Other
MHID-1413948PMID: 390733352024Medical Gas Research
Yusuke Ichikawa, Bunpei Sato, Shin-ichi Hirano, Yoshiyasu Takefuji, Fumitake Satoh
The Michael J. Fox Foundation has been funding research on Parkinson’s disease for 35 years, but has yet to find a cure. This is due to a problem with the philosophy behind the development of modern medical treatments. In this paper, we will introduce “smart medicine” with a substance that can solve all the problems of central nervous system drugs. The substance is the smallest diatomic molecule,
Literature Review
MHID-9326458PMID: 379295072024Medical Gas Research
Jin Cheng, Minmin Shi, Xuejun Sun, Hongtao Lu
Hydrogen is a simple, colorless, and biologically active small molecule gas that can react with reactive oxygen species. Recent research suggests that hydrogen possesses several biological effects, including antioxidant, anti-inflammatory, and anti-apoptotic effects, while exhibiting an extremely high level of safety. Hydrogen application has shown promise in treating a range of acute and chronic
Systematic ReviewMeta-AnalysisHighlighted
MHID-4133017PMID: 392110452024Frontiers in Immunology
Kang Xiao, Jianwei Liu, Yuxin Sun, Shangya Chen, Jiazi Ma, Mao Cao, et al.
As a small molecule, hydrogen is colorless, odorless and lightest. Many studies conducted that hydrogen can protect almost every organ, including the brain, heart muscle, liver, small intestine, and lungs. To verify whether high concentrations of hydrogen (HCH) has anti-inflammatory and antioxidant activities on respiratory system, we product a systematic review and meta- analysis. We investigated
Literature Review
MHID-5103861PMID: 398081702024Physiological Research
Jan Slezak, Tatiana Ravingerova, Branislav Kura
Disproportion between reactive oxygen species (ROS) production and the body's antioxidant system can cause oxidative stress, which is considered a common denominator in various pathological conditions, including cardiovascular diseases, aging, and cognitive disorders. The generation of free radicals, which occurs through partial reduction of oxygen, can quickly overwhelm the endogenous antioxidant
Animal StudyObservational StudyHighlighted
MHID-6966642PMID: 402326942024Medical Gas Research
Yusuke Ichikawa, Bunpei Sato, Shin-ichi Hirano, Yoshiyasu Takefuji, Fumitake Satoh
Amyotrophic lateral sclerosis (ALS) is a motor neuron disease, a neurodegenerative disorder characterized by sporadic and progressive degenerative loss of cell bodies of both the upper and lower motor neurons. Clinical manifestations of ALS are known to include lower motor neuron symptoms, upper motor neuron symptoms, bulboparesthesia symptoms, cognitive dysfunction, and negative signs. Dissociate
Literature Review
MHID-9342689PMID: 371112992023Pharmaceuticals
Fei Xie, Yifei Song, Yang Yi, Xue Jiang, Shiwen Ma, Chen Ma, et al.
Oxidative stress and chronic inflammation have been implicated in the pathophysiology of metabolic diseases, including diabetes mellitus (DM), metabolic syndrome (MS), fatty liver (FL), atherosclerosis (AS), and obesity. Molecular hydrogen (H2) has long been considered a physiologically inert gas. In the last two decades, accumulating evidence from pre-clinical and clinical studies has indicated th
Literature ReviewOtherHighlighted
MHID-7822057PMID: 362047812023Medical Gas Research
Yusuke Ichikawa, Shin-ichi Hirano, Bunpei Sato, Haru Yamamoto, Yoshiyasu Takefuji, Fumitake Satoh
Despite the fact that we have reported on the dangers of the explosion of hydrogen gas inhalers, hydrogen gas inhalers with explosive hazards are, as a matter of fact, still being sold today. In this study, we investigated past reports of hydrogen gas inhaler explosion accidents to clarify the causes of these explosion incidents. As a result of this investigation, we found that the central cause w
Observational Study
MHID-6877147PMID: 365168982023Brain Research Bulletin
Yong Wang, Mengmeng Wang, Bing Xie, Di Wen, Wenbo Li, Meiqi Zhou, et al.
Methamphetamine (METH) is a potent and highly addictive psychostimulant and one of the most widely used illicit drugs, the abuse of which has become a severe public health problem worldwide. A growing amount of evidence has indicated potential connections between gut microbiota and mental disorders induced by METH and associations with neural and metabolic pathways. The present study aimed to expl
Animal Study
MHID-6003573PMID: 364684152023CNS Neuroscience & Therapeutics
Qingqing Han, Yuanyuan Bai, Chunjing Zhou, Beibei Dong, Yingning Li, Ning Luo, et al.
Introduction: In our experiments, male wild-type mice were randomly divided into four groups: the sham, SAE, SAE + 2% hydrogen gas inhalation (H2), and SAE + hydrogen-rich water (HW) groups. The feces of the mice were collected for 16 S rDNA analysis 24 h after the models were established, and the serum and brain tissue of the mice were collected for nontargeted metabolomics analysis.
Aim: Destru
Animal Study
MHID-0385819PMID: 358952452023Journal of Neuroimmune Pharmacology
Wan‑Chao Yang, Ting‑ting Li, Qiang Wan, Xin Zhang, Li‑Ying Sun, Yu‑Rong Zhang, et al.
Diabetes is an independent risk factor for stroke and amplifies inflammation. Diabetic stroke is associated with a higher risk of death and worse neural function. The identification of effective anti-inflammatory molecules with translational advantages is particularly important to promote perioperative neurorestorative effects. Applying molecular hydrogen, we measured blood glucose levels before a
Literature Review
MHID-61283312023SciBase Clinical and Medical Case Reports
Grace Russell, Alexander Nenov
Human reproductive health is an integral part of personal well-being that can markedly impact upon individuals, couples,
families and the wider society. It is estimated that infertility affects 13 to 15% of the world’s population and with parents often
deciding to delay planning for pregnancy until later in life, age-related concerns about the viability of female oocytes, in partic
ular, are at th
Literature Review
MHID-1879460PMID: 378931902023Biomedicines
Shin-ichi Hirano, Yusuke Ichikawa, Bunpei Sato, Yoshiyasu Takefuji, Fumitake Satoh
As diabetes rates surge globally, there is a corresponding rise in the number of patients suffering from diabetic kidney disease (DKD), a common complication of diabetes. DKD is a significant contributor to chronic kidney disease, often leading to end-stage renal failure. However, the effectiveness of current medical treatments for DKD leaves much to be desired. Molecular hydrogen (H2) is an antio
Animal StudyHighlighted
MHID-2957577PMID: 381373622023Biomedicines
Tatyana Kuropatkina, Dmitrii Atiakshin, Fedor Sychev, Marina Artemieva, Tatyana Samoilenko, Olga Gerasimova, et al.
Hydrogen has been shown to exhibit selective antioxidant properties against hydroxyl radicals, and exerts antioxidant and anti-inflammatory effects. The monocrotaline-induced model of pulmonary hypertension is suitable for studying substances with antioxidant activity because oxidative stress is induced by monocrotaline.
On day 1, male Wistar rats were subcutaneously injected with a water–alcohol
Systematic ReviewHighlighted
MHID-3427886PMID: 373542432023Asian Pacific Journal of Cancer Prevention
Muhammad Nooraiman Zufayri Mohd Noor, Adlin Sofea Alauddin, Yin How Wong, Chung Yeng Looi, Eng Hwa Wong, Priya Madhavan, et al.
Background: Cancer remains a challenging target to cure, with present therapeutic methods unable to exhibit restorative outcomes without causing severe negative effects. Molecular hydrogen (H2) has been reported to be a promising adjunctive therapy for cancer treatment, having the capability to induce anti-proliferative, anti-oxidative, pro-apoptotic and anti-tumoural effects. This review summaris
Literature ReviewMechanisms Review
MHID-5708535PMID: 373757652023Pharmaceuticals
Dmitri Atiakshin, Andrey Kostin, Artem Volodkin, Anna Nazarova, Viktoriya Shishkina, Dmitry Esaulenko, et al.
Knowledge of the biological effects of molecular hydrogen (H2), hydrogen gas, is con- stantly advancing, giving a reason for the optimism in several healthcare practitioners regarding the management of multiple diseases, including socially significant ones (malignant neoplasms, diabetes mellitus, viral hepatitis, mental and behavioral disorders). However, mechanisms underlying the biological effect
Animal StudyIn VitroHighlighted
MHID-1279019PMID: 372155682023Theranostics
Geru Tao, Feng Liu, Zhaokui Jin, Boyan Liu, Hao Wang, Daosheng Li, et al.
Background: Chronic liver diseases (CLD) frequently derive from hepatic steatosis, inflammation and fibrosis, and become a leading inducement of cirrhosis and hepatocarcinoma. Molecular hydrogen (H2) is an emerging wide-spectrum anti-inflammatory molecule which is able to improve hepatic inflammation and metabolic dysfunction, and holds obvious advantages in biosafety over traditional anti-CLD dru
Clinical TrialHighlighted
MHID-1277179PMID: 373719712023Antioxidants
Md. Habibur Rahman, Johny Bajgai, Subham Sharma, Eun-Sook Jeong, Seong Hoon Goh, Yeon-Gyu Jang, et al.
Molecular hydrogen (H2) is a versatile therapeutic agent. H2 gas inhalation is reportedly safe and has a positive impact on a range of illnesses, including Alzheimer’s disease (AD). Herein, we investigated the effects of 4 weeks of H2 gas inhalation on community-dwelling adults of various ages. Fifty-four participants, including those who dropped out (5%), were screened and enrolled. The selected
Clinical TrialHighlighted
MHID-8082099PMID: 362047842023Medical Gas Research
Anna Vaycheslavovna Deryugina, Darya Andreevna Danilova, Yurii Dmitrievich Brichkin, Evgenii Vladimirovich Taranov, Evgenii Ivanovich Nazarov, Vladimir Viktorovich Pichugin, et al.
Molecular hydrogen (H2) has been considered a preventive and therapeutic medical gas in numerous diseases. The study aimed to investigate the potential role of molecular hydrogen as a component of anesthesia in surgical treatment with cardiopulmonary bypass (CPB) of acquired valve defects on the functional state of red blood cells (RBC) and functional indicators of cardiac activity. This clinical
Animal StudyChemical/Physicochemical StudyHighlighted
MHID-2226442PMID: 374635172023Canadian Journal of Physiology and Pharmacology
Barbora Kalocayova, Branislav Kura, Jana Vlkovicova, Denisa Snurikova, Norbert Vrbjar, Karel Frimmel, et al.
Cardiac surgery-associated acute kidney injury (CS-AKI) is a common postoperative complication, mostly due to increasing oxidative stress. Recently, molecular hydrogen (H2 gas), has also been applied to cardiac surgery due to its ability to reduce oxidative stress. We evaluated the potential effect of H2 application on the kidney in an in vivo model of simulated heart transplantation. Pigs underwe
Clinical TrialHighlighted
MHID-6311122PMID: 369693462023eClinicalMedicine
Tomoyoshi Tamura, Masaru Suzuki, Koichiro Homma, Motoaki Sano
Background Inhaled molecular hydrogen gas (H2) has been shown to improve outcomes in animal models of cardiac arrest (CA). H2 inhalation is safe and feasible in patients after CA. We investigated whether inhaled H2 would improve outcomes after out-of-hospital CA (OHCA).
Methods HYBRID II is a prospective, multicentre, randomised, double-blind, placebo-controlled trial performed at 15 hospitals in
