Literature ReviewMechanisms Review
MHID-5708535PMID: 373757652023Pharmaceuticals
Dmitri Atiakshin, Andrey Kostin, Artem Volodkin, Anna Nazarova, Viktoriya Shishkina, Dmitry Esaulenko, et al.
Knowledge of the biological effects of molecular hydrogen (H2), hydrogen gas, is con- stantly advancing, giving a reason for the optimism in several healthcare practitioners regarding the management of multiple diseases, including socially significant ones (malignant neoplasms, diabetes mellitus, viral hepatitis, mental and behavioral disorders). However, mechanisms underlying the biological effect
Animal StudyHighlighted
MHID-6941053PMID: 378959072023Pharmaceuticals
Seyedeh Elnaz Nazari, Alex Tarnava, Nima Khalili-Tanha, Mahdieh Darroudi, Ghazaleh Khalili-Tanha, Amir Avan, et al.
Skeletal muscle atrophy is associated with poor quality of life and disability. Thus, finding a new strategy for the prevention and treatment of skeletal muscle atrophy is very crucial. This study aimed to investigate the therapeutic potential of hydrogen-rich water (HRW) on muscle atrophy in a unilateral hind limb immobilization model. Thirty-six male Balb/C mice were divided into control (without
Clinical TrialObservational StudyHighlighted
MHID-7657388PMID: 378737712023Diseases
Ram B. Singh, Alex Tarnava, Ghizal Fatima, Jan Fedacko, Viliam Mojto, Tyler W. LeBaron
Background: Recently, chronic lung diseases have been found to be associated with marked inflammation and oxidative stress, which leads to fibrosis in the lungs and chronic respiratory failure. This study aims to determine if hydrogen-rich water (HRW) can enhance oxygen saturation among patients with chronic lung diseases. Methods: Ten patients with chronic lung diseases due to COPD (n = 7), bronchi
Animal StudyHighlighted
MHID-0513892PMID: 351161142022World Journal of Gastrointestinal Oncology
Fereshteh Asgharzadeh, Alex Tarnava, Asma Mostafapour, Majid Khazaei, Tyler W. LeBaron
Background: Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in the world. Tumor removal remains the preferred frontline treatment; however, effective non-surgical interventions remain a high priority. 5-fluorouracil (5-FU) is a widely used chemotherapy agent, and molecular hydrogen (H2) has been re- cognized for its antioxidant and anti-inflammatory effects, with resear
Clinical TrialHighlighted
MHID-82748422022Processes
Mihyun Lee, Ailyn Fadriquela, Jayson M. Antonio, Cheol-Su Kim, Il-Young Cho, Ka-Eun Kim, et al.
Regular physical activity confers health benefits and improves the general quality of life. Recently, alkaline-reduced water (ARW) consumption has garnered increasing attention in the field of sports. ARW effectively inhibits the oxidative stress generated in cells during high-intensity exercises; however, whether it exerts similar effects during exhaustive exercises remains unknown. This study was
Observational StudyHighlighted
MHID-5864798PMID: 347652122021Clinical Case Reports
Ram B. Singh, Ghazi Halabi, Ghizal Fatima, Richa H. Rai, Alexander T. Tarnava, Tyler W. LeBaron
Administration of molecular hydrogen dissolved in water to patient with COVID-19-like symptoms may improve oxygen levels and exercise capacity.
Observational StudyHighlighted
MHID-6285582PMID: 346451002021Journal of Integrative Neuroscience
Tyler W. LeBaron, Jason Kharman, Michael L. McCullough
Traumatic brain injuries (TBIs) are a leading cause of death and dis- ability. Sports-related TBIs are estimated to be more than several million per year. The pathophysiology of TBIs involves high levels of inflammation, oxidative stress, dysregulation of ion homeosta- sis, mitochondrial dysfunction, and apoptosis. There is also a reduc- tion in cerebral blood flow, leading to hypoxia and reduced
Literature Review
MHID-9272690PMID: 330783742021Neuroscience Bulletin
Wei Chen, Han-Ting Zhang, Shu-Cun Qin
Molecular hydrogen (H2) is a physiologically inert gas. However, during the last 10 years, increasing evidence has revealed its biological functions under pathological conditions. More specifically, H2 has protec- tive effects against a variety of diseases, particularly nervous system disorders, which include ischemia/reperfu- sion injury, traumatic injury, subarachnoid hemorrhage, neuropathic pain
Literature Review
MHID-6029476PMID: 346464232021Oxidative Medicine and Cellular Longevity
Duried Alwazeer, Franky Fuh-Ching Liu, Xiao Yu Wu, Tyler W. LeBaron
COVID-19 is a widespread global pandemic with nearly 185 million confirmed cases and about four million deaths. It is caused by an infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which primarily affects the alveolar type II pneumocytes. The infection induces pathological responses including increased inflammation, oxidative stress, and apoptosis. This situation result
Literature Review
MHID-5326803PMID: 349874192021Frontiers in Physiology
Yan Tian, Yafang Zhang, Yu Wang, Yunxi Chen, Weiping Fan, Jianjun Zhou, et al.
Molecular hydrogen (H2) is a colorless and odorless gas. Studies have shown that H2 inhalation has the therapeutic effects in many animal studies and clinical trials, and its application is recommended in the novel coronavirus pneumonia treatment guidelines in China recently. H2 has a relatively small molecular mass, which helps it quickly spread and penetrate cell membranes to exert a wide range
Systematic ReviewHighlighted
MHID-30922442021Journal of Syiah Kuala Dentistry Society
Albert Manggading Hutapea, Lina Hadi
Diabetes Mellitus (DM) is a metabolic disorder characterized by high blood glucose levels associated with periodontal disease and increased levels of inflammatory biomarkers such as interleukin. Therapeutic effects of molecular hydrogen for a wide range of disease models and human diseases have been investigated. This review aims to systematically analyze and review animal and human studies invest
Literature ReviewMeta-Analysis
MHID-7985788PMID: 328266282020Current Opinion in Anesthesiology
Zhen Wang, Guolin Wang, Keliang Xie
Purpose of review: The current systematic review summarizes recent, basic clinical achievements regarding the neuroprotective effects of molecular hydrogen in distinct central nervous system conditions.
Recent findings: Perioperative neuroprotection remains a major topic of clinical anesthesia. Various gaseous molecules have previously been explored as a feasible therapeutic option in neurologica
Literature Review
MHID-9675573PMID: 320157862020Oxidative Medicine and Cellular Longevity
Takuji Kawamura, Kazuhiko Higashida, Isao Muraoka
Molecular hydrogen (H2) is a colorless, tasteless, odorless, and minimal molecule with high flammability. Although H2 has been thought to be an inert gas in living bodies for many years, an animal study reported that inhalation of H2 gas decreased oxidative stress and suppressed brain injury caused by ischemia and reperfusion injury due to its antioxidant action. Since then, the antioxidant action
Clinical Trial
MHID-9025289PMID: 326992872020Scientific Reports
Minju Sim, Chong‑Su Kim, Woo‑Jeong Shon, Young‑Kwan Lee, Eun Young Choi, Dong‑Mi Shin
The evidence for the beneficial effects of drinking hydrogen-water (HW) is rare. We aimed to investigate the effects of HW consumption on oxidative stress and immune functions in healthy adults using systemic approaches of biochemical, cellular, and molecular nutrition. In a randomized, double-blind, placebo-controlled study, healthy adults (20–59 y) consumed either 1.5 L/d of HW (n = 20) or plain
Literature Review
MHID-3461972PMID: 309702152019Canadian Journal of Physiology and Pharmacology
Tyler W. LeBaron, Ismail Laher, Branislav Kura, Jan Slezak
H2 has been clinically demonstrated to provide antioxidant and anti-inflammatory effects, which makes it an attractive agent in exercise medicine. Although exercise provides a multiplicity of benefits including decreased risk of disease, it can also have detrimental effects. For example, chronic high-intensity exercise in elite athletes, or sporadic bouts of exercise (i.e. noxious exercise) in unt
Clinical Trial
MHID-2512221PMID: 315745442019International Journal of Sports Medicine
Michal Botek, Jakub Krejčí, Andrew J. McKune, Barbora Sládečková, Nenad Naumovski
The potential anti-fatigue and performance benefits of hydrogen rich water (HRW) have resulted in increased research interest over the past 5 years. The aim of this study was to assess physiological and perceptual responses to an incremental exercise protocol after administration of 600 ml HRW within 30 min before exercise. This randomized, double blinded placebo-controlled cross over study includ
Observational StudyHighlighted
MHID-9389875PMID: 325959372019F1000Research
Dejan Javorac, Valdemar Stajer, Sergej M Ostojic
Sport-related mild traumatic brain injury (TBI) is a serious
Background:
trauma that could impair brain function of an injured athlete. Treatment
solutions for mild TBI typically concentrate on complete rest, while
non-traditional therapeutic options remain largely ineffective. Molecular
hydrogen (H ) is an innovative neuroprotective agent that can easily reach
the brain, yet no data are available
Literature Review
MHID-1011283PMID: 312232852019International Journal of Biological Sciences
Peng Qiu, Yang Liu, Jin Zhang
Sepsis is a syndrome comprised of a series of life-threatening organ dysfunctions caused by a maladjusted body response to infection with no effective treatment. Molecular hydrogen is a new type of antioxidant with strong free radical scavenging ability, which has been demonstrated to be effective for treating various diseases, such as infection, trauma, poisoning, organ ischemia-reperfusion, meta
Animal StudyHighlighted
MHID-6575678PMID: 298504922018BioMed Research International
Jesmin Ara, Ailyn Fadriquela, Md Faruk Ahmed, Johny Bajgai, Ma Easter Joy Sajo, Sung Pyo Lee, et al.
Purpose. This study was performed to evaluate antifatigue effect of hydrogen water (HW) drinking in chronic forced exercise mice model.
Materials and Methods. Twelve-week-old C57BL6 female mice were divided into nonstressed normal control (NC) group and stressed group: (purified water/PW-treated group and HW-treated group). Stressed groups were supplied with PW and HW, respectively, ad libitum an
Literature Review
MHID-31863052018Asia-Pacific Journal of Blood Types and Genes
Jinqi Li, Yan Zang, Haihui Gu, Baohua Qian
Hydrogen (H2) is a colorless, odorless gas that can act as a reducing agent under certain circumstances. Previously considered physiologically an inert and nonfunctional molecule in mammalian cells, H2 largely went ignored until Nature Medicine revealed the antioxidant and cytoprotective effects of hydrogen gas in a focal stroke model. Reactive oxygen species (ROS) is generated inside the body thr
