Animal StudyHighlighted
MHID-0865356PMID: 213757532015The Journal of Thoracic and Cardiovascular Surgery
Yasuaki Kishimoto, MD, Taichi Kato, MD, PhD, Mikako Ito, PhD, Yoshiteru Azuma, MD, Yoshie Fukasawa, MD, Kinji Ohno, MD, PhD, et al.
Objective: The pathogenesis of pulmonary arterial hypertension (PAH) involves reactive oxygen species and inflammation. Beneficial effects of molecular hydrogen, which exerts both anti-inflammatory and antioxidative effects, have been reported for various pathologic conditions. We therefore hypothesized that molecular hydrogen would improve monocrotaline (MCT)-induced PAH in rats.
Methods: Nineteen
Literature ReviewHighlighted
MHID-7479916PMID: 264839532015Medical Gas Research
Masatoshi Ichihara, Sayaka Sobue, Mikako Ito, Masafumi Ito, Masaaki Hirayama, Kinji Ohno
Therapeutic effects of molecular hydrogen for a wide range of disease models and human diseases have been investigated since 2007. A total of 321 original articles have been published from 2007 to June 2015. Most studies have been conducted in Japan, China, and the USA. About three-quarters of the articles show the effects in mice and rats. The number of clinical trials is increasing every year. I
Animal StudyHighlighted
MHID-4748086PMID: 260479402015Journal of Translational Medicine
Song‑Xue Guo, Quan Fang, Chuan‑Gang You, Yun‑Yun Jin, Xin‑Gang Wang, Xin‑Lei Hu, et al.
Background: Early acute kidney injury (AKI) in severely burned patients predicts a high mortality that is multi-factorial. Hydrogen has been reported to alleviate organ injury via selective quenching of reactive oxygen species. This study investigated the potential protective effects of hydrogen against severe burn-induced early AKI in rats.
Methods: Severe burn were induced via immersing the sha
Animal StudyHighlighted
MHID-1117942PMID: 251770312014Biological & Pharmaceutical Bulletin
Yang-Suk Yoon, Ma. Easter Joy Villarosa Sajo, Rosa Mistica Coles Ignacio, Soo-Ki Kim, Cheol-Su Kim, Kyu-Jae Lee
Atopic dermatitis (AD) is a chronically relapsing, pruritic, eczematous skin disorder accompanying al- lergic inflammation. AD is triggered by oxidative stress and immune imbalance. In the present study, we in- vestigated the effect of drinking hydrogen water (HW) on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis in NC/Nga mice and found that HW ameliorated DNCB-induced AD-like clinical
Animal StudyIn VitroHighlighted
MHID-0826156PMID: 246851142014CNS Neuroscience & Therapeutics
Fang-Ting Liu, Sheng-Ming Xu, Zheng-Hua Xiang, Xiang-Nan Li, Jian Li, Hong-Bin Yuan, et al.
Aims: Spinal cord injury (SCI) can induce excessive astrocyte activation. Hydrogen has been deemed as a novel antioxidant. We investigated whether molecular hydrogen could act as an antiastrogliosis agent during SCI and oxidative injury in experimental rats and cultured astrocytes. Methods: Hydrogen-rich saline (HS, 8 mL/kg, i.p.) was injected every 12 h after SCI in rats. The expression of STAT3,
Animal StudyHighlighted
MHID-5761446PMID: 246182602014Journal of Cellular and Molecular Medicine
Sanhu Zhao, Yanyong Yang, Wen Liu, Zhiqiang Xuan, Shouming Wu, Shunfei Yu, et al.
Recent studies showed that hydrogen can be used as an effective radioprotective agent through scavenging free radicals. This study was under-
taken to evaluate the radioprotective effects of hydrogen on immune system in mice. H2 was dissolved in physiological saline using an apparatus
produced by our department. Spleen index and histological analysis were used to evaluate the splenic structural da
Clinical TrialHighlighted
MHID-29235562014Sports medicine / News in Molecular Hydrogen Biomedicine
Sergej M Ostojic, Boris Vukomanovic, Julio Calleja-Gonzalez, Jay R Hoffman
Background: Because hydrogen therapy has been found beneficial for the treatment of inflammation, ischemia-reperfusion injury, and oxidative stress in humans, it seems useful to evaluate the effects of exogenously administered hydrogen as an element in the immediate management of sports-related soft tissue injuries. The main aim of this pilot study was to examine the effects of 2-week administrati
In Vitro
MHID-3711683PMID: 238265192013International Journal of Ophthalmology
GD Liu, H Zhang, L Wang, Q Han, SF Zhou, P Liu
AIM: To explore the potential mechanism of molecular hydrogen in the regulation of miRNA expression and signal-modulating activities.
METHODS: Retinal microglia cells were activated by Lipopolysaccharides (LPS) and then treated with hydrogen -saturated medium or normal medium without hydrogen. qRT-PCR was used to detect the expression difference in miR-9, miR-21 and miR-199 between these two grou
Animal StudyHighlighted
MHID-1417416PMID: 234757672013American Journal of Physiology - Lung Cellular and Molecular Physiology
Tomohiro Kawamura, Nobunao Wakabayashi, Norihisa Shigemura, Chien-Sheng Huang, Kosuke Masutani, Yugo Tanaka, et al.
Hyperoxic lung injury is a major concern in critically ill patients who receive high concentrations of oxygen to treat lung diseases. Successful abrogation of hyperoxic lung injury would have a huge impact on respiratory and critical care medicine. Hydrogen can be administered as a therapeutic medical gas. We recently demonstrated that inhaled hydrogen reduced transplant-induced lung injury and in
In VitroHighlighted
MHID-1519950PMID: 241487942013International Journal of Surgery
Hong-Guang Chen, Ke-Liang Xie, Huan-Zhi Han, Wei-Na Wang, Da-Quan Liu, Guo-Lin Wang, et al.
Background: Molecular hydrogen (H2) as a new medical gas has an anti-inflammatory effect. In the present study, we investigated whether heme oxygenase-1 (HO-1) contributes to the anti-inflammatory effect of H2 in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages.
Methods: RAW 264.7 macrophages were stimulated by LPS (1 mg/mL) with presence or absence of different concentrations of H2. Cell
Animal StudyHighlighted
MHID-5043020PMID: 236615162013European Review for Medical and Pharmacological Sciences
M. Xiao, T. Zhu, T. Wang, F.-Q. Wen
Recent studies suggest that hydrogen has great therapeutic and prophylactic potential against organ injury caused by oxidative stress and inflammation. Here we investigated the effect of hydrogen-rich saline on airway inflammation and remodeling in a murine model of asthma.
MATERIALS AND METHODS: Asthma was induced by ovalbumin (OVA) sensitization and challenge. Then mice were treated with normal
Animal StudyIn VitroHighlighted
MHID-7737580PMID: 231402242012Transplant International
Kentaro Noda, Yugo Tanaka, Norihisa Shigemura, Tomohiro Kawamura, Yinna Wang, Kosuke Masutani, et al.
Recent evidence suggests that molecular hydrogen has therapeutic value for dis-
ease states that involve inflammation. We hypothesized that drinking hydro-
gen-rich water (HW) daily would protect cardiac and aortic allograft recipients
from inflammation-associated deterioration. Heterotopic heart transplantation
with short-course tacrolimus immunosuppression and orthotopic aortic trans-
plantation w
Animal StudyHighlighted
MHID-09896642012Biochemical and Biophysical Research Communications
Yugo Tanaka, Norihisa Shigemura, Tomohiro Kawamura, Kentaro Noda, Kumiko Isse, Donna Beer Stolz, et al.
Background—We previously demonstrated that donor treatment with inhaled hydrogen protects lung grafts from cold ischemia/reperfusion (I/R) injury during lung transplantation. To elucidate the mechanisms underlying hydrogen’s protective effects, we conducted a gene array analysis to identify changes in gene expression associated with hydrogen treatment.
Methods—Donor rats were exposed to mechanica
Literature Review
MHID-5039793PMID: 227201172012Oxidative Medicine and Cellular Longevity
Kinji Ohno, Mikako Ito, Masatoshi Ichihara, Masafumi Ito
Effects of molecular hydrogen on various diseases have been documented for 63 disease models and human diseases in the past four and a half years. Most studies have been performed on rodents including two models of Parkinson’s disease and three models of Alzheimer’s disease. Prominent effects are observed especially in oxidative stress-mediated diseases including neonatal cerebral hypoxia; Parkinson
Animal Study
MHID-20640112012Shock
Keliang Xie, Yonghao Yu, Yi Huang, Lina Zheng, Jipeng Li, Hongguang Chen, et al.
Acute lung injury (ALI) is still a leading cause of morbidity and mortality in critically ill patients. Recently, our and other studies have found that hydrogen gas (H2) treatment can ameliorate the lung injury induced by sepsis, ventilator, hyperoxia, and ischemia-reperfusion. However, the molecular mechanisms by which H2 ameliorates lung injury remain unclear. In the current study, we investigat
Human StudyLiterature ReviewAnimal StudyIn VitroHighlighted
MHID-1756030PMID: 221460822011Medical Gas Research
Shigeo Ohta, Atsunori Nakao, Kinji Ohno
This report summarizes a brief description/history of the Hydrogen Research Meetings as well as key presentations/oral abstracts delivered in the most recent symposium. Additionally, we introduced 38 diseases and physiological states for which hydrogen exhibits beneficial effects.
Clinical TrialHighlighted
MHID-2481572PMID: 221466742011Medical Gas Research
Mikako Ito, Tohru Ibi, Ko Sahashi, Masashi Ichihara, Masafumi Ito, Kinji Ohno
Background: Molecular hydrogen has prominent effects on more than 30 animal models especially of oxidative stress-mediated diseases and inflammatory diseases. In addition, hydrogen effects on humans have been reported in diabetes mellitus type 2, hemodialysis, metabolic syndrome, radiotherapy for liver cancer, and brain stem infarction. Hydrogen effects are ascribed to specific radical-scavenging
Animal StudyIn VitroHighlighted
MHID-1458727PMID: 217232542011Biochemical and Biophysical Research Communications
Tomohiro Itoh, Nanako Hamada, Riyako Terazawa, Mikako Ito, Kinji Ohno, Masatoshi Ichihara, et al.
Molecular hydrogen has been reported to be effective for a variety of disorders and its effects have been ascribed to the reduction of oxidative stress. However, we have recently demonstrated that hydrogen inhibits type I allergy through modulating intracellular signal transduction. In the present study, we examined the hydrogen effects on lipopolysaccharide/interferon c LPS/IFNc-induced nitric ox
Animal StudyHighlighted
MHID-3863264PMID: 203516282010Shock
Keliang Xie, Yonghao Yu, Zishen Zhang, Wenbo Liu, Yuping Pei, Lize Xiong, et al.
Sepsis/multiple organ dysfunction syndrome is the leading cause of death in critically ill patients. Recently, it has been suggested that hydrogen gas (H2) exerts a therapeutic antioxidant activity by selectively reducing hydroxyl radical (&OH, the most cytotoxic reactive oxygen species). We have found that H2 inhalation significantly improved the survival rate and organ damage of septic mice with
Animal StudyHighlighted
MHID-1488636PMID: 192522952009Biological & Pharmaceutical Bulletin
Kyu Jae LEE, Dan JIN, Byung Soo CHANG, Yung Chien TENG, Dong Heui KIM
Electrolyzed reduced water (ERW) is widely used for drinking by people in Asia. The purpose of this study was to examine the immunological effect of ERW on the immunity of animals by supplying ERW to C57BL/6 mice infected with Echinostoma hortense metacercariae. In the non-infected groups, interleukin (IL)-4 (p0.001), IL-5, IL-10, IL-1b, tumor necrosis factor (TNF)-a and immunoglobulin (Ig) A exp
