Animal StudyHighlighted
MHID-61354972014Scientific Reports
Chi Liu, Ryosuke Kurokawa, Masayuki Fujino, Shinichi Hirano, Bunpei Sato, Xiao-Kang Li
Hydrogen exerts beneficial effects in disease animal models of ischemia-reperfusion injury as well as inflammatory and neurological disease. Additionally, molecular hydrogen is useful for various novel medical and therapeutic applications in the clinical setting. In the present study, the hydrogen concentration in rat blood and tissue was estimated. Wistar rats were orally administered hydrogen su
Animal Study
MHID-1154767PMID: 249410012014PLoS ONE
Masanori Kawaguchi, Yasushi Satoh, Yukiko Otsubo, Tomiei Kazama
Neuropathic pain remains intractable and the development of new therapeutic strategies are urgently required. Accumulating evidence indicates that overproduction of oxidative stress is a key event in the pathogenesis of neuropathic pain. However, repeated intra-peritoneal or intrathecal injections of antioxidants are unsuitable for continuous use in therapy. Here we show a novel therapeutic method
Animal Study
MHID-0185761PMID: 252512202014PLoS ONE
Kenji Dohi, Brian C. Kraemer, Michelle A. Erickson, Pamela J. McMillan, Andrej Kovac, Zuzana Flachbartova, et al.
Traumatic brain injury (TBI) in its various forms has emerged as a major problem for modern society. Acute TBI can transform into a chronic condition and be a risk factor for neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases, probably through induction of oxidative stress and neuroinflammation. Here, we examined the ability of the antioxidant molecular hydrogen given in drink
Animal StudyHighlighted
MHID-9010413PMID: 240087712013Cellular Physiology and Biochemistry
Sanhu Zhao, Ke Mei, Liren Qian, Yanyong Yang, Wen Liu, Yijuan Huang, et al.
Background: Aplasitc anemia (AA) is a bone marrow failure syndrome characterized by an immune-mediated destruction of hematopoietic stem cells. Though clinical symptoms could be ameliorated by bone marrow transplantation and/or immunosuppressive therapy, frequent recurrence and especially evolution of clonal hematologic diseases remains problematic clinically. Cytokines such as interferon-γ (IFN-γ
Animal StudyHighlighted
MHID-1568601PMID: 242536162013Scientific Reports
Akio Matsumoto, Megumi Yamafuji, Tomoko Tachibana, Yusaku Nakabeppu, Mami Noda, Haruaki Nakaya
The therapeutic potential of molecular hydrogen (H2) is emerging in a number of human diseases and in their animal models, including in particular Parkinson’s disease (PD). H2 supplementation of drinking water has been shown to exert disease-modifying effects in PD patients and neuroprotective effects in experimental PD model mice. However, H2 supplementation does not result in detectable changes
Animal StudyHighlighted
MHID-1417416PMID: 234757672013American Journal of Physiology - Lung Cellular and Molecular Physiology
Tomohiro Kawamura, Nobunao Wakabayashi, Norihisa Shigemura, Chien-Sheng Huang, Kosuke Masutani, Yugo Tanaka, et al.
Hyperoxic lung injury is a major concern in critically ill patients who receive high concentrations of oxygen to treat lung diseases. Successful abrogation of hyperoxic lung injury would have a huge impact on respiratory and critical care medicine. Hydrogen can be administered as a therapeutic medical gas. We recently demonstrated that inhaled hydrogen reduced transplant-induced lung injury and in
Animal StudyHighlighted
MHID-3385882PMID: 238115542013Biological & Pharmaceutical Bulletin
Rosa Mistica Coles Ignacio, Tae-Young Kang, Cheol-Su Kim, Soo-Ki Kim, Young-Chul Yang, Joon-Hyung Sohn, et al.
Whether or not alkaline reduced water (ARW) has a positive effect on obesity is unclear. This study aims to prove the positive effect of ARW in high-fat (HF) diet-induced obesity (DIO) in C57BL/6 mice model. Toward this, obesity was induced by feeding the C57BL/6 male mice with high-fat diet (w/w 45% fat) for 12 weeks. Thereafter, the animals were administered with either ARW or tap water. Next, t
Clinical TrialAnimal StudyHighlighted
MHID-5560534PMID: 236101592013Journal of Lipid Research
Guohua Song, Min Li, Hui Sang, Liying Zhang, Xiuhong Li, Shutong Yao, et al.
We have found that hydrogen (dihydrogen; H 2 ) has benefi cial lipid-lowering effects in high-fat diet-fed Syrian golden hamsters. The objective of this study was to characterize the effects of H 2 -rich water (0.9–1.0 l/day) on the content, composition, and biological activities of serum lipoproteins on 20 patients with potential metabolic syn- drome. Serum analysis showed that consumption of H 2
Animal StudyHighlighted
MHID-5043020PMID: 236615162013European Review for Medical and Pharmacological Sciences
M. Xiao, T. Zhu, T. Wang, F.-Q. Wen
Recent studies suggest that hydrogen has great therapeutic and prophylactic potential against organ injury caused by oxidative stress and inflammation. Here we investigated the effect of hydrogen-rich saline on airway inflammation and remodeling in a murine model of asthma.
MATERIALS AND METHODS: Asthma was induced by ovalbumin (OVA) sensitization and challenge. Then mice were treated with normal
Animal StudyHighlighted
MHID-3846502PMID: 359044492013Molecular Vision
Chun-xiao Yang, Hong Yan, Tian-bing Ding
Purpose: The aim of this study was to investigate the potential antioxidative effect and mechanism for the protective effects of hydrogen saline on selenite-induced cataract in rats.
Methods: Sprague-Dawley rat pups were divided into the following groups: control (Group A), selenite induced (Group B), and selenite plus hydrogen saline treated (Group C). Rat pups in Groups B and C received a singl
Animal StudyHighlighted
MHID-57013782012Medical Science Monitor
Yunhai Chuai, Jianliang Shen, Liren Qian, Yicun Wang, Yuecheng Huang, Fu Gao, et al.
Background: Recent studies show that molecular hydrogen (dihydrogen, H2) has potential as an effective and safe radioprotective agent through reducing oxidative stress. The aim of this study was to investigate whether H2 is able to protect spermatogenesis and hematopoiesis from radiation-induced injuries.
Material/Methods: H2 was dissolved in physiological saline using an apparatus produced by ou
Animal StudyIn VitroHighlighted
MHID-89507332012Medical Science Monitor
Yanyong Yang, Bailong Li, Cong Liu, Yunhai Chuai, Jixiao Lei, Fu Gao, et al.
Background: Radiation often causes depletion of immunocytes in tissues and blood, which results in immuno suppression. Molecular hydrogen (H2) has been shown in recent studies to have potential as a safe and effective radioprotective agent through scavenging free radicals. This study was designed to test the hypothesis that H2 could protect immunocytes from ionizing radiation (IR).
Material/Metho
Animal StudyIn VitroHighlighted
MHID-7737580PMID: 231402242012Transplant International
Kentaro Noda, Yugo Tanaka, Norihisa Shigemura, Tomohiro Kawamura, Yinna Wang, Kosuke Masutani, et al.
Recent evidence suggests that molecular hydrogen has therapeutic value for dis-
ease states that involve inflammation. We hypothesized that drinking hydro-
gen-rich water (HW) daily would protect cardiac and aortic allograft recipients
from inflammation-associated deterioration. Heterotopic heart transplantation
with short-course tacrolimus immunosuppression and orthotopic aortic trans-
plantation w
Animal StudyHighlighted
MHID-09896642012Biochemical and Biophysical Research Communications
Yugo Tanaka, Norihisa Shigemura, Tomohiro Kawamura, Kentaro Noda, Kumiko Isse, Donna Beer Stolz, et al.
Background—We previously demonstrated that donor treatment with inhaled hydrogen protects lung grafts from cold ischemia/reperfusion (I/R) injury during lung transplantation. To elucidate the mechanisms underlying hydrogen’s protective effects, we conducted a gene array analysis to identify changes in gene expression associated with hydrogen treatment.
Methods—Donor rats were exposed to mechanica
Animal StudyIn VitroObservational StudyHighlighted
MHID-5280800PMID: 226080092012Medical Gas Research
Mikako Ito, Masaaki Hirayama, Kazuaki Yamai, Sae Goto, Masafumi Ito, Masatoshi Ichihara, et al.
Background: Lactulose is a synthetic disaccharide that can be catalyzed only by intestinal bacteria in humans and rodents, and a large amount of hydrogen is produced by bacterial catalysis of lactulose. We previously reported marked effects of ad libitum administration of hydrogen water on prevention of a rat model of Parkinson’s disease (PD).
Methods: End-alveolar breath hydrogen concentrations
Animal Study
MHID-20640112012Shock
Keliang Xie, Yonghao Yu, Yi Huang, Lina Zheng, Jipeng Li, Hongguang Chen, et al.
Acute lung injury (ALI) is still a leading cause of morbidity and mortality in critically ill patients. Recently, our and other studies have found that hydrogen gas (H2) treatment can ameliorate the lung injury induced by sepsis, ventilator, hyperoxia, and ischemia-reperfusion. However, the molecular mechanisms by which H2 ameliorates lung injury remain unclear. In the current study, we investigat
Animal StudyHighlighted
MHID-6057293PMID: 227620402012International Journal of Ophthalmology
Feng M, Wang XH, Yang XB, Xiao Q, Jiang FG
·AIM: To explore the effect of saturated hydrogen saline on blue light-induced retinal damage in rats.
·METHODS: The retinal damage of rats was induced by blue light exposure for 6 hours and examined 8 hours, 16 hours and 24 hours after the exposure. One hundred female Sprague-Dawley rats were randomly divided into four groups. Group 1 included 30 rats received light exposure without any other tr
Animal StudyHighlighted
MHID-2777514PMID: 225876642012BMC Neuroscience
Zong Zhuang, Meng-liang Zhou, Wan-chun You, Lin Zhu, Chi-yuan Ma, Xue-Jun Sun, et al.
Background: Increasing experimental and clinical data indicate that early brain injury (EBI) after subarachnoid hemorrhage (SAH) largely contributes to unfavorable outcomes, and it has been proved that EBI following SAH is closely associated with oxidative stress and brain edema. The present study aimed to examine the effect of hydrogen, a mild and selective cytotoxic oxygen radical scavenger, on
Animal StudyIn VitroHighlighted
MHID-7164222PMID: 227767732012Medical Gas Research
Masanori Katakura, Michio Hashimoto, Yoko Tanabe, Osamu Shido
Background: Reactive oxygen species (ROS) production induced by α,β-dicarbonyl compounds and advanced glycation end products causes renal dysfunction in patients with type 2 diabetes and metabolic syndrome. Hydrogen-rich water (HRW) increases the H2 level in blood and tissues, thus reducing oxidative stress in animals as well as humans. In this study, we investigated the effects of HRW on glucose-
Animal StudyHighlighted
MHID-2488306PMID: 220408782011Biological & Pharmaceutical Bulletin
Kyung Su YOON, Xue Zhu HUANG, Yang Suk YOON, Soo-Ki Kim, Soon Bong SONG, Byung Soo CHANG, et al.
Electrolyzed reduced water (ERW), functional water, has various beneficial effects via antioxidant mecha-
nism in vivo and in vitro. However there is no study about beneficial effects of ERW bathing. This study aimed to
determine the effect of ERW bathing on the UVB-induced skin injury in hairless mice. For this purpose, mice
were irradiated with UVB to cause skin injury, followed by individually ta
