Observational Study
MHID-31585802025Sport Sciences for Health
Nikola Todorovic, Jovan Kuzmanovic, Dejan Javorac, Sergej M Ostojic
Purpose Exercise induces transient physiological disruptions, including immune suppression and gastrointestinal (GI) disturbance. Molecular hydrogen (H₂), an endogenously produced gas with antioxidant and anti-inflammatory properties, may play a protective role in this context. While the therapeutic potential of exogenous H₂ has been widely explored, little is known about endogenous hydrogen respo
Literature Review
MHID-1191317PMID: 406196052025Advanced Science
Gangfeng Li, Hannan Cui, Ruixiao Fan, Guming Liu, Zishuo Hou, Yibo Zhang, et al.
The delivery of molecular hydrogen (H2) is increasingly recognized for its potential in precision immunomodulation, primarily through multiple pathways such as antioxidant action, modulation of inflammatory factors, and inhibition of apoptosis. These effects contribute to a balanced and functional immune system, highlighting the therapeutic promise of H2 in various inflammatory conditions. However, t
Literature ReviewHighlighted
MHID-45792272025International Journal of Molecular Sciences
Dominika Zajac, Monika Jampolska, Piotr Wojciechowski
Molecular hydrogen is gaining increasing attention as an antioxidant, anti-
inflammatory, and antiapoptotic agent. Once considered an inert gas, it reveals current
therapeutic potential among others in inflammatory diseases, cancer, and sports medicine,
among others. The present review aims to provide a consistent summary of the findings
of the last twenty years on the use of molecular hydrogen in
Literature ReviewHighlighted
MHID-4821613PMID: 339191462024Pul’monologiya
Alexander G. Chuchalin
The aim of the review was to examine the main characteristics of hydrogen ion metabolism and its hemostatic function in the human body. For diagnostic purposes, molecular hydrogen (H2) is considered a biological marker. The results of the analysis of therapeutic programs for the clinical use of hydrogen are presented. The use of H2 as a drug in the treatment of more than 170 diseases is also discu
Literature ReviewHighlighted
MHID-1339888PMID: 397659102024Antioxidants
Mikhail Yu. Artamonov, Felix A. Pyatakovich, Inessa A. Minenko
In regenerative medicine, mesenchymal stem cells (MSCs) have shown their importance and potential in tissue reconstruction and immune system modification. However, such cells’ potential is often diminished by factors such as oxidative stress, immune rejection, and inadequate engraftment. This review highlights the role of molecular hydrogen (H2) and cold atmospheric plasma (CAP) as adjunct therapi
Clinical Trial
MHID-8109346PMID: 390647852024Nutrients
Gengxin Dong, Haiyan Liu, Yunji Chen, Dapeng Bao, Wentao Xu, Junhong Zhou
Background: The diversity of blood biomarkers used to assess the metabolic mechanisms of hydrogen limits a comprehensive understanding of its effects on improving exercise performance. This study evaluated the impact of hydrogen-rich gas (HRG) on metabolites following sprint-interval exercise using metabolomics approaches, aiming to elucidate its underlying mechanisms of action.
Methods: Ten heal
In SilicoHighlighted
MHID-7592026PMID: 387844102024RSC Advances
Yun-Kyong Ri, Song-Ae Kim, Yun-Hyok Kye, Yu-Chol Jong, Myong-Su Kang, Chol-Jun Yu
Molecular hydrogen shows antioxidant activity and distinct efficacy towards vascular diseases, but the understanding of this is not yet satisfactory at the atomic level. In this work, we study the binding properties of H2 to the heme group in relation with other diatomic molecules (DMs), including O2, NO and CO, and their displacement reactions, using first-principles calculations. We carry out molec
Mechanisms ReviewHighlighted
MHID-3162417PMID: 386754292024Pharmaceuticals
Mikhail Yu. Artamonov, Tyler W. LeBaron, Felix A. Pyatakovich, Inessa A. Minenko
Stem cell therapy has emerged as a promising avenue for regenerative medicine, offering the potential to treat a wide range of debilitating diseases and injuries. Among the various types of stem cells, mesenchymal stem cells (MSCs) have garnered significant attention due to their unique properties and therapeutic potential. In recent years, researchers have been exploring novel approaches to enhan
Literature ReviewHighlighted
MHID-6653093PMID: 258736622024Journal of Plant Physiology and Metabolism
John T. Hancock
Gaseous hydrogen (H2) has emerged as a molecule that has a significant influence on the growth and development of plants, particularly if they are under stress. Often research has shown the ameliorating effects of H2 during drought, in the presence of heavy metals or salt, or during UV light irradiation. Postharvest, H2 has been shown to increase the quality of fruits and vegetables during storage
Literature ReviewHypothesisHighlighted
MHID-3205850PMID: 359678412022Frontiers in Cellular and Infection Microbiology
Sergej M Ostojic
The molecular footprints of COVID-19 occur everywhere, even reaching the family of biologically active gases and gasotransmitters. Besides nitric oxide and hydrogen sulfide, COVID-19 might also alter the homeostasis of dihydrogen (H2), another gaseous bioactive molecule produced endogenously by the human gut bacteria. Many studies have shown various alterations of the gut microbiota in patients wit
Hypothesis
MHID-81905412022Oxygen
John T. Hancock, Grace Russell, Tim J. Craig, Jennifer May, H. Ruth Morse, Jonathan S. Stamler
Hydrogen gas (molecular hydrogen, H2) has significant effects in a range of organisms, from plants to humans. Many inert gases have been reported to have similar effects, and such responses may be most pronounced when cells are stressed. Xenon (Xe), for example, is a well-known anesthetic. The direct targets of these gases, in most cases, remain elusive. Myoglobin and hemoglobin are known for their
Literature ReviewHighlighted
MHID-8010762PMID: 348346332021Plants
John T. Hancock, Tyler W. LeBaron, Jennifer May, Adam Thomas, Grace Russell
Despite being trialed in other regions of the world, the use of molecular hydrogen (H2) for enhanced plant growth and the postharvest storage of crops has yet to be widely accepted in the UK. The evidence that the treatment of plants and plant products with H2 alleviates plant stress and slows crop senescence continues to grow. Many of these effects appear to be mediated by the alteration of the a
Literature Review
MHID-5326803PMID: 349874192021Frontiers in Physiology
Yan Tian, Yafang Zhang, Yu Wang, Yunxi Chen, Weiping Fan, Jianjun Zhou, et al.
Molecular hydrogen (H2) is a colorless and odorless gas. Studies have shown that H2 inhalation has the therapeutic effects in many animal studies and clinical trials, and its application is recommended in the novel coronavirus pneumonia treatment guidelines in China recently. H2 has a relatively small molecular mass, which helps it quickly spread and penetrate cell membranes to exert a wide range
Literature ReviewHighlighted
MHID-5196947PMID: 342135002021Medical Gas Research
Eugene Iv. Nazarov, Igor Alb. Khlusov, Mami Noda
Among medical gases, including gases used therapeutically, this review discusses the comparative physiological activity of three gases – ozone (O3), xenon (Xe) and molecular hydrogen (H2), which together form representatives of three types of substances – typical oxidizing, inert, and typical reducing agents. Upon analysis of published and proprietary data, we concluded that these three medical ga
Literature Review
MHID-3461972PMID: 309702152019Canadian Journal of Physiology and Pharmacology
Tyler W. LeBaron, Ismail Laher, Branislav Kura, Jan Slezak
H2 has been clinically demonstrated to provide antioxidant and anti-inflammatory effects, which makes it an attractive agent in exercise medicine. Although exercise provides a multiplicity of benefits including decreased risk of disease, it can also have detrimental effects. For example, chronic high-intensity exercise in elite athletes, or sporadic bouts of exercise (i.e. noxious exercise) in unt
Literature ReviewMechanisms Review
MHID-7292103PMID: 310571052019Current Pharmaceutical Design
Toru Ishibashi
Background: Molecular hydrogen (H2) is now recognized as a therapeutic gas for the treatment of numerous diseases including neurodegenerative diseases, metabolic disorders, and inflammatory diseases. Non- polar, neutral H2 is assumed to have health benefits facilitated by its passive diffusion across the human body immediately after administration and is considered a safe therapeutic inert gas tha
Literature Review
MHID-1929560PMID: 317383892019Acta Biochimica et Biophysica Sinica
Geru Tao, Guohua Song, Shucun Qin
Ever since molecular hydrogen was first reported as a hydroxyl radical scavenger in 2007, the beneficial effect of hydrogen was documented in more than 170 disease models and human diseases including ischemia/reperfusion injury, metabolic syndrome, inflammation, and cancer. All these pathological damages are concomitant with overproduction of reactive oxygen species (ROS) where molecular hydrogen has
Clinical TrialHighlighted
MHID-4871667PMID: 309188322019Journal of Lifestyle Medicine
Tyler W. LeBaron, Abigail J. Larson, Shigeo Ohta, Toshio Mikami, Jordon Barlow, Josh Bulloch, et al.
Background: Clinical studies have reported hydrogen-rich water (HRW) to have therapeutic and ergogenic effects. The aim of this study was to determine the effect of acute supplementation with HRW on exercise performance as measured by VO2, respiratory exchange ratio (RER), heart rate (HR), and respiratory rate (RR).
Methods: Baseline levels of all exercise indices were determined in nineteen (4 f
Literature Review
MHID-1011283PMID: 312232852019International Journal of Biological Sciences
Peng Qiu, Yang Liu, Jin Zhang
Sepsis is a syndrome comprised of a series of life-threatening organ dysfunctions caused by a maladjusted body response to infection with no effective treatment. Molecular hydrogen is a new type of antioxidant with strong free radical scavenging ability, which has been demonstrated to be effective for treating various diseases, such as infection, trauma, poisoning, organ ischemia-reperfusion, meta
Literature Review
MHID-8766047PMID: 311002032019Canadian Journal of Physiology and Pharmacology
Mami Noda, Yuya Uemura, Yusuke Yoshii, Taichi Horita, Shota Takemi, Ichiro Sakata, et al.
Molecular hydrogen (H2) showed protection against various kinds of oxidative stress-
related diseases. First it was reported that the mechanism of therapeutic effects of H2 was
anti-oxidative effect due to inhibition of most cytotoxic reactive oxygen species (ROS),
hydroxy radical (•OH). However, after chronic administration of H2 in drinking water,
oxidative stress-induced nerve injury is signifi
