Observational StudyHighlighted
MHID-16201432021Renal Replacement Therapy
Yoshihiro Tsujimoto, Daisuke Kuratsune, Shigeru Kabayama, Mariko Miyazaki, Yasuyoshi Watanabe, Yoshiki Nishizawa, et al.
Background: Enhanced oxidative stress is involved with fatigue in hemodialysis (HD) patients. Molecular hydrogen (H2) could improve the redox status. Thus, the study examines whether HD solution rendered by electrolyzed water containing H2 (E-HD) could impact the fatigue and autonomic balance of patients.
Methods: This single-arm, prospective observational study examined 95 patients on chronic HD
Animal Study
MHID-1878579PMID: 322460952020Scientific Reports
Yuki Kobayashi, Ryoichi Imamura, Yoshihisa Koyama, Makoto Kondo, Hikaru Kobayashi, Norio Nonomura, et al.
We have developed Si-based agent which can generate a large amount of hydrogen. Si-based agent continues generating hydrogen for more than 24 h by the reaction with water under conditions similar to those in bowels, i.e., pH8.3 and 36 °C, and generates ~400 mL hydrogen. To investigate beneficial effects for diseases associated with oxidative stress, Si-based agent is administered to remnant kidney
Observational Study
MHID-8360107PMID: 293215092018Scientific Reports
Masaaki Nakayama, Noritomo Itami, Hodaka Suzuki, Hiromi Hamada, Ryo Yamamoto, Kazumasa Tsunoda, et al.
Recent studies have revealed unique biological characteristics of molecular hydrogen (H2) as an anti-inflammatory agent. We developed a novel haemodialysis (E-HD) system delivering an H2 (30–80 ppb)-enriched dialysis solution by water electrolysis, and conducted a non-randomized, non-blinded, prospective observational study exploring its clinical impact. Prevalent chronic HD patients were allocate
Animal Study
MHID-5925679PMID: 290890292017BMC Nephrology
Masaaki Nakayama, Wan-Jun Zhu, Kimio Watanabe, Ayano Gibo, Ali M. Sherif, Shigeru Kabayama, et al.
Background: Peritoneal dialysis (PD) is used as renal replacement therapy in patients with end-stage kidney disease. However, peritoneal membrane failure remains problematic and constitutes a critical cause of PD discontinuation. Recent studies have revealed the unique biological action of molecular hydrogen (H2) as an antioxidant, which ameliorates tissue injury. In the present study, we aimed to
Observational StudyHighlighted
MHID-9655362PMID: 289029002017PLoS ONE
Masaaki Nakayama, Noritomo Itami, Hodaka Suzuki, Hiromi Hamada, Naoyuki Osaka, Ryo Yamamoto, et al.
Background and aim: It is supposed that enhanced oxidative stress and inflammation are involved with the poor clinical outcomes in patients on chronic dialysis treatment. Recent studies have shown that molecular hydrogen (H2) is biologically active as an anti-inflammatory agent. Thus, we developed a novel hemodialysis (E-HD) system which delivers H2 (30 to 80 ppb)-enriched dialysis solution, to co
Animal StudyHighlighted
MHID-3260346PMID: 288484322017Frontiers in Pharmacology
Jing Chen, Han Zhang, Jiachang Hu, Yulu Gu, Ziyan Shen, Linghan Xu, et al.
Purpose: Acute kidney injury (AKI) is a prominent risk factor for the development of chronic kidney disease (CKD). To date, the related mechanism and effective therapy have not been rigorously explored. The present study aims to investigate the reno- protection of hydrogen-rich saline (HRS) against ischemia/reperfusion (IR)-induced AKI.
Methods: Adult male C57 mice were randomly allocated into th
Literature ReviewHighlighted
MHID-2847992PMID: 278264242016Medical Gas Research
Ou-yang Chen, Zhou-heng Ye, Chong Li
June 27, 2015, the Second Hydrogen Molecule Biomedical Symposium and the Second meeting of the Professional Committee of Molecular Hydrogen Biology and Medicine of China Association of Promoting International Communication of health care was grand opening in the Capital of China, Beijing, sponsored by China Association of Promoting International Communication of health care, undertaken by Professi
Animal StudyHighlighted
MHID-7644453PMID: 277741162016Oxidative Medicine and Cellular Longevity
Jiaming Guo, Deyun Zhao, Xiao Lei, Hainan Zhao, Yanyong Yang, Pei Zhang, et al.
Molecular hydrogen (H2) has been previously reported playing an important role in ameliorating damage caused by acute radiation. In this study, we investigated the effects of H2 on the alterations induced by low-dose long-term radiation (LDLTR). All the mice in hydrogen-treated or radiation-only groups received 0.1 Gy, 0.5 Gy, 1.0 Gy, and 2.0 Gy whole-body gamma radiation, respectively. After the
Animal StudyIn VitroHighlighted
MHID-8667127PMID: 277892932016Free Radical Biology and Medicine
Takafumi Ushida, Tomomi Kotani, Hiroyuki Tsuda, Kenji Imai, Tomoko Nakano, Shima Hirako, et al.
Oxidative stress plays an important role in the pathogenesis of preeclampsia. Recently, molecular hydrogen (H2) has been shown to have therapeutic potential in various oxidative stress-related diseases. The aim of this study is to investigate the effect of H2 on preeclampsia. We used the reduced utero-placental perfusion pressure (RUPP) rat model, which has been widely used as a model of preeclamps
Literature Review
MHID-0365812PMID: 282172942016Medical Gas Research
Lei Huang
Molecular hydrogen (H2) medicine research has flourished since a landmark publication in Nature Medicine that revealed the antioxidant and cytoprotective effects of hydrogen gas in a focal stroke model. Emerging evidence has consistently demonstrated that molecular hydrogen is a promising therapeutic option for a variety of diseases and the underlying comprehensive mechanisms is beyond pure hydrox
Literature ReviewHighlighted
MHID-7479916PMID: 264839532015Medical Gas Research
Masatoshi Ichihara, Sayaka Sobue, Mikako Ito, Masafumi Ito, Masaaki Hirayama, Kinji Ohno
Therapeutic effects of molecular hydrogen for a wide range of disease models and human diseases have been investigated since 2007. A total of 321 original articles have been published from 2007 to June 2015. Most studies have been conducted in Japan, China, and the USA. About three-quarters of the articles show the effects in mice and rats. The number of clinical trials is increasing every year. I
Animal StudyHighlighted
MHID-4748086PMID: 260479402015Journal of Translational Medicine
Song‑Xue Guo, Quan Fang, Chuan‑Gang You, Yun‑Yun Jin, Xin‑Gang Wang, Xin‑Lei Hu, et al.
Background: Early acute kidney injury (AKI) in severely burned patients predicts a high mortality that is multi-factorial. Hydrogen has been reported to alleviate organ injury via selective quenching of reactive oxygen species. This study investigated the potential protective effects of hydrogen against severe burn-induced early AKI in rats.
Methods: Severe burn were induced via immersing the sha
Literature ReviewHighlighted
MHID-2487803PMID: 306788962013International Journal of Biological Sciences
Liren Qian, Jianliang Shen, Yunhai Chuai, Jianming Cai
It is well known that most of the ionizing radiation-induced damage is caused by hydroxyl radicals (·OH) follows radiolysis of H2O. Molecular hydrogen (H2) has antioxidant activities by selectively reducing ·OH and peroxynitrite(ONOO-). We firstly hypothesized and demonstrated the ra-dioprotective effect of H2 in vitro and in vivo, which was also repeated on different experimental animal models by
Animal StudyHighlighted
MHID-57013782012Medical Science Monitor
Yunhai Chuai, Jianliang Shen, Liren Qian, Yicun Wang, Yuecheng Huang, Fu Gao, et al.
Background: Recent studies show that molecular hydrogen (dihydrogen, H2) has potential as an effective and safe radioprotective agent through reducing oxidative stress. The aim of this study was to investigate whether H2 is able to protect spermatogenesis and hematopoiesis from radiation-induced injuries.
Material/Methods: H2 was dissolved in physiological saline using an apparatus produced by ou
Literature Review
MHID-5039793PMID: 227201172012Oxidative Medicine and Cellular Longevity
Kinji Ohno, Mikako Ito, Masatoshi Ichihara, Masafumi Ito
Effects of molecular hydrogen on various diseases have been documented for 63 disease models and human diseases in the past four and a half years. Most studies have been performed on rodents including two models of Parkinson’s disease and three models of Alzheimer’s disease. Prominent effects are observed especially in oxidative stress-mediated diseases including neonatal cerebral hypoxia; Parkinson
Animal StudyIn VitroHighlighted
MHID-7164222PMID: 227767732012Medical Gas Research
Masanori Katakura, Michio Hashimoto, Yoko Tanabe, Osamu Shido
Background: Reactive oxygen species (ROS) production induced by α,β-dicarbonyl compounds and advanced glycation end products causes renal dysfunction in patients with type 2 diabetes and metabolic syndrome. Hydrogen-rich water (HRW) increases the H2 level in blood and tissues, thus reducing oxidative stress in animals as well as humans. In this study, we investigated the effects of HRW on glucose-
Human StudyLiterature ReviewAnimal StudyIn VitroHighlighted
MHID-1756030PMID: 221460822011Medical Gas Research
Shigeo Ohta, Atsunori Nakao, Kinji Ohno
This report summarizes a brief description/history of the Hydrogen Research Meetings as well as key presentations/oral abstracts delivered in the most recent symposium. Additionally, we introduced 38 diseases and physiological states for which hydrogen exhibits beneficial effects.
Animal StudyHighlighted
MHID-2760312PMID: 221460832011Medical Gas Research
Michio Hashimoto, Masanori Katakura, Toru Nabika, Yoko Tanabe, Shahdat Hossain, Satoru Tsuchikura, et al.
Background: Hydrogen (H2), a potent free radical scavenger, selectively reduces the hydroxyl radical, which is the most cytotoxic of the reactive oxygen species (ROS). An increase in oxygen free radicals induces oxidative stress, which is known to be involved in the development of metabolic syndrome. Therefore, we investigated whether hydrogen-rich water (HRW) affects metabolic abnormalities in th
Animal StudyIn VitroHighlighted
MHID-5929908PMID: 191486452009Cancer Chemotherapy and Pharmacology
Naomi Nakashima-Kamimura, Takashi Mori, Ikuroh Ohsawa, Sadamitsu Asoh, Shigeo Ohta
Purpose: Cisplatin is a widely used anti-cancer drug in the treatment of a wide range of tumors; however, its application is limited by nephrotoxicity, which is affected by oxidative stress. We have reported that molecular hydrogen (H(2)) acts as an efficient antioxidant (Ohsawa et al. in Nat Med 13:688-694, 2007). Here we show that hydrogen efficiently mitigates the side effects of cisplatin by r
