Literature ReviewHighlighted
MHID-2487803PMID: 306788962013International Journal of Biological Sciences
Liren Qian, Jianliang Shen, Yunhai Chuai, Jianming Cai
It is well known that most of the ionizing radiation-induced damage is caused by hydroxyl radicals (·OH) follows radiolysis of H2O. Molecular hydrogen (H2) has antioxidant activities by selectively reducing ·OH and peroxynitrite(ONOO-). We firstly hypothesized and demonstrated the ra-dioprotective effect of H2 in vitro and in vivo, which was also repeated on different experimental animal models by
Animal StudyHighlighted
MHID-57013782012Medical Science Monitor
Yunhai Chuai, Jianliang Shen, Liren Qian, Yicun Wang, Yuecheng Huang, Fu Gao, et al.
Background: Recent studies show that molecular hydrogen (dihydrogen, H2) has potential as an effective and safe radioprotective agent through reducing oxidative stress. The aim of this study was to investigate whether H2 is able to protect spermatogenesis and hematopoiesis from radiation-induced injuries.
Material/Methods: H2 was dissolved in physiological saline using an apparatus produced by ou
Literature Review
MHID-5039793PMID: 227201172012Oxidative Medicine and Cellular Longevity
Kinji Ohno, Mikako Ito, Masatoshi Ichihara, Masafumi Ito
Effects of molecular hydrogen on various diseases have been documented for 63 disease models and human diseases in the past four and a half years. Most studies have been performed on rodents including two models of Parkinson’s disease and three models of Alzheimer’s disease. Prominent effects are observed especially in oxidative stress-mediated diseases including neonatal cerebral hypoxia; Parkinson
Clinical TrialHighlighted
MHID-38265332012Mayo Clinic Proceedings
Sergej M. Ostojic, MD, PhD
Metabolic acidosis is a clinical disturbance characterized by low pH in body tissues and blood and a variety of neuromuscular and cardiorespiratory responses.1 Besides treating the initial disorder, the main goal for patients with acidosis is to increase the systemic pH with alkalizing agents, such as bicarbonates2; however, adverse reactions linked to the administration of sodium bicarbonate (eg,
HypothesisHighlighted
MHID-49572952011Medical Science Monitor
Yunhai Chuai, Luqian Zhao, Jin Ni, Ding Sun, Jianguo Cui, Bailong Li, et al.
Radiotherapy is an important modality of cancer treatment. Radiation pneumonitis is a major obstacle to increasing the radiation dose in radiotherapy, and it is important to prevent this radiation-induced complication. Recent studies show that hydrogen has a potential as an effective and safe radioprotective agent by selectively reducing hydroxyl and peroxynitrite radicals. Since most of the ioniz
Human StudyLiterature ReviewAnimal StudyIn VitroHighlighted
MHID-1756030PMID: 221460822011Medical Gas Research
Shigeo Ohta, Atsunori Nakao, Kinji Ohno
This report summarizes a brief description/history of the Hydrogen Research Meetings as well as key presentations/oral abstracts delivered in the most recent symposium. Additionally, we introduced 38 diseases and physiological states for which hydrogen exhibits beneficial effects.
Clinical TrialHighlighted
MHID-4803545PMID: 221460042011Medical Gas Research
Ki-Mun Kang, Young-Nam Kang, Ihil-Bong Choi, Yeunhwa Gu, Tomohiro Kawamura, Yoshiya Toyoda, et al.
Background: Cancer patients receiving radiotherapy often experience fatigue and impaired quality of life (QOL). Many side effects of radiotherapy are believed to be associated with increased oxidative stress and inflammation due to the generation of reactive oxygen species during radiotherapy. Hydrogen can be administered as a therapeutic medical gas, has antioxidant properties, and reduces inflam
HypothesisHighlighted
MHID-5193561PMID: 196648842010Medical Hypotheses
Cong Liu, Jianguo Cui, Quan Sun, Jianming Cai
Hydrogen is the most abundant chemical element in the universe, however, it is seldom regarded as a therapeutic gas. Recent studies show that inhaled hydrogen gas (H2) has antioxidant and antiapoptotic activities that protect the brain against ischemia–reperfusion injury and stroke by selectively reducing hydroxyl and peroxynitrite radicals. It is also well known that more than a half of the ioniz
Animal StudyIn VitroHighlighted
MHID-1312487PMID: 332312662010Free Radical Research
Liren Qian, Fei CAO, Jianguo Cui, Yuecheng Huang, Xiaojian Zhou, Shulin Liu, et al.
It has been demonstrated that hydrogen can selectively reduce hydroxyl and peroxynitrite in vitro. Since most of the ionizing radiation-induced cellular damage is caused by hydroxyl radicals, this study was designed to test the hypoth- esis that hydrogen may be an effective radioprotective agent. This paper demonstrates that treating cells with hydrogen before irradiation could signifi cantly inhib
Hypothesis
MHID-5798200PMID: 212751142010West Indian Medical Journal
Liren Qian, Bailong Li, Jianming Cai, Fu Gao
Most ionizing radiation-induced damage is caused by radical oxygen species (ROS).
Some
radioprotectors, such as amifostine, exert radioprotective effects by scavenging radical oxygen species.
Recent studies show that hydrogen (H2) has antioxidant activities that protect the brain and intestine
against ischaemia-reperfusion injury and stroke by selectively reducing hydroxyl and peroxynitrite
radica
Clinical TrialObservational StudyHighlighted
MHID-8766045PMID: 202169472010Journal of Clinical Biochemistry and Nutrition
Atsunori Nakao, Yoshiya Toyoda, Prachi Sharma, Malkanthi Evans, Najla Guthrie
Metabolic syndrome is characterized by cardiometabolic risk factors that include obesity, insulin resistance, hypertension and dyslipidemia. Oxidative stress is known to play a major role in the pathogenesis of metabolic syndrome. The objective of this study was to examine the effectiveness of hydrogen rich water (1.5–2 L/day) in an open label, 8-week study on 20 subjects with potential metabolic
Animal StudyHighlighted
MHID-6761448PMID: 185630582009Neuropsychopharmacology
Kazufumi Nagata, Naomi Nakashima-Kamimura, Toshio Mikami, Ikuroh Ohsawa, Shigeo Ohta
We have reported that hydrogen (H2) acts as an efficient antioxidant by gaseous rapid diffusion. When water saturated with hydrogen (hydrogen water) was placed into the stomach of a rat, hydrogen was detected at several mM level in blood. Because hydrogen gas is unsuitable for continuous consumption, we investigated using mice whether drinking hydrogen water ad libitum, instead of inhaling hydroge
