Clinical TrialHighlighted
MHID-0848980PMID: 366757282022Journal of Personalized Medicine
Hua Lin, Jian Du, Zhigang Tian, Yonghao Yu, Yan Cui, Keliang Xie
Purpose: Postoperative delirium is a state of acute brain dysfunction characterized by fluctuating mental status that affects millions of patients each year. We used prophylactic inhalation of hydrogen gas in elderly patients undergoing elective surgery to compare their occurrence of postoperative delirium with that of controls.
Methods: A total of 184 patients aged ≥65 years were enrolled and ran
Clinical TrialObservational Study
MHID-5379845PMID: 355648082022International Journal of Environmental Research and Public Health
Gengxin Dong, Jiahui Fu, Dapeng Bao, Junhong Zhou
Background: Exercise that exceeds the body’s accustomed load can lead to oxidative stress and increased fatigue during intense training or competition, resulting in decreased athletic performance and an increased risk of injury, and the new medicinal H2 may be beneficial as an antioxidant. Therefore, we explored the effect of short-term supplementation of hydrogen-rich water (HRW) on the work perfo
Clinical Trial
MHID-7655607PMID: 365385542022PLOS ONE
Michal Valenta, Michal Botek, Jakub Krejčí, Andrew McKune, Barbora Sládečková, Filip Neuls, et al.
Purpose This study investigated the effects of acute, pre-exercise, hydrogen rich water (HRW) ingestion on running time to exhaustion at maximal aerobic speed in trained track and field runners.
Methods Twenty-four, male runners aged 17.5 ± 1.8 years, with body mass index = 21.0 ± 1.3 kgm-2, and maximal oxygen uptake = 55.0 ± 4.6 mlkg-1min-1 (mean ± standard deviation) participated in this ran
Literature Review
MHID-5798437PMID: 354938142022Frontiers in Neurology
Shin-ichi Hirano, Yusuke Ichikawa, Bunpei Sato, Yoshiyasu Takefuji, Fumitake Satoh
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disorder that is characterized by fatigue that persists for more than 6 months, weakness, sleep disturbances, and cognitive dysfunction. There are multiple possible etiologies for ME/CFS, among which mitochondrial dysfunction plays a major role in abnormal energy metabolism. The potential of many substances for the treatment of ME/CF
Clinical TrialHighlighted
MHID-6109070PMID: 362356282022Nutrients
Ahad Abdulkarim D. Alharbi, Noriaki Iwamoto, Naoyuki Ebine, Satoshi Nakae, Tatsuya Hojo, Yoshiyuki Fukuoka
This research examined the effects of single-dose molecular hydrogen (H2) supplements on acid-base status and local muscle deoxygenation during rest, high-intensity intermittent training (HIIT) performance, and recovery. Ten healthy, trained subjects in a randomized, double-blind, crossover design received H2-rich calcium powder (HCP) (1500 mg, containing 2.544 µg of H2) or H2-depleted placebo (15
Clinical Trial
MHID-7556506PMID: 352768672022Nutrients
Michal Botek, Deepesh Khanna, Jakub Krejčí, Michal Valenta, Andrew McKune, Barbora Sládečková, et al.
Hydrogen-rich water (HRW) supplementation has been shown to have an antifatigue effect across different modes of exercise. However, its effect on repeated sprint performance is unknown. The aim of this study was to assess the effect of pre-exercise HRW consumption on repeated sprint performance, lactate, and perceptual responses using a repeated sprint protocol. This randomized, double blinded, pl
Animal Study
MHID-7818899PMID: 352644922022Experimental Animals
Kohei Kawakami, Hiroyuki Matsuo, Takaya Yamada, Ken-ichi Matsumoto, Daigoro Sasaki, Masato Nomura
Hydrogen-rich water (HW) has been suggested to possess antioxidant properties of value in treatments of lifestyle diseases and for prevention of latent pathologies. To date, the potential benefits of HW against the deleterious effects of excessive salt intake and hypertension have not been investigated. Here, we first examined the effects of HW or HW supplemented with 0.1% ascorbic acid (HWA) on s
In VitroHighlighted
MHID-35766222022Processes
Subham Sharma, Johny Bajgai, Jayson M. Antonio, Ailyn Fadriquela, Thuy Thi Trinh, Md. Habibur Rahman, et al.
Diabetes is coupled with hyperglycemia, a state in which elevated glucose levels trigger oxidative stress (OS) in various body functions. One of the organs most afflicted by diabetes is the kidney. Despite this, specific treatments to mitigate the harmful effects of hyperglycemia-induced OS in the kidney have not been extensively explored. This study evaluates the anti-hyperglycemic efficacy of magne
In VitroHighlighted
MHID-02613512022Processes
Subham Sharma, Kyu-Jae Lee, Johny Bajgai, Thuy Thi Trinh, Jayson M. Antonio, Md. Habibur Rahman, et al.
Diabetes, a chronic metabolic disorder, affects glucose consumption in the body and leads to severe kidney damage, known as diabetic nephropathy, where oxidative stress (OS) plays a vital role in disease pathogenesis. Electrolyzed weakly alkaline reduced water (EWARW) is known to have anti-oxidative functions in vitro due to its bioactive properties. However, there is an increasing need for adequa
Animal Study
MHID-7787642PMID: 361994282022Oxidative Medicine and Cellular Longevity
Long Ma, Wei Hao, Wen-Bo Feng, Lu-Cheng Cao, Li-Na Qin, Yao Wang, et al.
Infertility has got to be a broadly concerned social issue these days, in which the male factor cannot be overlooked. Numerous studies have shown that electromagnetic pulse (EMP) radiation may have seriously damaging effects on reproductive health, through nonthermal effects and oxidative stress. Molecular hydrogen, a selective hydroxyl radical scavenger, explains the protective effects against many
Animal StudyIn VitroHighlighted
MHID-2681523PMID: 355281642022BioMed Research International
Xiangyan Zhang, Geru Tao, Ya’nan Zhao, Sijie Xing, Jie Jiang, Boyan Liu, et al.
Objective. Molecular hydrogen (H2) has been considered a potential therapeutic target in many cancers. Therefore, we sought to assess the potential effect of H2 on colorectal cancer (CRC) in this study.
Methods. The effect of H2 on the proliferation and apoptosis of RKO, SW480, and HCT116 CRC cell lines was assayed by CCK-8, colony formation, and flow cytometry assays. The effect of H2 on tumor growt
Observational Study
MHID-22983482022Renal Replacement Therapy
Susumu Uemura, Yoshitaka Kegasa, Keigo Tada, Taichi Tsukahara, Shigeru Kabayama, Tae Yamamoto, et al.
Background: Reportedly, dialysis solutions containing molecular hydrogen (H2) might ameliorate patient-reported fatigue in hemodialysis (HD) patients. However, it is unknown whether its impact might differ with different H2 levels.
Method: This single-arm, prospective observational study examined 105 patients on chronic HD (62 males; mean age, 66 years; mean HD duration, 117 months). All patients
Literature Review
MHID-7890987PMID: 364990792022International Journal of Molecular Sciences
Tyler W. LeBaron, Randy Sharpe, Kinji Ohno
Numerous benefits have been attributed to alkaline-electrolyzed–reduced water (ERW). Sometimes these claims are associated with easily debunked concepts. The observed benefits have been conjectured to be due to the intrinsic properties of ERW (e.g., negative oxidation–reduction potential (ORP), alkaline pH, H2 gas), as well enigmatic characteristics (e.g., altered water structure, microclusters, fre
Literature ReviewHighlighted
MHID-2004094PMID: 364988382022International Journal of Molecular Sciences
Tyler W. LeBaron, Randy Sharpe, Kinji Ohno
Many studies demonstrate the safety of alkaline-electrolyzed–reduced water (ERW); however, several animal studies have reported significant tissue damage and hyperkalemia after drinking ERW. The mechanism responsible for these results remains unknown but may be due to electrode degradation associated with the production of higher pH, in which platinum nanoparticles and other metals that have harmf
Animal StudyHighlighted
MHID-0513892PMID: 351161142022World Journal of Gastrointestinal Oncology
Fereshteh Asgharzadeh, Alex Tarnava, Asma Mostafapour, Majid Khazaei, Tyler W. LeBaron
Background: Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in the world. Tumor removal remains the preferred frontline treatment; however, effective non-surgical interventions remain a high priority. 5-fluorouracil (5-FU) is a widely used chemotherapy agent, and molecular hydrogen (H2) has been re- cognized for its antioxidant and anti-inflammatory effects, with resear
Chemical/Physicochemical StudyHighlighted
MHID-3839513PMID: 361933472022Journal of Food Science and Technology
Duried Alwazeer, Nur Özkan
Strawberries are known for their high perishability and short shelf life. The effects of incorporating hydrogen gas into sealed packaging on the quality and shelf life of strawberries were evaluated. Fruits were packaged under reducing atmosphere [RAP1 (5% CO2, 4% H2, 91% N2) and RAP2 (10% CO2, 4% H2, 86% N2)], modified atmosphere [MAP1 (5% CO2, 95% N2) and MAP2 (10% CO2, 90% N2)], and control, fol
Literature ReviewHypothesisHighlighted
MHID-3205850PMID: 359678412022Frontiers in Cellular and Infection Microbiology
Sergej M Ostojic
The molecular footprints of COVID-19 occur everywhere, even reaching the family of biologically active gases and gasotransmitters. Besides nitric oxide and hydrogen sulfide, COVID-19 might also alter the homeostasis of dihydrogen (H2), another gaseous bioactive molecule produced endogenously by the human gut bacteria. Many studies have shown various alterations of the gut microbiota in patients wit
Animal StudyHighlighted
MHID-1698660PMID: 354927052022Frontiers in Psychiatry
Noriyoshi Usui, Kazumasa Matsumoto-Miyai, Yoshihisa Koyama, Yuki Kobayashi, Yukiko Nakamura, Hikaru Kobayashi, et al.
Maternal immune activation (MIA) is triggered by infection or autoimmune predisposition during pregnancy, and cytokines produced by MIA are transmitted through the placenta to the fetal brain, implicating at the onset risks and vulnerability for developmental and psychiatric disorders, such as autism spectrum disorder (ASD) and schizophrenia. To address these kinds of problem in child health, we h
Clinical TrialHighlighted
MHID-5245813PMID: 352061792022International Journal of Environmental Research and Public Health
Michal Botek, Jakub Krejčí, Michal Valenta, Andrew McKune, Barbora Sládečková, Petr Konečný, et al.
Molecular hydrogen (H2) is potentially a novel therapeutic gas for acute post-coronavirus disease 2019 (COVID-19) patients because it has antioxidative, anti-inflammatory, anti-apoptosis, and antifatigue properties. The aim of this study was to determine the effect of 14 days of H2 inhalation on the respiratory and physical fitness status of acute post-COVID-19 patients. This randomized, single-blin
Clinical TrialHighlighted
MHID-0754862PMID: 361246532022American Journal of Clinical Nutrition
Xiang Lv, Yuanfeng Lu, Guoyong Ding, Xiao Li, Xinxin Xu, Aihua Zhang, et al.
Background: Alcohol-induced hangover represents a significant, yet understudied, global hazard and a large socioeconomic burden. Objective: The aim of this study was to investigate the effects of hydrogen on relieving drinking and hangover symptoms in 20 healthy volunteers.
Methods: In this pilot, randomized, double-blinded, placebo- controlled, matched, crossover interventional trial, participan
