Clinical TrialHighlighted
MHID-5245813PMID: 352061792022International Journal of Environmental Research and Public Health
Michal Botek, Jakub Krejčí, Michal Valenta, Andrew McKune, Barbora Sládečková, Petr Konečný, et al.
Molecular hydrogen (H2) is potentially a novel therapeutic gas for acute post-coronavirus disease 2019 (COVID-19) patients because it has antioxidative, anti-inflammatory, anti-apoptosis, and antifatigue properties. The aim of this study was to determine the effect of 14 days of H2 inhalation on the respiratory and physical fitness status of acute post-COVID-19 patients. This randomized, single-blin
Clinical TrialHighlighted
MHID-1269854PMID: 362782212022Frontiers in Pharmacology
Boyan Liu, Xue Jiang, Yunbo Xie, Xiubin Jia, Jiashuo Zhang, Yazhuo Xue, et al.
Objective: To explore the effect of a low-dose hydrogen–oxygen (H2-O2) mixture inhalation in midlife/older adults with hypertension.
Methods: This randomized, placebo-controlled trial included 60 participants with hypertension aged 50–70 years who were randomly divided into Air group (inhaled placebo air) or H2-O2 group [inhaled H2-O2 mixture (66% H2/33% O2)]. Participants in both groups were tre
Animal StudyHighlighted
MHID-2655528PMID: 352732492022Scientific Reports
Yao Mawulikplimi Adzavon, Fei Xie, Yang Yi, Xue Jiang, Xiaokang Zhang, Jin He, et al.
Molecular hydrogen (H2) has emerged as a new therapeutic option in several diseases and is widely adopted by healthy people. However, molecular data to support therapeutic functions attributed to the biological activities of H2 remain elusive. Here, using transcriptomic and metabolomic approaches coupled with biochemistry and micro-CT technics, we evaluated the effect of long-term (6 months) and d
Literature Review
MHID-9272690PMID: 330783742021Neuroscience Bulletin
Wei Chen, Han-Ting Zhang, Shu-Cun Qin
Molecular hydrogen (H2) is a physiologically inert gas. However, during the last 10 years, increasing evidence has revealed its biological functions under pathological conditions. More specifically, H2 has protec- tive effects against a variety of diseases, particularly nervous system disorders, which include ischemia/reperfu- sion injury, traumatic injury, subarachnoid hemorrhage, neuropathic pain
Literature Review
MHID-6029476PMID: 346464232021Oxidative Medicine and Cellular Longevity
Duried Alwazeer, Franky Fuh-Ching Liu, Xiao Yu Wu, Tyler W. LeBaron
COVID-19 is a widespread global pandemic with nearly 185 million confirmed cases and about four million deaths. It is caused by an infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which primarily affects the alveolar type II pneumocytes. The infection induces pathological responses including increased inflammation, oxidative stress, and apoptosis. This situation result
Literature Review
MHID-48068842021Hydrogen
Grace Russell, Alexander Nenov, Hesham Kisher, John T. Hancock
Since the late 18th century, molecular hydrogen (H2) has been shown to be well tolerated, firstly in animals, and then in humans. However, although research into the beneficial effects of molecular hydrogen in both plant and mammalian physiology is gaining momentum, the idea of utilising this electrochemically neutral and non-polar diatomic compound for the benefit of health has yet to be widely acce
Literature Review
MHID-5326803PMID: 349874192021Frontiers in Physiology
Yan Tian, Yafang Zhang, Yu Wang, Yunxi Chen, Weiping Fan, Jianjun Zhou, et al.
Molecular hydrogen (H2) is a colorless and odorless gas. Studies have shown that H2 inhalation has the therapeutic effects in many animal studies and clinical trials, and its application is recommended in the novel coronavirus pneumonia treatment guidelines in China recently. H2 has a relatively small molecular mass, which helps it quickly spread and penetrate cell membranes to exert a wide range
Clinical TrialHighlighted
MHID-1947207PMID: 346511332021Critical Care Explorations
Alexis R. Cole, BS, Francesca Sperotto, MD, James A. DiNardo, MD, Stephanie Carlisle, Michael J. Rivkin, MD, Lynn A. Sleeper, ScD, et al.
BACKGROUND: Ischemia-reperfusion injury is common in critically ill patients, and directed therapies are lacking. Inhaled hydrogen gas diminishes ischemia-reperfusion injury in models of shock, stroke, and cardiac arrest. The purpose of this study was to investigate the safety of inhaled hydrogen gas at doses required for a clinical efficacy study.
DESIGN: Prospective, single-arm study.
SETTING: T
Animal StudyHighlighted
MHID-8428241PMID: 331161632020Scientific Reports
Zhi‑ming Xun, Qing‑hui Zhao, Yan Zhang, Fang‑di Ju, Jin He, Ting‑ting Yao, et al.
The potential therapeutic effects of molecular hydrogen (H2) have now been confirmed in various human and animal-disease models. However, the effects of H2 on the physiological function in a normal state have been largely neglected. Hydrogen-rich water (HRW) intake and hydrogen inhalation (HI) are the most common used methods for hydrogen administration, the difference in the effects between HRW i
Literature Review
MHID-3461972PMID: 309702152019Canadian Journal of Physiology and Pharmacology
Tyler W. LeBaron, Ismail Laher, Branislav Kura, Jan Slezak
H2 has been clinically demonstrated to provide antioxidant and anti-inflammatory effects, which makes it an attractive agent in exercise medicine. Although exercise provides a multiplicity of benefits including decreased risk of disease, it can also have detrimental effects. For example, chronic high-intensity exercise in elite athletes, or sporadic bouts of exercise (i.e. noxious exercise) in unt
Clinical TrialHighlighted
MHID-0587967PMID: 319380042019Biology of Sport
Dejan Javorac, Valdemar Stajer, Laszlo Ratgeber, Jozsef Betlehem, Sergej Ostojic
In this randomized, double-blind, placebo-controlled, crossover pilot trial, we evaluated the effects of 7-day H2 inhalation on exercise performance outcomes and serum hormonal and inflammation profiles in a cohort of young men and women. All participants (age 22.9 ± 1.5 years; body mass index 23.4 ± 2.5 kg m-2; 10 women and 10 men) were allocated to receive either gaseous hydrogen (4%) or placebo
Clinical Trial
MHID-0476956PMID: 307136662018Medical Gas Research
Masaaki Hirayama, Mikako Ito, Tomomi Minato, Asako Yoritaka, Tyler W. LeBaron, Kinji Ohno
Hyposmia is one of the earliest and the most common symptoms in Parkinson’s disease (PD). The benefits of hydrogen water on motor deficits have been reported in animal PD models and PD patients, but the effects of hydrogen gas on PD patients have not been studied. We evaluated the effect of inhalation of hydrogen gas on olfactory function, non-motor symptoms, activities of daily living, and urinar
Literature Review
MHID-31863052018Asia-Pacific Journal of Blood Types and Genes
Jinqi Li, Yan Zang, Haihui Gu, Baohua Qian
Hydrogen (H2) is a colorless, odorless gas that can act as a reducing agent under certain circumstances. Previously considered physiologically an inert and nonfunctional molecule in mammalian cells, H2 largely went ignored until Nature Medicine revealed the antioxidant and cytoprotective effects of hydrogen gas in a focal stroke model. Reactive oxygen species (ROS) is generated inside the body thr
Clinical TrialHighlighted
MHID-0517534PMID: 346542212018European Geriatric Medicine
Darinka Korovljev, Valdemar Stajer, Dejan Javorac, Sergej M Ostojic
Molecular hydrogen (H2) has been recently introduced as an experimental medical gas in clinical medicine [1]. Beneficial effects of H2 are attributed to its antioxidant, anti-apoptotic and anti-inflammatory properties, with H2 administered via oral, parenteral or inhalational route found beneficial in cardiometabolic disorders [2]. However, no information is currently available concerning its effi
Clinical TrialHighlighted
MHID-7349011PMID: 286696542017Journal of Stroke and Cerebrovascular Diseases
Hirohisa Ono, MD, Yoji Nishijima, MD, Shigeo Ohta, PhD, Masaki Sakamoto, MD, Kazunori Kinone, MD, Tohru Horikosi, MD, et al.
Background: Molecular hydrogen (H2) acts as a therapeutic antioxidant. Inhalation of H2 gas (1-4%) was effective for the improvement of cerebral infarction in multiple animal experiments. Thus, for actual applications, a randomized con- trolled clinical study is desired to evaluate the effects of inhalation of H2 gas. Here, we evaluate the H2 treatment on acute cerebral infarction.
Methods: Throu
Literature Review
MHID-0365812PMID: 282172942016Medical Gas Research
Lei Huang
Molecular hydrogen (H2) medicine research has flourished since a landmark publication in Nature Medicine that revealed the antioxidant and cytoprotective effects of hydrogen gas in a focal stroke model. Emerging evidence has consistently demonstrated that molecular hydrogen is a promising therapeutic option for a variety of diseases and the underlying comprehensive mechanisms is beyond pure hydrox
Literature ReviewHighlighted
MHID-7479916PMID: 264839532015Medical Gas Research
Masatoshi Ichihara, Sayaka Sobue, Mikako Ito, Masafumi Ito, Masaaki Hirayama, Kinji Ohno
Therapeutic effects of molecular hydrogen for a wide range of disease models and human diseases have been investigated since 2007. A total of 321 original articles have been published from 2007 to June 2015. Most studies have been conducted in Japan, China, and the USA. About three-quarters of the articles show the effects in mice and rats. The number of clinical trials is increasing every year. I
HypothesisHighlighted
MHID-49572952011Medical Science Monitor
Yunhai Chuai, Luqian Zhao, Jin Ni, Ding Sun, Jianguo Cui, Bailong Li, et al.
Radiotherapy is an important modality of cancer treatment. Radiation pneumonitis is a major obstacle to increasing the radiation dose in radiotherapy, and it is important to prevent this radiation-induced complication. Recent studies show that hydrogen has a potential as an effective and safe radioprotective agent by selectively reducing hydroxyl and peroxynitrite radicals. Since most of the ioniz
Human StudyLiterature ReviewAnimal StudyIn VitroHighlighted
MHID-1756030PMID: 221460822011Medical Gas Research
Shigeo Ohta, Atsunori Nakao, Kinji Ohno
This report summarizes a brief description/history of the Hydrogen Research Meetings as well as key presentations/oral abstracts delivered in the most recent symposium. Additionally, we introduced 38 diseases and physiological states for which hydrogen exhibits beneficial effects.
HypothesisHighlighted
MHID-5193561PMID: 196648842010Medical Hypotheses
Cong Liu, Jianguo Cui, Quan Sun, Jianming Cai
Hydrogen is the most abundant chemical element in the universe, however, it is seldom regarded as a therapeutic gas. Recent studies show that inhaled hydrogen gas (H2) has antioxidant and antiapoptotic activities that protect the brain against ischemia–reperfusion injury and stroke by selectively reducing hydroxyl and peroxynitrite radicals. It is also well known that more than a half of the ioniz
