Animal StudyHighlighted
MHID-9053506PMID: 355085712022Scientific Reports
Fei Xie, Xue Jiang, Yang Yi, Zi‑Jia Liu, Chen Ma, Jin He, et al.
The potential for preventive and therapeutic applications of H2 have now been confirmed in various disease. However, the effects of H2 on health status have not been fully elucidated. Our previous study reported changes in the body weight and 13 serum biochemical parameters during the six-month hydrogen intervention. To obtain a more comprehensive understanding of the effects of long-term hydrogen
Clinical TrialObservational StudyHighlighted
MHID-99610682021Journal of Education, Health and Sport
Yurii Rohovyi, Volf Tsitrin, Yula Bilooka, Ludmila Arkchipova, Vyacheslav Bilookiy
Aim. To find out a pathophysiological protective role of influence of molecular hydrogen on a functional condition of a proximal tubule of kidneys at an irritable bowel syndrome.
Materials and methods. 60 patients with irritable bowel syndrome were examined. Men - 18, women - 42 aged from 28 to 62 years. Of which: with irritable bowel syndrome with constipation were - 28 patients, irritable bowel
Animal StudyIn VitroHighlighted
MHID-2423362PMID: 334391022021American Journal of Physiology - Gastrointestinal and Liver Physiology
Shao-Wei Li, Terumi Takahara, Weitao Que, Masayuki Fujino, Wen-Zhi Guo, Shin-ichi Hirano, et al.
Nonalcoholic steatohepatitis (NASH) could progress to hepatic fibrosis in the absence of effective control. The purpose of our experiment was to investigate the protective effect of drinking water with a high concentration of hydrogen, namely, hydrogen-rich water (HRW), on mice with nonalcoholic fatty liver disease to elucidate the mechanism underlying the therapeutic action of molecular hydrogen.
Systematic ReviewHighlighted
MHID-30922442021Journal of Syiah Kuala Dentistry Society
Albert Manggading Hutapea, Lina Hadi
Diabetes Mellitus (DM) is a metabolic disorder characterized by high blood glucose levels associated with periodontal disease and increased levels of inflammatory biomarkers such as interleukin. Therapeutic effects of molecular hydrogen for a wide range of disease models and human diseases have been investigated. This review aims to systematically analyze and review animal and human studies invest
HypothesisOpinion Piece
MHID-9436520PMID: 329827932020Frontiers in Physiology
Sergej M Ostojic
Barton et al. (2018) have recently evaluated the differences in fecal microbiota between professional rugby players and healthy age-matched sedentary controls. The authors reported a rather preferential intestinal microbiome profile in physically active individuals, characterized by the greater microbial diversity and functional/metabolic activity, as evaluated by whole metagenome shotgun sequencing
HypothesisHighlighted
MHID-3994699PMID: 324455282020Alimentary Pharmacology & Therapeutics
Sergej M Ostojic
EDITORS, I have read with great interest the systematic review with meta- analysis written by Ianiro and co-workers,1 in which the authors have evaluated the efficacy of faecal microbiota transplantation (FMT, or bacteriotherapy) for the treatment of irritable bowel syndrome (IBS). Although only a handful of studies were eligible to be included in this meticulous analysis, the authors implied that
Observational StudyHighlighted
MHID-3602984PMID: 312492542019Medical Gas Research
Ryoko Asada, Yasukazu Saitoh, Nobuhiko Miwa
Hydrogen-dissolved water has been shown to improve diverse oxidation stress-related diseases, which drove us to examine effects of hydrogen-rich water on oxidation stress-related skin troubles and lipid-metabolism markers. The purpose of this study is whether the dissolved hydrogen in hydrogen-rich water was kept even after boiling, and whether hydrogen-bath utilization improves cosmetic effects s
Clinical TrialHighlighted
MHID-9688108PMID: 309827482019Clinics and Research in Hepatology and Gastroenterology
Darinka Korovljev, Valdemar Stajer, Jelena Ostojic, Tyler W. LeBaron, Sergej M Ostojic
Background and aims: While non-alcoholic fatty liver disease (NAFLD) is rapidly becoming the most common liver disease worldwide, its treatment remains elusive. Since metabolic impairment plays a major role in NAFLD pathogenesis, any pharmaceuticals, such as molecular hydrogen (H2), that advance lipid and glucose metabolism could be appropriate to tackle this complex condition. The aim of this stu
Clinical TrialObservational StudyHighlighted
MHID-0370162PMID: 305427402019Oncology Reports
Junji Akagi, Hideo Baba
Exhausted cluster of differentiation (CD)8+ T cells lose immunological activity due to mitochondrial dysfunction caused by peroxisome proliferator‑activated receptor γ coactivator 1α (PGC‑1α) inactivation, resulting in a poor prognosis in patients with cancer. As hydrogen gas was recently reported to activate PGC‑1α, the present study investigated whether it restores exhausted CD8+ T cells to impr
Literature Review
MHID-8766047PMID: 311002032019Canadian Journal of Physiology and Pharmacology
Mami Noda, Yuya Uemura, Yusuke Yoshii, Taichi Horita, Shota Takemi, Ichiro Sakata, et al.
Molecular hydrogen (H2) showed protection against various kinds of oxidative stress-
related diseases. First it was reported that the mechanism of therapeutic effects of H2 was
anti-oxidative effect due to inhibition of most cytotoxic reactive oxygen species (ROS),
hydroxy radical (•OH). However, after chronic administration of H2 in drinking water,
oxidative stress-induced nerve injury is signifi
Animal Study
MHID-4869388PMID: 316002562019PLoS ONE
Laura Bordoni, Rosita Gabbianelli, Donatella Fedeli, Dennis Fiorini, Ina Bergheim, Cheng Jun Jin, et al.
There is growing awareness within the scientific community of the strong connection between the inflammation in the intestine and the pathogenesis of Parkinson’s disease (PD). In previous studies we developed a PD animal model exposing pup rats to permethrin (PERM) pesticide. Here, we intended to explore whether in our animal model there were changes in gut permeability, fecal microbiota and hepat
Animal StudyIn VitroHighlighted
MHID-6163351PMID: 305683872018World Journal of Gastroenterology
Karen Jackson, Noa Dressler, Rotem S Ben-Shushan, Ari Meerson, Tyler W. LeBaron, Snait Tamir
AIM To identify the effect of hydrogen-rich water (HRW) and electrolyzed-alkaline water (EAW) on high-fat-induced non-alcoholic fatty acid disease in mice.
METHODS Mice were divided into four groups: (1) Regular diet (RD)/regular water (RW); (2) high-fat diet (HFD)/RW; (3) RD/EAW; and (4) HFD/EAW. Weight and body composition were measured. After twelve weeks, animals were sacrificed, and livers w
In VitroIn SilicoHighlighted
MHID-67149392018PLoS ONE
Anzu Suzuki, Mikako Ito, Tomonori Hamaguchi, Hiroshi Mori, Yuka Takeda, Ryuko Baba, et al.
Oral administration of hydrogen water ameliorates Parkinson’s disease (PD) in rats, mice, and humans. We previously reported that the number of putative hydrogen-producing bacte- ria in intestinal microbiota is low in PD compared to controls. We also reported that the amount of hydrogen produced by ingestion of lactulose is low in PD patients. The decreased hydrogen production by intestinal microb
Animal StudyIn SilicoHighlighted
MHID-9900832PMID: 294242532018
Hiroshi Nishiwaki, Mikako Ito, Shuto Negishi, Sayaka Sobue, Masatoshi Ichihara, Kinji Ohno
Background: Molecular hydrogen exerts its effect on multiple pathologies, including oxidative stress, inflammation, and apoptosis. However, its molecular mechanisms have not been fully elucidated. In order to explore the effects of molecular hydrogen, we meta-analyzed gene expression profiles modulated by molecular hydrogen.
Methods: We performed microarray analysis of the mouse liver with or wit
Literature Review
MHID-7641248PMID: 296834802018Federation of European Biochemical Societies (FEBS) Letters
Phillip B. Hylemon, Spencer C. Harris, Jason M. Ridlon
The human gut microbiome refers to a highly diverse microbial ecosystem, which has a symbiotic relationship with the host. Molecular hydrogen (H2) and carbon dioxide (CO2) are generated by fermentative metabolism in anaerobic ecosystems. H2 generation and oxidation coupled to CO2 reduction to methane or acetate help maintain the structure of the gut microbiome. Bile acids are synthesized by hepato
Literature Review
MHID-31863052018Asia-Pacific Journal of Blood Types and Genes
Jinqi Li, Yan Zang, Haihui Gu, Baohua Qian
Hydrogen (H2) is a colorless, odorless gas that can act as a reducing agent under certain circumstances. Previously considered physiologically an inert and nonfunctional molecule in mammalian cells, H2 largely went ignored until Nature Medicine revealed the antioxidant and cytoprotective effects of hydrogen gas in a focal stroke model. Reactive oxygen species (ROS) is generated inside the body thr
Animal StudyHighlighted
MHID-6423123PMID: 298670312018Toxins
Weijiang Zheng, Xu Ji, Qing Zhang, Wenchao Du, Quanwei Wei, Wen Yao
The objective of the current experiment was to evaluate whether hydrogen-rich water (HRW) or lactulose (LAC) could protect against the adverse effects of Fusarium mycotoxins-contaminated diet on the growth performance and antioxidant status in weaning piglets. A total of 24 individually housed female piglets were randomly assigned to receive four treatments for 25 days (six pigs/treatment): uncont
Clinical TrialHighlighted
MHID-6786572PMID: 307136692018Medical Gas Research
Yoshinori Tanaka, Yasuhiro Saihara, Kyoko Izumotani, Hajime Nakamura
In Japan, alkaline electrolyzed water (AEW) apparatus have been approved as a medical device. And for the patients with gastrointestinal symptoms, drinking AEW has been found to be effective in relieving gastrointestinal symptoms. But some users of AEW apparatus do not have abdominal indefinite complaint. Little attention has been given to the benefit for the users which have no abdominal indefini
HypothesisHighlighted
MHID-0066983PMID: 284354682017Theranostics
Sergej M Ostojic
More than 400 original articles have been published from 2007 onwards evaluating therapeutic potential of molecular hydrogen (H2), the youngest member of medical gases family with selective anti-oxidative properties. However, recent studies suggest that H2 may tackle other mitochondrial processes besides oxidative stress, including metabolic pathways that drive cellular energy.
Animal StudyHighlighted
MHID-6252416PMID: 280987682017Nutrients
Toshiki Yoneda, Takaaki Tomofuji, Muneyoshi Kunitomo, Daisuke Ekuni, Koichiro Irie, Tetsuji Azuma, et al.
Obesity induces gingival oxidative stress, which is involved in the progression of alveolar bone resorption. The antioxidant effect of hydrogen-rich water may attenuate gingival oxidative stress and prevent alveolar bone resorption in cases of obesity. We examined whether hydrogen-rich water could suppress gingival oxidative stress and alveolar bone resorption in obese rats fed a high-fat diet. Ma
