Animal StudyIn VitroHighlighted
MHID-7164222PMID: 227767732012Medical Gas Research
Masanori Katakura, Michio Hashimoto, Yoko Tanabe, Osamu Shido
Background: Reactive oxygen species (ROS) production induced by α,β-dicarbonyl compounds and advanced glycation end products causes renal dysfunction in patients with type 2 diabetes and metabolic syndrome. Hydrogen-rich water (HRW) increases the H2 level in blood and tissues, thus reducing oxidative stress in animals as well as humans. In this study, we investigated the effects of HRW on glucose-
Literature ReviewAnimal StudyHighlighted
MHID-2487138PMID: 257255222011Parkinson’s Disease
Kyota Fujita, Yusaku Nakabeppu, Mami Noda
Since the first description of Parkinson’s disease (PD) nearly two centuries ago, a number of studies have revealed the clinical symp- toms, pathology, and therapeutic approaches to overcome this intractable neurodegenerative disease. 1-methy-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA) are neurotoxins which produce Parkinsonian pathology. From the animal studies using
Human StudyLiterature ReviewAnimal StudyIn VitroHighlighted
MHID-1756030PMID: 221460822011Medical Gas Research
Shigeo Ohta, Atsunori Nakao, Kinji Ohno
This report summarizes a brief description/history of the Hydrogen Research Meetings as well as key presentations/oral abstracts delivered in the most recent symposium. Additionally, we introduced 38 diseases and physiological states for which hydrogen exhibits beneficial effects.
Clinical TrialHighlighted
MHID-2481572PMID: 221466742011Medical Gas Research
Mikako Ito, Tohru Ibi, Ko Sahashi, Masashi Ichihara, Masafumi Ito, Kinji Ohno
Background: Molecular hydrogen has prominent effects on more than 30 animal models especially of oxidative stress-mediated diseases and inflammatory diseases. In addition, hydrogen effects on humans have been reported in diabetes mellitus type 2, hemodialysis, metabolic syndrome, radiotherapy for liver cancer, and brain stem infarction. Hydrogen effects are ascribed to specific radical-scavenging
Animal StudyIn VitroHighlighted
MHID-1458727PMID: 217232542011Biochemical and Biophysical Research Communications
Tomohiro Itoh, Nanako Hamada, Riyako Terazawa, Mikako Ito, Kinji Ohno, Masatoshi Ichihara, et al.
Molecular hydrogen has been reported to be effective for a variety of disorders and its effects have been ascribed to the reduction of oxidative stress. However, we have recently demonstrated that hydrogen inhibits type I allergy through modulating intracellular signal transduction. In the present study, we examined the hydrogen effects on lipopolysaccharide/interferon c LPS/IFNc-induced nitric ox
Clinical TrialHighlighted
MHID-4803545PMID: 221460042011Medical Gas Research
Ki-Mun Kang, Young-Nam Kang, Ihil-Bong Choi, Yeunhwa Gu, Tomohiro Kawamura, Yoshiya Toyoda, et al.
Background: Cancer patients receiving radiotherapy often experience fatigue and impaired quality of life (QOL). Many side effects of radiotherapy are believed to be associated with increased oxidative stress and inflammation due to the generation of reactive oxygen species during radiotherapy. Hydrogen can be administered as a therapeutic medical gas, has antioxidant properties, and reduces inflam
Animal StudyHighlighted
MHID-2760312PMID: 221460832011Medical Gas Research
Michio Hashimoto, Masanori Katakura, Toru Nabika, Yoko Tanabe, Shahdat Hossain, Satoru Tsuchikura, et al.
Background: Hydrogen (H2), a potent free radical scavenger, selectively reduces the hydroxyl radical, which is the most cytotoxic of the reactive oxygen species (ROS). An increase in oxygen free radicals induces oxidative stress, which is known to be involved in the development of metabolic syndrome. Therefore, we investigated whether hydrogen-rich water (HRW) affects metabolic abnormalities in th
In VitroObservational Study
MHID-9621518PMID: 220709002011Journal of Photochemistry and Photobiology B: Biology
Shinya Kato, Yasukazu Saitoh, Keizou Iwai, Nobuhiko Miwa
Hydrogen-rich electrolyzed warm water (HW) was prepared at 41ºC and exhibited dissolved hydrogen (DH) of 1.13 ppm and an oxidation-reduction potential (ORP) of -741 mV in contrast to below 0.01 ppm and +184 mV for regular warm water (RW).
Fibroblasts OUMS-36 and keratinocytes HaCaT were used to examine effects of HW against UVA-ray irradiation. Type-I collagen was synthesized 1.85- to 2.03-fold m
Animal StudyIn Vitro
MHID-5661317PMID: 223730562011BMC Proceedings
Sanetaka Shirahata, Takeki Hamasaki, Keisuke Haramaki, Takuro Nakamura, Masumi Abe, Hanxu Yan, et al.
Electrochemically reduced water (ERW) contains a lot of hydrogen molecule (H2) and scavenges reactive oxygen species (ROS) to protect DNA from oxidative damage [1]. ERW also contains small amounts of Pt nanoparticles (NPs) and elongates the lifespan of C. elegans [2]. Pt NPs are newly recognized multi-functional ROS scavengers [3]. ERW exhibits anti-diabetes effects in vitro and in vivo [4-6][7].
Animal StudyHighlighted
MHID-9017895PMID: 208883922010Neuroscience Letters
Ying Lin, Akinori Kashio, Takashi Sakamoto, Keigo Suzukawa, Akinobu Kakigi, Tatsuya Yamasoba
It has been shown that molecular hydrogen acts as a therapeutic and preventive antioxidant by selectively reducing the hydroxyl radical, the most cytotoxic of the reactive oxygen species. In the present study, we tested the hypothesis that acoustic damage in guinea pigs can be attenuated by the consumption of molecular hydrogen. Guinea pigs received normal water or hydrogen-rich water for 14 days
Animal StudyHighlighted
MHID-7978470PMID: 198340322010Investigative Ophthalmology & Visual Science
Hideaki Oharazawa, Tsutomu Igarashi, Takashi Yokota, Hiroaki Fujii, Hisaharu Suzuki, Mitsuru Machide, et al.
PURPOSE. Retinal ischemia-reperfusion (I/R) injury by transient
elevation of intraocular pressure (IOP) is known to induce
neuronal damage through the generation of reactive oxygen
species. Study results have indicated that molecular hydrogen
(H2) is an efficient antioxidant gas that selectively reduces the
hydroxyl radical (OH) and suppresses oxidative stress-induced
injury in several organs. This
In VitroHighlighted
MHID-9110946PMID: 210427402010Oncology Reports
Ryoko Asada, KATSUHIRO KAGEYAMA, HIROSHI TANAKA, HISAKAZU MATSUI, MASATSUGU KIMURA, Yasukazu Saitoh, et al.
In order to erase reactive oxygen species (ROS) related with the proliferation of tumor cells by reducing activity of hydrogen, we developed functional water containing nano-bubbles (diameters: <900 nm for 71%/ population) hydrogen of 1.1-1.5 ppm (the theoretical maximum: 1.6 ppm) with a reducing ability (an oxidation- reduction potential -650 mV, normal water: +100-200 mV) using a microporous-fil
Animal StudyHighlighted
MHID-8852067PMID: 197896282009PLoS ONE
Kyota Fujita, Toshihiro Seike, Noriko Yutsudo, Mizuki Ohno, Hidetaka Yamada, Hiroo Yamaguchi, et al.
It has been shown that molecular hydrogen (H2) acts as a therapeutic antioxidant and suppresses brain injury by buffering the effects of oxidative stress. Chronic oxidative stress causes neurodegenerative diseases such as Parkinson’s disease (PD). Here, we show that drinking H2-containing water significantly reduced the loss of dopaminergic neurons in PD model mice using both acute and chronic adm
Animal StudyHighlighted
MHID-3088793PMID: 193565982009Neuroscience Letters
Yuan Fu, Mikako Ito, Yasunori Fujita, Masafumi Ito, Masatoshi Ichihara, Akio Masuda, et al.
Molecular hydrogen serves as an antioxidant that reduces hydroxyl radicals, but
not the other reactive oxygen and nitrogen species. In the past year, molecular hydrogen
has been reported to prevent or ameliorate eight diseases in rodents and one in human
associated with oxidative stress. In Parkinson’s disease, mitochondrial dysfunction and
the associated oxidative stress are major causes of dopam
Animal StudyIn VitroHighlighted
MHID-5929908PMID: 191486452009Cancer Chemotherapy and Pharmacology
Naomi Nakashima-Kamimura, Takashi Mori, Ikuroh Ohsawa, Sadamitsu Asoh, Shigeo Ohta
Purpose: Cisplatin is a widely used anti-cancer drug in the treatment of a wide range of tumors; however, its application is limited by nephrotoxicity, which is affected by oxidative stress. We have reported that molecular hydrogen (H(2)) acts as an efficient antioxidant (Ohsawa et al. in Nat Med 13:688-694, 2007). Here we show that hydrogen efficiently mitigates the side effects of cisplatin by r
Animal StudyHighlighted
MHID-6761448PMID: 185630582009Neuropsychopharmacology
Kazufumi Nagata, Naomi Nakashima-Kamimura, Toshio Mikami, Ikuroh Ohsawa, Shigeo Ohta
We have reported that hydrogen (H2) acts as an efficient antioxidant by gaseous rapid diffusion. When water saturated with hydrogen (hydrogen water) was placed into the stomach of a rat, hydrogen was detected at several mM level in blood. Because hydrogen gas is unsuitable for continuous consumption, we investigated using mice whether drinking hydrogen water ad libitum, instead of inhaling hydroge
Animal StudyHighlighted
MHID-8903197PMID: 176731692007Biochemical and Biophysical Research Communications
Kei-ichi Fukuda, Sadamitsu Asoh, Masahiro Ishikawa, Yasuhiro Yamamoto, Ikuroh Ohsawa, Shigeo Ohta
We have recently showed that molecular hydrogen has great potential for selectively reducing cytotoxic reactive oxygen species, such as hydroxyl radicals, and that inhalation of hydrogen gas decreases cerebral infarction volume by reducing oxidative stress [I. Ohsawa, M. Ishikawa, K. Takahashi, M. Watanabe, K. Nishimaki, K. Yamagata, K.-I. Katsura, Y. Katayama, S. Asoh, S. Ohta, Hydrogen acts as a
Animal StudyIn VitroHighlighted
MHID-7700658PMID: 174860892007Nature Medicine
Ikuroh Ohsawa, Masahiro Ishikawa, Kumiko Takahashi, Megumi Watanabe, Kiyomi Nishimaki, Kumi Yamagata, et al.
Acute oxidative stress induced by ischemia-reperfusion or inflammation causes serious damage to tissues, and persistent oxidative stress is accepted as one of the causes of many common diseases including cancer. We show here that hydrogen (H2) has potential as an antioxidant in preventive and therapeutic applications. We induced acute oxidative stress in cultured cells by three independent methods.
