Human StudyLiterature ReviewAnimal StudyIn VitroHighlighted
MHID-1756030PMID: 221460822011Medical Gas Research
Shigeo Ohta, Atsunori Nakao, Kinji Ohno
This report summarizes a brief description/history of the Hydrogen Research Meetings as well as key presentations/oral abstracts delivered in the most recent symposium. Additionally, we introduced 38 diseases and physiological states for which hydrogen exhibits beneficial effects.
Clinical TrialHighlighted
MHID-2481572PMID: 221466742011Medical Gas Research
Mikako Ito, Tohru Ibi, Ko Sahashi, Masashi Ichihara, Masafumi Ito, Kinji Ohno
Background: Molecular hydrogen has prominent effects on more than 30 animal models especially of oxidative stress-mediated diseases and inflammatory diseases. In addition, hydrogen effects on humans have been reported in diabetes mellitus type 2, hemodialysis, metabolic syndrome, radiotherapy for liver cancer, and brain stem infarction. Hydrogen effects are ascribed to specific radical-scavenging
Animal StudyIn VitroHighlighted
MHID-1458727PMID: 217232542011Biochemical and Biophysical Research Communications
Tomohiro Itoh, Nanako Hamada, Riyako Terazawa, Mikako Ito, Kinji Ohno, Masatoshi Ichihara, et al.
Molecular hydrogen has been reported to be effective for a variety of disorders and its effects have been ascribed to the reduction of oxidative stress. However, we have recently demonstrated that hydrogen inhibits type I allergy through modulating intracellular signal transduction. In the present study, we examined the hydrogen effects on lipopolysaccharide/interferon c LPS/IFNc-induced nitric ox
Animal StudyHighlighted
MHID-2760312PMID: 221460832011Medical Gas Research
Michio Hashimoto, Masanori Katakura, Toru Nabika, Yoko Tanabe, Shahdat Hossain, Satoru Tsuchikura, et al.
Background: Hydrogen (H2), a potent free radical scavenger, selectively reduces the hydroxyl radical, which is the most cytotoxic of the reactive oxygen species (ROS). An increase in oxygen free radicals induces oxidative stress, which is known to be involved in the development of metabolic syndrome. Therefore, we investigated whether hydrogen-rich water (HRW) affects metabolic abnormalities in th
In VitroHighlighted
MHID-98352102010Nuclear Technology & Radiation Protection
Liren Qian, Bailong Li, Fei CAO, Yuecheng Huang, Shulin Liu, Jianming Cai, et al.
Hydroxyl radicals play an important role in ionizing radiation-induced cellular damage, while hydrogen can selectively reduce hydroxyl radicals in vitro. This study was designed to test the hypothesis that hydrogen-rich PBS may be an effective radioprotective agent in vitro. Com pared to cells pretreated with out hydrogen, we demonstrated that treating cells with hydrogen-rich PBS be fore irradiat
HypothesisHighlighted
MHID-5193561PMID: 196648842010Medical Hypotheses
Cong Liu, Jianguo Cui, Quan Sun, Jianming Cai
Hydrogen is the most abundant chemical element in the universe, however, it is seldom regarded as a therapeutic gas. Recent studies show that inhaled hydrogen gas (H2) has antioxidant and antiapoptotic activities that protect the brain against ischemia–reperfusion injury and stroke by selectively reducing hydroxyl and peroxynitrite radicals. It is also well known that more than a half of the ioniz
Animal StudyIn VitroHighlighted
MHID-1312487PMID: 332312662010Free Radical Research
Liren Qian, Fei CAO, Jianguo Cui, Yuecheng Huang, Xiaojian Zhou, Shulin Liu, et al.
It has been demonstrated that hydrogen can selectively reduce hydroxyl and peroxynitrite in vitro. Since most of the ionizing radiation-induced cellular damage is caused by hydroxyl radicals, this study was designed to test the hypoth- esis that hydrogen may be an effective radioprotective agent. This paper demonstrates that treating cells with hydrogen before irradiation could signifi cantly inhib
Animal StudyHighlighted
MHID-2859819PMID: 211161022010Journal of Radiation Research
Liren Qian, Fei CAO, Jianguo Cui, Yicun Wang, Yuecheng Huang, Yunhai Chuai, et al.
Most ionizing radiation-induced damage is caused by hydroxyl radicals, and the selective reduction
of hydroxyl by hydrogen in vitro has been demonstrated previously. Irradiation of the heart can cause
chronic cardiac disease. This study was designed to test the hypothesis that hydrogen-rich water (pure
water saturated with molecular hydrogen), which is easy to use, induces cardioprotection against
Clinical TrialObservational StudyHighlighted
MHID-8766045PMID: 202169472010Journal of Clinical Biochemistry and Nutrition
Atsunori Nakao, Yoshiya Toyoda, Prachi Sharma, Malkanthi Evans, Najla Guthrie
Metabolic syndrome is characterized by cardiometabolic risk factors that include obesity, insulin resistance, hypertension and dyslipidemia. Oxidative stress is known to play a major role in the pathogenesis of metabolic syndrome. The objective of this study was to examine the effectiveness of hydrogen rich water (1.5–2 L/day) in an open label, 8-week study on 20 subjects with potential metabolic
Animal StudyHighlighted
MHID-9017895PMID: 208883922010Neuroscience Letters
Ying Lin, Akinori Kashio, Takashi Sakamoto, Keigo Suzukawa, Akinobu Kakigi, Tatsuya Yamasoba
It has been shown that molecular hydrogen acts as a therapeutic and preventive antioxidant by selectively reducing the hydroxyl radical, the most cytotoxic of the reactive oxygen species. In the present study, we tested the hypothesis that acoustic damage in guinea pigs can be attenuated by the consumption of molecular hydrogen. Guinea pigs received normal water or hydrogen-rich water for 14 days
Animal StudyHighlighted
MHID-7978470PMID: 198340322010Investigative Ophthalmology & Visual Science
Hideaki Oharazawa, Tsutomu Igarashi, Takashi Yokota, Hiroaki Fujii, Hisaharu Suzuki, Mitsuru Machide, et al.
PURPOSE. Retinal ischemia-reperfusion (I/R) injury by transient
elevation of intraocular pressure (IOP) is known to induce
neuronal damage through the generation of reactive oxygen
species. Study results have indicated that molecular hydrogen
(H2) is an efficient antioxidant gas that selectively reduces the
hydroxyl radical (OH) and suppresses oxidative stress-induced
injury in several organs. This
In VitroHighlighted
MHID-9110946PMID: 210427402010Oncology Reports
Ryoko Asada, KATSUHIRO KAGEYAMA, HIROSHI TANAKA, HISAKAZU MATSUI, MASATSUGU KIMURA, Yasukazu Saitoh, et al.
In order to erase reactive oxygen species (ROS) related with the proliferation of tumor cells by reducing activity of hydrogen, we developed functional water containing nano-bubbles (diameters: <900 nm for 71%/ population) hydrogen of 1.1-1.5 ppm (the theoretical maximum: 1.6 ppm) with a reducing ability (an oxidation- reduction potential -650 mV, normal water: +100-200 mV) using a microporous-fil
Animal StudyHighlighted
MHID-3863264PMID: 203516282010Shock
Keliang Xie, Yonghao Yu, Zishen Zhang, Wenbo Liu, Yuping Pei, Lize Xiong, et al.
Sepsis/multiple organ dysfunction syndrome is the leading cause of death in critically ill patients. Recently, it has been suggested that hydrogen gas (H2) exerts a therapeutic antioxidant activity by selectively reducing hydroxyl radical (&OH, the most cytotoxic reactive oxygen species). We have found that H2 inhalation significantly improved the survival rate and organ damage of septic mice with
Animal StudyHighlighted
MHID-7407969PMID: 195968252009Experimental Biology and Medicine
QIANG SUN, ZHIMIN KANG, JIANMEI CAI, WENWU LIU, YUN LIU, John H Zhang, et al.
Protective effect of hydrogen (H2) gas on cardiac ischemia-reperfusion (I/R) injury has been demonstrated previously. This study was designed to test the hypothesis that hydrogen-rich saline (saline saturated with molecular hydrogen), which is easy to use, induces cardioprotection against ischemia (30 min) and reperfusion (24 h) injury in rats. Adult male Sprague-Dawley rats underwent 30-min occlu
Animal StudyHighlighted
MHID-8852067PMID: 197896282009PLoS ONE
Kyota Fujita, Toshihiro Seike, Noriko Yutsudo, Mizuki Ohno, Hidetaka Yamada, Hiroo Yamaguchi, et al.
It has been shown that molecular hydrogen (H2) acts as a therapeutic antioxidant and suppresses brain injury by buffering the effects of oxidative stress. Chronic oxidative stress causes neurodegenerative diseases such as Parkinson’s disease (PD). Here, we show that drinking H2-containing water significantly reduced the loss of dopaminergic neurons in PD model mice using both acute and chronic adm
Animal StudyHighlighted
MHID-3088793PMID: 193565982009Neuroscience Letters
Yuan Fu, Mikako Ito, Yasunori Fujita, Masafumi Ito, Masatoshi Ichihara, Akio Masuda, et al.
Molecular hydrogen serves as an antioxidant that reduces hydroxyl radicals, but
not the other reactive oxygen and nitrogen species. In the past year, molecular hydrogen
has been reported to prevent or ameliorate eight diseases in rodents and one in human
associated with oxidative stress. In Parkinson’s disease, mitochondrial dysfunction and
the associated oxidative stress are major causes of dopam
Animal StudyIn VitroHighlighted
MHID-5929908PMID: 191486452009Cancer Chemotherapy and Pharmacology
Naomi Nakashima-Kamimura, Takashi Mori, Ikuroh Ohsawa, Sadamitsu Asoh, Shigeo Ohta
Purpose: Cisplatin is a widely used anti-cancer drug in the treatment of a wide range of tumors; however, its application is limited by nephrotoxicity, which is affected by oxidative stress. We have reported that molecular hydrogen (H(2)) acts as an efficient antioxidant (Ohsawa et al. in Nat Med 13:688-694, 2007). Here we show that hydrogen efficiently mitigates the side effects of cisplatin by r
Animal StudyHighlighted
MHID-8903197PMID: 176731692007Biochemical and Biophysical Research Communications
Kei-ichi Fukuda, Sadamitsu Asoh, Masahiro Ishikawa, Yasuhiro Yamamoto, Ikuroh Ohsawa, Shigeo Ohta
We have recently showed that molecular hydrogen has great potential for selectively reducing cytotoxic reactive oxygen species, such as hydroxyl radicals, and that inhalation of hydrogen gas decreases cerebral infarction volume by reducing oxidative stress [I. Ohsawa, M. Ishikawa, K. Takahashi, M. Watanabe, K. Nishimaki, K. Yamagata, K.-I. Katsura, Y. Katayama, S. Asoh, S. Ohta, Hydrogen acts as a
Animal StudyIn VitroHighlighted
MHID-7700658PMID: 174860892007Nature Medicine
Ikuroh Ohsawa, Masahiro Ishikawa, Kumiko Takahashi, Megumi Watanabe, Kiyomi Nishimaki, Kumi Yamagata, et al.
Acute oxidative stress induced by ischemia-reperfusion or inflammation causes serious damage to tissues, and persistent oxidative stress is accepted as one of the causes of many common diseases including cancer. We show here that hydrogen (H2) has potential as an antioxidant in preventive and therapeutic applications. We induced acute oxidative stress in cultured cells by three independent methods.
