Hypothesis
MHID-2190797PMID: 409385202025Intensive Care Medicine Experimental
Lakhmir S. Chawla
Molecular hydrogen gas (HG), administered through inhalation or as hydrogen-rich fluids (HRF), has demonstrated antioxidant, anti-inflammatory, antiapoptotic, cytoprotective, and beneficial mitochondrial effects in critical illness. Preclinical studies and human clinical studies consistently endorse hydrogen gas as safe, with mechanisms of action linked to vital molecular pathways, such as reducti
Literature Review
MHID-0000311PMID: 390631262024International Journal of Molecular Sciences
Branislav Kura, Jan Slezak
Ischemia/reperfusion injury (IRI) represents a significant contributor to morbidity and mortality associated with various clinical conditions, including acute coronary syndrome, stroke, and organ transplantation. During ischemia, a profound hypoxic insult develops, resulting in cellular dysfunction and tissue damage. Paradoxically, reperfusion can exacerbate this injury through the generation of r
Literature ReviewHighlighted
MHID-0274938PMID: 385398462024Antioxidants
Di Hu, Shigeru Kabayama, Yasuyoshi Watanabe, Yilong Cui
Molecular hydrogen, the smallest and lightest molecule, serves as an intense reducing agent. Its distinct characteristics, including minimal size and neutral charge, enhance bioavailability and facilitate significant biological effects. Previously considered physiologically inert, hydrogen has gained recognition as a powerful therapeutic agent, known for its antioxidative and anti-inflammatory pro
Chemical/Physicochemical StudyHypothesisHighlighted
MHID-10655712023Aging Pathobiology and Therapeutics
Shigeo Ohta
Oxidative stress is one of the major causes of most age-dependent neurodegenerative disorders. Neurons accumulate oxidative damage over time due to post-mitotic cells. Thus, modulation of oxidative stress is essential to overcome these disorders. Molecular hydrogen (H2) has great potential for treating various diseases and improving quality of life by exerting multiple functions including anti-oxi
Literature ReviewHighlighted
MHID-6539221PMID: 372378542023Antioxidants
Md. Habibur Rahman, Eun-Sook Jeong, Hae Sun You, Cheol-Su Kim, Kyu-Jae Lee
Age-related diseases represent the largest threat to public health. Aging is a degenerative, systemic, multifactorial and progressive process, coupled with progressive loss of function and eventually leading to high mortality rates. Excessive levels of both pro- and anti-oxidant species qualify as oxidative stress (OS) and result in damage to molecules and cells. OS plays a crucial role in the dev
Animal StudyHighlighted
MHID-0513892PMID: 351161142022World Journal of Gastrointestinal Oncology
Fereshteh Asgharzadeh, Alex Tarnava, Asma Mostafapour, Majid Khazaei, Tyler W. LeBaron
Background: Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in the world. Tumor removal remains the preferred frontline treatment; however, effective non-surgical interventions remain a high priority. 5-fluorouracil (5-FU) is a widely used chemotherapy agent, and molecular hydrogen (H2) has been re- cognized for its antioxidant and anti-inflammatory effects, with resear
Chemical/Physicochemical StudyHighlighted
MHID-3839513PMID: 361933472022Journal of Food Science and Technology
Duried Alwazeer, Nur Özkan
Strawberries are known for their high perishability and short shelf life. The effects of incorporating hydrogen gas into sealed packaging on the quality and shelf life of strawberries were evaluated. Fruits were packaged under reducing atmosphere [RAP1 (5% CO2, 4% H2, 91% N2) and RAP2 (10% CO2, 4% H2, 86% N2)], modified atmosphere [MAP1 (5% CO2, 95% N2) and MAP2 (10% CO2, 90% N2)], and control, fol
Literature Review
MHID-9272690PMID: 330783742021Neuroscience Bulletin
Wei Chen, Han-Ting Zhang, Shu-Cun Qin
Molecular hydrogen (H2) is a physiologically inert gas. However, during the last 10 years, increasing evidence has revealed its biological functions under pathological conditions. More specifically, H2 has protec- tive effects against a variety of diseases, particularly nervous system disorders, which include ischemia/reperfu- sion injury, traumatic injury, subarachnoid hemorrhage, neuropathic pain
Literature Review
MHID-0972119PMID: 342812642021International Journal of Molecular Sciences
Haru Yamamoto, Yusuke Ichikawa, Shin-ichi Hirano, Bunpei Sato, Yoshiyasu Takefuji, Fumitake Satoh
Mibyou, or pre-symptomatic diseases, refers to state of health in which a disease is slowly developing within the body yet the symptoms are not apparent. Common examples of mibyou in modern medicine include inflammatory diseases that are caused by chronic inflammation. It is known that chronic inflammation is triggered by the uncontrolled release of proinflammatory cytokines by neutrophils and macroph
Clinical Trial
MHID-9025289PMID: 326992872020Scientific Reports
Minju Sim, Chong‑Su Kim, Woo‑Jeong Shon, Young‑Kwan Lee, Eun Young Choi, Dong‑Mi Shin
The evidence for the beneficial effects of drinking hydrogen-water (HW) is rare. We aimed to investigate the effects of HW consumption on oxidative stress and immune functions in healthy adults using systemic approaches of biochemical, cellular, and molecular nutrition. In a randomized, double-blind, placebo-controlled study, healthy adults (20–59 y) consumed either 1.5 L/d of HW (n = 20) or plain
Literature Review
MHID-1929560PMID: 317383892019Acta Biochimica et Biophysica Sinica
Geru Tao, Guohua Song, Shucun Qin
Ever since molecular hydrogen was first reported as a hydroxyl radical scavenger in 2007, the beneficial effect of hydrogen was documented in more than 170 disease models and human diseases including ischemia/reperfusion injury, metabolic syndrome, inflammation, and cancer. All these pathological damages are concomitant with overproduction of reactive oxygen species (ROS) where molecular hydrogen has
Literature Review
MHID-1011283PMID: 312232852019International Journal of Biological Sciences
Peng Qiu, Yang Liu, Jin Zhang
Sepsis is a syndrome comprised of a series of life-threatening organ dysfunctions caused by a maladjusted body response to infection with no effective treatment. Molecular hydrogen is a new type of antioxidant with strong free radical scavenging ability, which has been demonstrated to be effective for treating various diseases, such as infection, trauma, poisoning, organ ischemia-reperfusion, meta
Literature Review
MHID-5774686PMID: 301278612018Oncology Letters
Ye Yang, Yaping Zhu, Xiaowei Xi
Hydrogen (H2) has advantages that lead it to be
used as a novel antioxidant in preventive and therapeutic
applications. H2 can permeate into biomembranes, cytosol,
mitochondria and nuclei, and can be dissolved in water or
saline to produce H2 water or H2‑rich saline. H2 selectively
reduces oxidants of the detrimental reactive oxygen species
(ROS), including hydroxyl radicals (·OH) and peroxynitrit
Chemical/Physicochemical Study
MHID-6682168PMID: 250864382014Free Radical Biology and Medicine
Jelle Penders, Reinhard Kissner, Willem H. Koppenol
H2 has been suggested to act as an antioxidant when administered just before the reperfusion phase of induced oxidative stress. These effects have been reported, for example, for the heart, brain, and liver. It is hypothesized that this beneficial effect may be due to selective scavenging of HO⋅ and ONOOH by H2. The reaction of H2 with HO⋅ has been studied by pulse radiolysis in the past and is too
Literature Review
MHID-8352354PMID: 216215882012Biochimica et Biophysica Acta
Shigeo Ohta
Background: Mitochondria are the major source of oxidative stress. Acute oxidative stress causes serious damage to tissues, and persistent oxidative stress is one of the causes of many common diseases, cancer and the aging process; however, there has been little success in developing an effective antioxidant with no side effect. We have reported that molecular hydrogen has potential as an effectiv
Hypothesis
MHID-5798200PMID: 212751142010West Indian Medical Journal
Liren Qian, Bailong Li, Jianming Cai, Fu Gao
Most ionizing radiation-induced damage is caused by radical oxygen species (ROS).
Some
radioprotectors, such as amifostine, exert radioprotective effects by scavenging radical oxygen species.
Recent studies show that hydrogen (H2) has antioxidant activities that protect the brain and intestine
against ischaemia-reperfusion injury and stroke by selectively reducing hydroxyl and peroxynitrite
radica
Animal StudyHighlighted
MHID-8903197PMID: 176731692007Biochemical and Biophysical Research Communications
Kei-ichi Fukuda, Sadamitsu Asoh, Masahiro Ishikawa, Yasuhiro Yamamoto, Ikuroh Ohsawa, Shigeo Ohta
We have recently showed that molecular hydrogen has great potential for selectively reducing cytotoxic reactive oxygen species, such as hydroxyl radicals, and that inhalation of hydrogen gas decreases cerebral infarction volume by reducing oxidative stress [I. Ohsawa, M. Ishikawa, K. Takahashi, M. Watanabe, K. Nishimaki, K. Yamagata, K.-I. Katsura, Y. Katayama, S. Asoh, S. Ohta, Hydrogen acts as a
