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Literature ReviewHighlighted

A comprehensive review of molecular hydrogen as a novel nutrition therapy in relieving oxidative stress and diseases: Mechanisms and perspectives

MHID-0845802PMID: 399115282025Biochemistry and Biophysics Reports

Fatmanur Yıldız, Tyler W. LeBaron, Duried Alwazeer

Oxidative stress is responsible for the pathogenesis of many diseases, and antioxidants are commonly included in their treatment protocols. Over the past two decades, numerous biomedical reports have revealed the therapeutic benefits of molecular hydrogen (H2) in relieving oxidation-related diseases. H2 has been found to have selective antioxidant properties against the most dangerous oxidants (hy

Literature Review

New Possibilities of the Prevention and Treatment of Cardiovascular Pathologies. The Potential of Molecular Hydrogen in the Reduction of Oxidative Stress and its Consequences

MHID-5103861PMID: 398081702024Physiological Research

Jan Slezak, Tatiana Ravingerova, Branislav Kura

Disproportion between reactive oxygen species (ROS) production and the body's antioxidant system can cause oxidative stress, which is considered a common denominator in various pathological conditions, including cardiovascular diseases, aging, and cognitive disorders. The generation of free radicals, which occurs through partial reduction of oxygen, can quickly overwhelm the endogenous antioxidant

Literature Review

The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance

MHID-0878205PMID: 236800322013Medical Gas Research

Brandon J Dixon, Jiping Tang, John H Zhang

Studies on molecular hydrogen have evolved tremendously from its humble beginnings and have continued to change throughout the years. Hydrogen is extremely unique since it has the capability to act at the cellular level. Hydrogen is qualified to cross the blood brain barrier, to enter the mitochondria, and even has the ability to translocate to the nucleus under certain conditions. Once in these i

Literature Review

Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases

MHID-8352354PMID: 216215882012Biochimica et Biophysica Acta

Shigeo Ohta

Background: Mitochondria are the major source of oxidative stress. Acute oxidative stress causes serious damage to tissues, and persistent oxidative stress is one of the causes of many common diseases, cancer and the aging process; however, there has been little success in developing an effective antioxidant with no side effect. We have reported that molecular hydrogen has potential as an effectiv

Human StudyLiterature ReviewAnimal StudyIn VitroHighlighted

The 2011 Medical Molecular Hydrogen Symposium: An inaugural symposium of the journal Medical Gas Research

MHID-1756030PMID: 221460822011Medical Gas Research

Shigeo Ohta, Atsunori Nakao, Kinji Ohno

This report summarizes a brief description/history of the Hydrogen Research Meetings as well as key presentations/oral abstracts delivered in the most recent symposium. Additionally, we introduced 38 diseases and physiological states for which hydrogen exhibits beneficial effects.