In Vitro
MHID-7973359PMID: 284674972017PLOS ONE
Yayoi Murakami, Masafumi Ito, Ikuroh Ohsawa
Inhalation of molecular hydrogen (H2) gas ameliorates oxidative stress-induced acute injuries in the brain. Consumption of water nearly saturated with H2 also prevents chronic neurodegenerative diseases including Parkinson’s disease in animal and clinical studies. However, the molecular mechanisms underlying the remarkable effect of a small amount of H2 remain unclear. Here, we investigated the ef
HypothesisHighlighted
MHID-0066983PMID: 284354682017Theranostics
Sergej M Ostojic
More than 400 original articles have been published from 2007 onwards evaluating therapeutic potential of molecular hydrogen (H2), the youngest member of medical gases family with selective anti-oxidative properties. However, recent studies suggest that H2 may tackle other mitochondrial processes besides oxidative stress, including metabolic pathways that drive cellular energy.
Animal StudyHighlighted
MHID-3260346PMID: 288484322017Frontiers in Pharmacology
Jing Chen, Han Zhang, Jiachang Hu, Yulu Gu, Ziyan Shen, Linghan Xu, et al.
Purpose: Acute kidney injury (AKI) is a prominent risk factor for the development of chronic kidney disease (CKD). To date, the related mechanism and effective therapy have not been rigorously explored. The present study aims to investigate the reno- protection of hydrogen-rich saline (HRS) against ischemia/reperfusion (IR)-induced AKI.
Methods: Adult male C57 mice were randomly allocated into th
Literature Review
MHID-6430381PMID: 276439332016Physiological Research
J. Slezák, B. Kura, K. Frimmel, M. Zálešák, T. Ravingerová, C. Viczenczová, et al.
Excessive production of oxygen free radicals has been regarded as a causative common denominator of many pathological processes in the animal kingdom. Hydroxyl and nitrosyl radicals represent the major cause of the destruction of biomolecules either by a direct reaction or by triggering a chain reaction of free radicals. Scavenging of free radicals may act preventively or therapeutically. A number
In VitroChemical/Physicochemical StudyHighlighted
MHID-6183029PMID: 267392572016Scientific Reports
Katsuya Iuchi, Akemi Imoto, Naomi Kamimura, Kiyomi Nishimaki, Harumi Ichimiya, Takashi Yokota, et al.
We previously showed that H2 acts as a novel antioxidant to protect cells against oxidative stress. Subsequently, numerous studies have indicated the potential applications of H2 in therapeutic and preventive medicine. Moreover, H2 regulates various signal transduction pathways and the expression of many genes. However, the primary targets of H2 in the signal transduction pathways are unknown. Her
Animal StudyHighlighted
MHID-5889693PMID: 257075802015Molecular and Cellular Biochemistry
Sayaka Sobue, Kazuaki Yamai, Mikako Ito, Kinji Ohno, Masafumi Ito, Takashi Iwamoto, et al.
Molecular hydrogen (H2) is an agent with po- tential applications in oxidative stress-related and/or in- flammatory disorders. H2 is usually administered by inhaling H2-containing air (HCA) or by oral intake of H2- rich water (HRW). Despite mounting evidence, the mole- cular mechanism underlying the therapeutic effects and the optimal method of H2 administration remain unclear. Here, we investigate
Plant Study
MHID-7838829PMID: 239510752013PLoS ONE
Jiqing Zeng, Mingyong Zhang, Xuejun Sun
Molecular hydrogen (H2) metabolism in bacteria and algae has been well studied from an industrial perspective because H2
is viewed as a potential future energy source. A number of clinical trials have recently reported that H2 is a therapeutic
antioxidant and signaling molecule. Although H2 metabolism in higher plants was reported in some early studies, its
biological effects remain unclear. In th
In Vitro
MHID-3711683PMID: 238265192013International Journal of Ophthalmology
GD Liu, H Zhang, L Wang, Q Han, SF Zhou, P Liu
AIM: To explore the potential mechanism of molecular hydrogen in the regulation of miRNA expression and signal-modulating activities.
METHODS: Retinal microglia cells were activated by Lipopolysaccharides (LPS) and then treated with hydrogen -saturated medium or normal medium without hydrogen. qRT-PCR was used to detect the expression difference in miR-9, miR-21 and miR-199 between these two grou
In VitroHighlighted
MHID-9934004PMID: 234482062013Medical Gas Research
Akio Iio, Mikako Ito, Tomohiro Itoh, Riyako Terazawa, Yasunori Fujita, Yoshinori Nozawa, et al.
Background: There is accumulating evidence that obesity is closely associated with an impaired free fatty acid metabolism as well as with insulin resistance and inflammation. Excessive fatty acid uptake mediated by fatty acid translocase CD36 plays an important role in hepatic steatosis. Molecular hydrogen has been shown to attenuate oxidative stress and improve lipid, glucose and energy metabolis
Animal StudyHighlighted
MHID-09896642012Biochemical and Biophysical Research Communications
Yugo Tanaka, Norihisa Shigemura, Tomohiro Kawamura, Kentaro Noda, Kumiko Isse, Donna Beer Stolz, et al.
Background—We previously demonstrated that donor treatment with inhaled hydrogen protects lung grafts from cold ischemia/reperfusion (I/R) injury during lung transplantation. To elucidate the mechanisms underlying hydrogen’s protective effects, we conducted a gene array analysis to identify changes in gene expression associated with hydrogen treatment.
Methods—Donor rats were exposed to mechanica
Animal StudyIn Vitro
MHID-5661317PMID: 223730562011BMC Proceedings
Sanetaka Shirahata, Takeki Hamasaki, Keisuke Haramaki, Takuro Nakamura, Masumi Abe, Hanxu Yan, et al.
Electrochemically reduced water (ERW) contains a lot of hydrogen molecule (H2) and scavenges reactive oxygen species (ROS) to protect DNA from oxidative damage [1]. ERW also contains small amounts of Pt nanoparticles (NPs) and elongates the lifespan of C. elegans [2]. Pt NPs are newly recognized multi-functional ROS scavengers [3]. ERW exhibits anti-diabetes effects in vitro and in vivo [4-6][7].
