Animal StudyHighlighted
MHID-8093676PMID: 401048812025Veterinary Medicine and Science
Buket Boğa Kuru, Mustafa Makav, Mushap Kuru, Şükran Yediel Aras, Ebru Karadağ Sarı, Menekşe Bulut, et al.
Objectives: This study investigated the impact of drinking hydrogen-rich water (HRW) on growth performance, organ weights, thiol/disulphide homeostasis, oxidative status and some hormonal, histopathological and immunohistochemical changes in rats fed in a restricted housing environment.
Methods: The eight groups (each group [male/female] eight rats) comprised two control, two hydrogen, two stress
Clinical TrialHighlighted
MHID-5491717PMID: 412043202025Trials
Victoria Habet, Tysen DeWaard, Krislyn M. Boggs, Alix Fetch, Bao Nguyen Puente, Lynn A. Sleeper, et al.
Background: Extracorporeal cardiopulmonary resuscitation (ECPR) improves survival for patients experiencing refractory cardiac arrest but is often associated with severe ischemia-reperfusion injury (IRI). Hydrogen gas (H2) has demonstrated promising preclinical efficacy in reducing IRI. The Hydrogen-FAST trial investigates the feasibility and safety of inhaled hydrogen gas as an adjunctive therapy
Animal StudyHighlighted
MHID-6800574PMID: 414626182025Antioxidants
Anna Vyacheslavovna Deryugina, Darya Andreevna Danilova, Anastasia Vladimirovna Polozova
Oxidative stress is a key factor in the development of chronic heart failure (CHF). Molecular hydrogen (H2) exhibits antioxidant properties, yet the mechanisms by which it alleviates hemodynamic disturbances and ischemic myocardial injury in CHF are not fully under- stood. This study examined the effects of a single (40-min) and multiple (40-min daily for 5 days) inhalations of H2 in a rat model o
Animal StudyHighlighted
MHID-5014710PMID: 407174652025British Journal of Pharmacology
Shuqi Meng, Jianfeng Liu, Yanhua Luo, Yan Fan, Zhiwei Wang, Yu Song, et al.
Background and Purpose: Sepsis-induced cardiomyopathy (SIC) is the primary cause of mortality among people with sepsis. Hydrogen (H2) has a cardioprotective effect in SIC; however, its specific mechanism remains unclear. We thus explored whether 2% H2 treatment mitigates SIC through inhibiting Golgi stress and investigated the specific molecular pathways underlying this protective effect.
Experime
Literature ReviewHighlighted
MHID-2922681PMID: 413737252025International Journal of Molecular Sciences
Daria Kornieieva, Barbora Kalocayova, Jan Slezak, Branislav Kura
Heart failure (HF) is increasing in prevalence in many countries around the world. HF is a complex clinical syndrome characterized by the heart’s inability to pump blood effectively, resulting in significant morbidity and mortality. After an initial cardiac event (e.g., myocardial infarction, valve dysfunction, hypertension, etc.), adaptive mechanisms are activated to preserve cardiac function. Su
Animal StudyHighlighted
MHID-5834617PMID: 398578172025Biomedicines
Masaki Shibuya, Masafumi Fujinaka, Mako Yonezawa, Natsumi Nishimura, Hitoshi Uchinoumi, Hiroshi Sunahara, et al.
Background: Hydrogen gas (H2) has been shown to be effective in the treatment of various clinical conditions, from acute illnesses to chronic illnesses. However, its clinical indications and the corresponding appropriate hydrogen delivery methods have yet to be determined. This is due to the fact that the pharmacokinetics and pharmacodynamics of hydrogen in each delivery method have not been exper
Clinical TrialHighlighted
MHID-1036598PMID: 399231332025Medical Gas Research
Pavel Grepl, Michal Botek, Jakub Krejčí, Andrew McKune
Initially, molecular hydrogen was considered a physiologically inert and non-functional gas. However, experimental and clinical studies have shown that molecular hydrogen has anti-inflammatory, anti-apoptotic, and strong selective antioxidant effects. This study aimed to evaluate the effects of 60 minutes of molecular hydrogen inhalation on respiratory gas analysis parameters using a randomized, d
Literature ReviewHighlighted
MHID-0845802PMID: 399115282025Biochemistry and Biophysics Reports
Fatmanur Yıldız, Tyler W. LeBaron, Duried Alwazeer
Oxidative stress is responsible for the pathogenesis of many diseases, and antioxidants are commonly included in their treatment protocols. Over the past two decades, numerous biomedical reports have revealed the therapeutic benefits of molecular hydrogen (H2) in relieving oxidation-related diseases. H2 has been found to have selective antioxidant properties against the most dangerous oxidants (hy
Literature ReviewHighlighted
MHID-44233202024Molecular Hydrogen in Health and Disease, Advances in Biochemistry in Health and Disease
Shin-ichi Hirano, Yusuke Ichikawa, Bunpei Sato, Yoshiyasu Takefuji, Xiao-Kang Li, Fumitake Satoh
Mitochondria originated from aerobic bacteria in endosymbiosis. Through this symbiosis, eukaryotes acquired an efficient energy-producing system, but at the cost of exposure to oxidative stress from reactive oxygen species (ROS). Molecular hydrogen (H2) was recently identified as an antioxidant that selectively reduces ROS, such as hydroxyl radicals and peroxynitrite, which are strong oxidants, and
Literature ReviewHighlighted
MHID-1339888PMID: 397659102024Antioxidants
Mikhail Yu. Artamonov, Felix A. Pyatakovich, Inessa A. Minenko
In regenerative medicine, mesenchymal stem cells (MSCs) have shown their importance and potential in tissue reconstruction and immune system modification. However, such cells’ potential is often diminished by factors such as oxidative stress, immune rejection, and inadequate engraftment. This review highlights the role of molecular hydrogen (H2) and cold atmospheric plasma (CAP) as adjunct therapi
Clinical Trial
MHID-7502024PMID: 414014412024Canadian Journal of Physiology and Pharmacology
Pavel Grepl, Jakub Krejčí, Andrew McKune, Michal Botek
Molecular hydrogen has gained attention for its potential antioxidant, anti-inflammatory, and ergogenic effects. However, its impact on blood oxygen saturation and autonomic cardiac regulation under resting conditions remains unclear. This randomized, double-blind, placebo-controlled crossover study investigated the effects of a 60-minute molecular hydrogen inhalation on oxygen saturation and hear
Animal Study
MHID-5679511PMID: 383958002024BMC Anesthesiology
Yan Cui, Yingning Li, Shuqi Meng, Yu Song, Keliang Xie
Background: Approximately 40 to 60% of patients with sepsis develop sepsis-induced cardiomyopathy (SIC), which is associated with a substantial increase in mortality. We have found that molecular hydrogen (H2) inhalation improved the survival rate and cardiac injury in septic mice. However, the mechanism remains unclear. This study aimed to explore the regulatory mechanism by which hydrogen modula
Animal StudyHighlighted
MHID-13886872024Journal of Evolutionary Biochemistry and Physiology
M. M. Artemieva, T. A. Kuropatkina, V. V. Shishkina, D. V. Serebryanaya, D. A. Adasheva, O. S. Medvedev, et al.
Molecular hydrogen demonstrates antioxidant and anti-inflammatory properties. It has been
shown to have a protective effect in several cardiovascular diseases. The aim of this work was to
investigate the effect of breathing atmospheric air containing 4% hydrogen on the degree of development
of monocrotaline-induced pulmonary hypertension and associated lung tissue inflammation, as well as
the degr
Literature Review
MHID-6342582PMID: 390776462024Reviews in Cardiovascular Medicine
Ram B. Singh, Zuzana Sumbalova, Ghizal Fatima, Viliam Mojto, Jan Fedacko, Alex Tarnava, et al.
Diet and lifestyle choices, notably the Western-type diet, are implicated in oxidative stress and inflammation, factors that elevate the risk of cardiovascular diseases (CVDs) and type 2 diabetes mellitus (T2DM). In contrast, the Mediterranean of diet, rich in antioxidants, appears to have protective effects against these risks. This article highlights the dual role of diet in generating molecular
Animal StudyHighlighted
MHID-3732487PMID: 390635512024Life
Wen-Ling Shih, Tsung-Ming Yeh, Kuang-Den Chen, Steve Leu, Shih-Feng Liu, Ying-Hsien Huang, et al.
Background: Kawasaki disease (KD) is a syndrome primarily affecting young children, typically under the age of five, and is characterized by the development of acute vasculitis. Through extensive research conducted on both murine and human subjects, it has been demonstrated that heightened levels of reactive oxygen species (ROS) play a pivotal role in the development of KD, especial coronary arter
Literature Review
MHID-5103861PMID: 398081702024Physiological Research
Jan Slezak, Tatiana Ravingerova, Branislav Kura
Disproportion between reactive oxygen species (ROS) production and the body's antioxidant system can cause oxidative stress, which is considered a common denominator in various pathological conditions, including cardiovascular diseases, aging, and cognitive disorders. The generation of free radicals, which occurs through partial reduction of oxygen, can quickly overwhelm the endogenous antioxidant
Human StudyLiterature ReviewAnimal Study
MHID-3562676PMID: 372693852023Cellular and Molecular Life Sciences
Kwannapas Saengsin, Rekwan Sittiwangkul, Siriporn C. Chattipakorn, Nipon Chattipakorn
Cardiovascular disease is the leading cause of mortality worldwide. Excessive oxidative stress and inflammation play an important role in the development and progression of cardiovascular disease. Molecular hydrogen, a small colorless and odorless molecule, is considered harmless in daily life when its concentration is below 4% at room temperature. Owing to the small size of the hydrogen molecule,
Animal StudyHighlighted
MHID-2957577PMID: 381373622023Biomedicines
Tatyana Kuropatkina, Dmitrii Atiakshin, Fedor Sychev, Marina Artemieva, Tatyana Samoilenko, Olga Gerasimova, et al.
Hydrogen has been shown to exhibit selective antioxidant properties against hydroxyl radicals, and exerts antioxidant and anti-inflammatory effects. The monocrotaline-induced model of pulmonary hypertension is suitable for studying substances with antioxidant activity because oxidative stress is induced by monocrotaline.
On day 1, male Wistar rats were subcutaneously injected with a water–alcohol
Literature ReviewHighlighted
MHID-6539221PMID: 372378542023Antioxidants
Md. Habibur Rahman, Eun-Sook Jeong, Hae Sun You, Cheol-Su Kim, Kyu-Jae Lee
Age-related diseases represent the largest threat to public health. Aging is a degenerative, systemic, multifactorial and progressive process, coupled with progressive loss of function and eventually leading to high mortality rates. Excessive levels of both pro- and anti-oxidant species qualify as oxidative stress (OS) and result in damage to molecules and cells. OS plays a crucial role in the dev
Clinical TrialHighlighted
MHID-8082099PMID: 362047842023Medical Gas Research
Anna Vaycheslavovna Deryugina, Darya Andreevna Danilova, Yurii Dmitrievich Brichkin, Evgenii Vladimirovich Taranov, Evgenii Ivanovich Nazarov, Vladimir Viktorovich Pichugin, et al.
Molecular hydrogen (H2) has been considered a preventive and therapeutic medical gas in numerous diseases. The study aimed to investigate the potential role of molecular hydrogen as a component of anesthesia in surgical treatment with cardiopulmonary bypass (CPB) of acquired valve defects on the functional state of red blood cells (RBC) and functional indicators of cardiac activity. This clinical
