 363585252022Antioxidants
Santiago Coral-Pérez, Ignacio Martínez-Martel, Maria Martínez-Serrat, Gerard Batallé, Xue Bai, Christie R. A. Leite-Panissi, et al.
Chronic inflammatory pain is manifested in many diseases. The potential use of molecular hydrogen (H2) as a new therapy for neurological disorders has been demonstrated. Recent studies prove its analgesic properties in animals with neuropathic pain, but the possible antinociceptive, antidepressant, and/or anxiolytic actions of H2 during persistent inflammatory pain have not been investigated. Theref
Literature ReviewOpinion PieceHighlighted
MHID-7464677PMID: 340520182022The Journal of Thoracic and Cardiovascular Surgery
John N. Kheir, MD, James A. DiNardo, MD
Diatomic hydrogen (H2) is the lightest and most abundant molecule in the universe. Hydrogen's reactivity with oxygen is well recognized as a thermodynamically favorable redox reaction that forms water. H2's small size results in unsurpassed diffusivity (even diffusing through steel), enabling it to reach therapeutic targets effectively even in low-flow states. In vivo, inhaled H2 undergoes solubil
Animal StudyHighlighted
MHID-9667503PMID: 349703492022Experimental and Therapeutic Medicine
Yun Hu, Xiaoyan Feng, Junhui Chen, Yan Wu, Liuyan Shen
Traumatic brain injury (TBI) has been recognized as a serious public health issue and a key contributor to disability and death, with a huge economic burden worldwide. Hydrogen, which is a slight and specific cytotoxic oxygen radical scav‑enger, has been demonstrated to ameliorate early brain injury (EBI) through reactive oxygen species (ROS), oxidative stress injury, apoptosis and necroptosis. Ne
Animal StudyHighlighted
MHID-2919108PMID: 349481072021International Journal of Molecular Sciences
Eun-Sook Jeong, Johny Bajgai, In-Soo You, Md. Habibur Rahman, Ailyn Fadriquela, Subham Sharma, et al.
Oxidative stress (OS) is one of the causative factors in the pathogenesis of various neurode- generative diseases, including Alzheimer’s disease (AD) and cognitive dysfunction. In the present study, we investigated the effects of hydrogen (H2) gas inhalation in trimethyltin (TMT)-induced neurotoxicity and cognitive dysfunction in the C57BL/6 mice. First, mice were divided into the following groups
Observational StudyHighlighted
MHID-6285582PMID: 346451002021Journal of Integrative Neuroscience
Tyler W. LeBaron, Jason Kharman, Michael L. McCullough
Traumatic brain injuries (TBIs) are a leading cause of death and dis- ability. Sports-related TBIs are estimated to be more than several million per year. The pathophysiology of TBIs involves high levels of inflammation, oxidative stress, dysregulation of ion homeosta- sis, mitochondrial dysfunction, and apoptosis. There is also a reduc- tion in cerebral blood flow, leading to hypoxia and reduced
Literature ReviewHighlighted
MHID-9435089PMID: 330767982021Current Pharmaceutical Design
Mami Noda, Jiankang Liu, Jiangang Long
One of the beneficial effects of molecular hydrogen (H2, hydrogen gas) is neuroprotection and pre- vention of neurological disorders. It is important and useful if taking H2 every day can prevent or ameliorate the progression of neurodegenerative disorders, such as Parkinson’s disease or Alzheimer’s disease, both lacking specific therapeutic drugs. There are several mechanisms of how H2 protects n
Literature Review
MHID-9272690PMID: 330783742021Neuroscience Bulletin
Wei Chen, Han-Ting Zhang, Shu-Cun Qin
Molecular hydrogen (H2) is a physiologically inert gas. However, during the last 10 years, increasing evidence has revealed its biological functions under pathological conditions. More specifically, H2 has protec- tive effects against a variety of diseases, particularly nervous system disorders, which include ischemia/reperfu- sion injury, traumatic injury, subarachnoid hemorrhage, neuropathic pain
Clinical TrialHighlighted
MHID-9740359PMID: 345320232021Food Science & Nutrition
Nikola Todorovic, Dragana Zanini, Valdemar Stajer, Darinka Korovljev, Jelena Ostojic, Sergej M Ostojic
The main aim of this randomized-controlled cross-over interventional trial was to assess the acute effects of taking a single dose of hydrogen-rich water (HRW), and compare it with caffeine, HRW plus caffeine, and control water, for alertness, brain metabolism, brain and oxygen saturation, and self-reported adverse events in healthy men and women who were habitual coffee drinkers and were sleep-de
Mechanisms ReviewHighlighted
MHID-2592715PMID: 351026012020Antioxidants
Miroslav Barancik, Branislav Kura, Tyler W. LeBaron, Roberto Bolli, Jozef Buday, Jan Slezak
The increased production of reactive oxygen species and oxidative stress are important factors contributing to the development of diseases of the cardiovascular and central nervous systems. Molecular hydrogen is recognized as an emerging therapeutic, and its positive effects in the treatment of pathologies have been documented in both experimental and clinical studies. The therapeutic potential of
Literature ReviewMeta-Analysis
MHID-7985788PMID: 328266282020Current Opinion in Anesthesiology
Zhen Wang, Guolin Wang, Keliang Xie
Purpose of review: The current systematic review summarizes recent, basic clinical achievements regarding the neuroprotective effects of molecular hydrogen in distinct central nervous system conditions.
Recent findings: Perioperative neuroprotection remains a major topic of clinical anesthesia. Various gaseous molecules have previously been explored as a feasible therapeutic option in neurologica
Animal Study
MHID-1878579PMID: 322460952020Scientific Reports
Yuki Kobayashi, Ryoichi Imamura, Yoshihisa Koyama, Makoto Kondo, Hikaru Kobayashi, Norio Nonomura, et al.
We have developed Si-based agent which can generate a large amount of hydrogen. Si-based agent continues generating hydrogen for more than 24 h by the reaction with water under conditions similar to those in bowels, i.e., pH8.3 and 36 °C, and generates ~400 mL hydrogen. To investigate beneficial effects for diseases associated with oxidative stress, Si-based agent is administered to remnant kidney
Observational StudyHighlighted
MHID-9389875PMID: 325959372019F1000Research
Dejan Javorac, Valdemar Stajer, Sergej M Ostojic
Sport-related mild traumatic brain injury (TBI) is a serious
Background:
trauma that could impair brain function of an injured athlete. Treatment
solutions for mild TBI typically concentrate on complete rest, while
non-traditional therapeutic options remain largely ineffective. Molecular
hydrogen (H ) is an innovative neuroprotective agent that can easily reach
the brain, yet no data are available
Animal StudyHighlighted
MHID-8554516PMID: 310619202019JACC: Basic to Translational Science
Alexis R. Cole, BS, Dorothy A. Perry, MBCHB, Ali Raza, MD, Arthur P. Nedder, DVM, Elizabeth Pollack, DVM CANDIDATE, William L. Regan, CCP, LP, et al.
This study used a swine model of mildly hypothermic prolonged circulatory arrest and found that the addition of 2.4% inhaled hydrogen gas to inspiratory gases during and after the ischemic insult significantly decreased neurologic and renal injury compared with controls. With proper precautions, inhalational hydrogen may be administered safely through conventional ventilators and may represent a co
Literature Review
MHID-8766047PMID: 311002032019Canadian Journal of Physiology and Pharmacology
Mami Noda, Yuya Uemura, Yusuke Yoshii, Taichi Horita, Shota Takemi, Ichiro Sakata, et al.
Molecular hydrogen (H2) showed protection against various kinds of oxidative stress-
related diseases. First it was reported that the mechanism of therapeutic effects of H2 was
anti-oxidative effect due to inhibition of most cytotoxic reactive oxygen species (ROS),
hydroxy radical (•OH). However, after chronic administration of H2 in drinking water,
oxidative stress-induced nerve injury is signifi
Animal Study
MHID-4869388PMID: 316002562019PLoS ONE
Laura Bordoni, Rosita Gabbianelli, Donatella Fedeli, Dennis Fiorini, Ina Bergheim, Cheng Jun Jin, et al.
There is growing awareness within the scientific community of the strong connection between the inflammation in the intestine and the pathogenesis of Parkinson’s disease (PD). In previous studies we developed a PD animal model exposing pup rats to permethrin (PERM) pesticide. Here, we intended to explore whether in our animal model there were changes in gut permeability, fecal microbiota and hepat
In VitroIn SilicoHighlighted
MHID-67149392018PLoS ONE
Anzu Suzuki, Mikako Ito, Tomonori Hamaguchi, Hiroshi Mori, Yuka Takeda, Ryuko Baba, et al.
Oral administration of hydrogen water ameliorates Parkinson’s disease (PD) in rats, mice, and humans. We previously reported that the number of putative hydrogen-producing bacte- ria in intestinal microbiota is low in PD compared to controls. We also reported that the amount of hydrogen produced by ingestion of lactulose is low in PD patients. The decreased hydrogen production by intestinal microb
Clinical Trial
MHID-0476956PMID: 307136662018Medical Gas Research
Masaaki Hirayama, Mikako Ito, Tomomi Minato, Asako Yoritaka, Tyler W. LeBaron, Kinji Ohno
Hyposmia is one of the earliest and the most common symptoms in Parkinson’s disease (PD). The benefits of hydrogen water on motor deficits have been reported in animal PD models and PD patients, but the effects of hydrogen gas on PD patients have not been studied. We evaluated the effect of inhalation of hydrogen gas on olfactory function, non-motor symptoms, activities of daily living, and urinar
Animal StudyHighlighted
MHID-7672684PMID: 301277282018Frontiers in Behavioral Neuroscience
Qingjun Guo, Xi Yin, Meng Qiao, Yujiao Jia, Dandan Chen, Juan Shao, et al.
Due to its anti-inflammatory and anti-oxidative effects, recent research has demonstrated that molecular hydrogen can serve as a new medical approach for depression, anxiety and traumatic brain injury. However, its potential effects on neurodevelopmental diseases, such as autism are still elusive. The present study aims to investigate the potential effects of hydrogen-rich water (HRW) administratio
Literature Review
MHID-31863052018Asia-Pacific Journal of Blood Types and Genes
Jinqi Li, Yan Zang, Haihui Gu, Baohua Qian
Hydrogen (H2) is a colorless, odorless gas that can act as a reducing agent under certain circumstances. Previously considered physiologically an inert and nonfunctional molecule in mammalian cells, H2 largely went ignored until Nature Medicine revealed the antioxidant and cytoprotective effects of hydrogen gas in a focal stroke model. Reactive oxygen species (ROS) is generated inside the body thr
Clinical TrialAnimal StudyHighlighted
MHID-5385411PMID: 291106152018Current Alzheimer Research
Kiyomi Nishimaki, Takashi Asada, Ikuroh Ohsawa, Etsuko Nakajima, Chiaki Ikejima, Takashi Yokota, et al.
Background: Oxidative stress is one of the causative factors in the pathogenesis of neurodegenerative diseases including mild cognitive impairment (MCI) and dementia. We previously reported that molecular hydrogen (H2) acts as a therapeutic and preventive antioxidant.
Objective: We assess the effects of drinking H2-water (water infused with H2) on oxidative stress model mice and subjects with MCI
