The Hypothesis of an Effective Safe and Novel Radioprotective Agent: Hydrogen-rich Solution

Abstract

Most ionizing radiation-induced damage is caused by radical oxygen species (ROS). Some radioprotectors, such as amifostine, exert radioprotective effects by scavenging radical oxygen species. Recent studies show that hydrogen (H2) has antioxidant activities that protect the brain and intestine against ischaemia-reperfusion injury and stroke by selectively reducing hydroxyl and peroxynitrite radicals. However, it is seldom regarded as a radioprotective agent. In like manner, we hypothesize that hydrogen may be an effective, specific and novel radioprotective agent. But H2 is explosive, while hydrogen-rich solution (solution such as physiological saline saturated with molecular hydrogen) is safer.

Study details

Article type

Hypothesis

Disease / injury model

Radiation-induced injury (radioprotection)

Outcome

Positive

Findings

The article hypothesizes that hydrogen-rich solution may serve as a promising, effective, and safe radioprotective agent by selectively reducing hydroxyl and peroxynitrite radicals, which are responsible for most ionizing radiation-induced cellular damage. The authors argue that hydrogen-rich solution is safer and more convenient than direct hydrogen gas use and may overcome the limitations of current radioprotectors like amifostine.