Clinical Trial
MHID-0740382PMID: 386986242024International Journal of Sports Medicine
Gengxin Dong, Jianxin Wu, Yinglu Hong, Qian Li, Meng Liu, Guole Jiang, et al.
Hydrogen, as an antioxidant, may have the potential to mitigate fatigue and improve selected oxidative stress markers induced by strenuous exercise. This study focused on a previously unexplored approach involving pre-exercise inhalation of hydrogen-rich gas (HRG). Twenty-four healthy adult men first completed pre-laboratories to determine maximum cycling power (Wmax) and maximum cycling time (Tma
Clinical TrialHighlighted
MHID-9198954PMID: 397039112024PeerJ
Yuqi Zhao, Chaoqun Li, Shi Zhou, Zhiguang Xu, Xin Huang, Li Wen
Background: Inhalation of hydrogen gas (H2) as an antioxidant supplement may alleviate exercise-induced oxidative damage and protect post-exercise hydrogen peroxide signaling, which may help mediate beneficial exercise adaptation. The aims of this study were to determine the effects of H2 inhalation on plasma nitric oxide (NO) level and its synthesis precursor in professional athletes.
Methods: A
Systematic ReviewMeta-Analysis
MHID-0733746PMID: 385908282024Frontiers in Nutrition
Yiting Li, Renjie Bing, Meng Liu, Zhangyuting Shang, Yan Huang, Kaixiang Zhou, et al.
Objective: Exercise-induced oxidative stress affects multiple neurophysiological processes, diminishing the exercise performance. Hydrogen (H2) can selectively reduce excessive free radicals, but studies observed its “dual effects” on exercise-induced oxidative stress, that is, increasing or decreasing the oxidative stress. Therefore, we here conducted a systematic review and meta-analysis to quan
Animal Study
MHID-5679511PMID: 383958002024BMC Anesthesiology
Yan Cui, Yingning Li, Shuqi Meng, Yu Song, Keliang Xie
Background: Approximately 40 to 60% of patients with sepsis develop sepsis-induced cardiomyopathy (SIC), which is associated with a substantial increase in mortality. We have found that molecular hydrogen (H2) inhalation improved the survival rate and cardiac injury in septic mice. However, the mechanism remains unclear. This study aimed to explore the regulatory mechanism by which hydrogen modula
Animal Study
MHID-3239928PMID: 386383342024Frontiers in Pharmacology
Weiming Yan, Qiurui He, Pan Long, Tao Chen, Lei Zhang, Haiyan Wang
Objective Our research was performed in order to explore the effects of molecular hydrogen (H2), a novely-established antioxidant, on the retinal degeneration in rd1 mice, an animal model of inherited retinitis pigmentosa (RP).
Methods The rd1 mice were divided randomly into control and H2 intervention groups. Mice from other groups received H2 intervention in three modes, two modes of the hydrog
Clinical TrialAnimal StudyHighlighted
MHID-3437190PMID: 391167822024Biomedicine & Pharmacotherapy
Bing Xie, Yong Wang, Yun Lu, Mengmeng Wang, Rongji Hui, Hailei Yu, et al.
The gut-brain axis mediates the interaction pathway between microbiota and opioid addiction. In recent years, many studies have shown that molecular hydrogen has therapeutic and preventive effects on various diseases. This study aimed to investigate whether molecular hydrogen could serve as pharmacological intervention agent to reduce risks of reinstatement of opioid seeking and explore the mechan
Clinical TrialHighlighted
MHID-7865618PMID: 394347212024Frontiers in Physiology
Kaixiang Zhou, Chaoqun Yuan, Zhangyuting Shang, Wenhui Jiao, Yubo Wang
Background: Exercise-induced oxidative stress and inflammation can impair muscular function in humans. The antioxidant and anti-inflammatory properties of molecular hydrogen (H2) highlight its potential to be as an effective nutritional supplement to support muscular function performance in healthy adults. However, the effects of H2 supplementation on muscular endurance performance in trained indivi
Clinical TrialHighlighted
MHID-1498378PMID: 392581912024Heliyon
Fenglin Wu, Jun Ma, Junli Xue, Xue Jiang, Jinyu Liu, Jiashuo Zhang, et al.
Background: Consumption of hydrogen-rich water (HRW) has been shown to have anti- inflammatory and metabolic-modulatory benefits.
Objective: A randomized, placebo-controlled trial was conducted to assess the potential blood uric acid-lowering effects of HRW consumption with different doses (low and high doses) and duration (4 and 8 weeks) in patients with hyperuricemia.
Methods: The Placebo grou
In VivoHighlighted
MHID-2254695PMID: 396409892024Frontiers in Plant Science
Renyuan Wang, Xijia Yang, Yaowei Chi, Xia Zhang, Xianzhong Ma, Dan Zhang, et al.
Salt stress could lead to plant growth barriers and crop yield reduction. Strawberries are sensitive to salt stress, and improving salt tolerance is important for strawberry production. This study aimed to explore the potential of hydrogen-rich water (HRW) to enhance salt tolerance in strawberries. Through pot experiments, we investigated how HRW affects plant growth, ion absorption, osmotic stres
Clinical TrialHighlighted
MHID-4782143PMID: 387947672024Nutrients
Yineng Tan, Yixun Xie, Gengxin Dong, Mingyue Yin, Zhangyuting Shang, Kaixiang Zhou, et al.
Background: Hydrogen (H2) may be a potential therapeutic agent for managing Long COVID symptoms due to its antioxidant and anti-inflammatory properties. However, more scientific literature is needed to describe the effects of H2 administration on treating symptoms. A study aimed to investigate the impact of hydrogen-rich water (HRW) administration on the fatigue and dyspnea of Long-COVID patients
Animal StudyHighlighted
MHID-3306838PMID: 394567942024International Journal of Molecular Sciences
Dmitrii Atiakshin, Andrey Kostin, Alexander Alekhnovich, Artem Volodkin, Michael Ignatyuk, Ilya Klabukov, et al.
Molecular hydrogen (H2) has antioxidant, anti-inflammatory, and anti-fibrotic effects. In a rat model simulating pulmonary fibrotic changes induced by monocrotaline-induced pulmonary hypertension (MPH), we had previously explored the impact of inhaled H2 on lung inflammation and blood pressure. In this study, we further focused the biological effects of H2 on mast cells (MCs) and the parameters of
Animal StudyHighlighted
MHID-3793036PMID: 394330132024International Immunopharmacology
Shuaijie Pei, Lina Zheng, Zhigang Tian, Shuqi Meng, Zhiwei Wang, Yan Fan, et al.
Sepsis is a major cause of mortality among critical patients. Acute kidney injury (AKI) is the common complication in patients with sepsis, characterized by rapid deterioration of renal function. The purpose of this study is to assess the impact of inhaling high concentration hydrogen on septic mice with AKI and to examine the involvement of mitochondria in this process. High concentration hydroge
Literature Review
MHID-0933508PMID: 394529182024Metabolites
Qiaorui Zhou, Huixin Li, Ye Zhang, Yirui Zhao, Can Wang, Chang Liu
Background: Hydrogen-rich water (HRW) has garnered significant interest within the sports and exercise science community due to its selective antioxidant properties. Despite its potential benefits, comprehensive reviews specifically addressing its effects on athletic performance are limited. This review aims to assess the impact of HRW on sports performance and explore the underlying molecular bio
Literature Review
MHID-9326458PMID: 379295072024Medical Gas Research
Jin Cheng, Minmin Shi, Xuejun Sun, Hongtao Lu
Hydrogen is a simple, colorless, and biologically active small molecule gas that can react with reactive oxygen species. Recent research suggests that hydrogen possesses several biological effects, including antioxidant, anti-inflammatory, and anti-apoptotic effects, while exhibiting an extremely high level of safety. Hydrogen application has shown promise in treating a range of acute and chronic
Systematic ReviewMeta-AnalysisHighlighted
MHID-4133017PMID: 392110452024Frontiers in Immunology
Kang Xiao, Jianwei Liu, Yuxin Sun, Shangya Chen, Jiazi Ma, Mao Cao, et al.
As a small molecule, hydrogen is colorless, odorless and lightest. Many studies conducted that hydrogen can protect almost every organ, including the brain, heart muscle, liver, small intestine, and lungs. To verify whether high concentrations of hydrogen (HCH) has anti-inflammatory and antioxidant activities on respiratory system, we product a systematic review and meta- analysis. We investigated
Literature Review
MHID-87403452024Molecular Hydrogen in Health and Disease
Yunbo Xie, Guohua Song
It has been demonstrated that hydrogen molecules possess biological effects, and furthermore, they are colorless, non-toxic, and have a small molecular weight, enabling them to traverse the blood–brain barrier. This review synthesizes more than 100 publications on the use of hydrogen therapy in clinical ailments and categorizes the applications of hydrogen medicine into nine major systemic disease
Literature Review
MHID-9342689PMID: 371112992023Pharmaceuticals
Fei Xie, Yifei Song, Yang Yi, Xue Jiang, Shiwen Ma, Chen Ma, et al.
Oxidative stress and chronic inflammation have been implicated in the pathophysiology of metabolic diseases, including diabetes mellitus (DM), metabolic syndrome (MS), fatty liver (FL), atherosclerosis (AS), and obesity. Molecular hydrogen (H2) has long been considered a physiologically inert gas. In the last two decades, accumulating evidence from pre-clinical and clinical studies has indicated th
Observational Study
MHID-6877147PMID: 365168982023Brain Research Bulletin
Yong Wang, Mengmeng Wang, Bing Xie, Di Wen, Wenbo Li, Meiqi Zhou, et al.
Methamphetamine (METH) is a potent and highly addictive psychostimulant and one of the most widely used illicit drugs, the abuse of which has become a severe public health problem worldwide. A growing amount of evidence has indicated potential connections between gut microbiota and mental disorders induced by METH and associations with neural and metabolic pathways. The present study aimed to expl
Animal Study
MHID-6003573PMID: 364684152023CNS Neuroscience & Therapeutics
Qingqing Han, Yuanyuan Bai, Chunjing Zhou, Beibei Dong, Yingning Li, Ning Luo, et al.
Introduction: In our experiments, male wild-type mice were randomly divided into four groups: the sham, SAE, SAE + 2% hydrogen gas inhalation (H2), and SAE + hydrogen-rich water (HW) groups. The feces of the mice were collected for 16 S rDNA analysis 24 h after the models were established, and the serum and brain tissue of the mice were collected for nontargeted metabolomics analysis.
Aim: Destru
Literature Review
MHID-5981744PMID: 370771212023Medical Gas Research
He Li, Hong-Yu Ma, Wei-Long Hua, Yong-Xin Zhang, Lei Zhang, Peng-Fei Xing, et al.
The medical use of molecular hydrogen, including hydrogen-rich water and hydrogen gas, has been extensively explored since 2007. This article aimed to demonstrate the trend in medical research on molecular hydrogen. A total of 1126 publications on hydrogen therapy were retrieved from the PubMed database until July 30, 2021. From 2007 to 2020, the number of publications in this field had been on an
