Animal StudyHighlighted
MHID-2777514PMID: 225876642012BMC Neuroscience
Zong Zhuang, Meng-liang Zhou, Wan-chun You, Lin Zhu, Chi-yuan Ma, Xue-Jun Sun, et al.
Background: Increasing experimental and clinical data indicate that early brain injury (EBI) after subarachnoid hemorrhage (SAH) largely contributes to unfavorable outcomes, and it has been proved that EBI following SAH is closely associated with oxidative stress and brain edema. The present study aimed to examine the effect of hydrogen, a mild and selective cytotoxic oxygen radical scavenger, on
Animal StudyHighlighted
MHID-2488306PMID: 220408782011Biological & Pharmaceutical Bulletin
Kyung Su YOON, Xue Zhu HUANG, Yang Suk YOON, Soo-Ki Kim, Soon Bong SONG, Byung Soo CHANG, et al.
Electrolyzed reduced water (ERW), functional water, has various beneficial effects via antioxidant mecha-
nism in vivo and in vitro. However there is no study about beneficial effects of ERW bathing. This study aimed to
determine the effect of ERW bathing on the UVB-induced skin injury in hairless mice. For this purpose, mice
were irradiated with UVB to cause skin injury, followed by individually ta
Animal StudyHighlighted
MHID-2530014PMID: 214483402011International Journal of Biological Sciences
Luqian Zhao, Chuanfeng Zhou, Jian Zhang, Fu Gao, Bailong Li, Yunhai Chuai, et al.
Ionizing radiation (IR) is a well-known carcinogen, however the mechanism of radiation in- duced thymic lymphoma is not well known. Moreover, an easy and effective method to protect mice from radiation induced thymic lymphoma is still unknown. Hydrogen, or H2, is seldom regarded as an important agent in medical usage, especially as a therapeutic gas. Here in this study, we found that H2 protects m
HypothesisHighlighted
MHID-49572952011Medical Science Monitor
Yunhai Chuai, Luqian Zhao, Jin Ni, Ding Sun, Jianguo Cui, Bailong Li, et al.
Radiotherapy is an important modality of cancer treatment. Radiation pneumonitis is a major obstacle to increasing the radiation dose in radiotherapy, and it is important to prevent this radiation-induced complication. Recent studies show that hydrogen has a potential as an effective and safe radioprotective agent by selectively reducing hydroxyl and peroxynitrite radicals. Since most of the ioniz
In VitroHighlighted
MHID-98352102010Nuclear Technology & Radiation Protection
Liren Qian, Bailong Li, Fei CAO, Yuecheng Huang, Shulin Liu, Jianming Cai, et al.
Hydroxyl radicals play an important role in ionizing radiation-induced cellular damage, while hydrogen can selectively reduce hydroxyl radicals in vitro. This study was designed to test the hypothesis that hydrogen-rich PBS may be an effective radioprotective agent in vitro. Com pared to cells pretreated with out hydrogen, we demonstrated that treating cells with hydrogen-rich PBS be fore irradiat
HypothesisHighlighted
MHID-5193561PMID: 196648842010Medical Hypotheses
Cong Liu, Jianguo Cui, Quan Sun, Jianming Cai
Hydrogen is the most abundant chemical element in the universe, however, it is seldom regarded as a therapeutic gas. Recent studies show that inhaled hydrogen gas (H2) has antioxidant and antiapoptotic activities that protect the brain against ischemia–reperfusion injury and stroke by selectively reducing hydroxyl and peroxynitrite radicals. It is also well known that more than a half of the ioniz
Animal StudyIn VitroHighlighted
MHID-1312487PMID: 332312662010Free Radical Research
Liren Qian, Fei CAO, Jianguo Cui, Yuecheng Huang, Xiaojian Zhou, Shulin Liu, et al.
It has been demonstrated that hydrogen can selectively reduce hydroxyl and peroxynitrite in vitro. Since most of the ionizing radiation-induced cellular damage is caused by hydroxyl radicals, this study was designed to test the hypoth- esis that hydrogen may be an effective radioprotective agent. This paper demonstrates that treating cells with hydrogen before irradiation could signifi cantly inhib
Hypothesis
MHID-5798200PMID: 212751142010West Indian Medical Journal
Liren Qian, Bailong Li, Jianming Cai, Fu Gao
Most ionizing radiation-induced damage is caused by radical oxygen species (ROS).
Some
radioprotectors, such as amifostine, exert radioprotective effects by scavenging radical oxygen species.
Recent studies show that hydrogen (H2) has antioxidant activities that protect the brain and intestine
against ischaemia-reperfusion injury and stroke by selectively reducing hydroxyl and peroxynitrite
radica
Animal StudyHighlighted
MHID-2859819PMID: 211161022010Journal of Radiation Research
Liren Qian, Fei CAO, Jianguo Cui, Yicun Wang, Yuecheng Huang, Yunhai Chuai, et al.
Most ionizing radiation-induced damage is caused by hydroxyl radicals, and the selective reduction
of hydroxyl by hydrogen in vitro has been demonstrated previously. Irradiation of the heart can cause
chronic cardiac disease. This study was designed to test the hypothesis that hydrogen-rich water (pure
water saturated with molecular hydrogen), which is easy to use, induces cardioprotection against
Animal StudyHighlighted
MHID-9017895PMID: 208883922010Neuroscience Letters
Ying Lin, Akinori Kashio, Takashi Sakamoto, Keigo Suzukawa, Akinobu Kakigi, Tatsuya Yamasoba
It has been shown that molecular hydrogen acts as a therapeutic and preventive antioxidant by selectively reducing the hydroxyl radical, the most cytotoxic of the reactive oxygen species. In the present study, we tested the hypothesis that acoustic damage in guinea pigs can be attenuated by the consumption of molecular hydrogen. Guinea pigs received normal water or hydrogen-rich water for 14 days
Clinical TrialObservational Study
MHID-1491336PMID: 199307632010British Journal of Nutrition
Min Li, Jian-Hua Piao, Yuan Tian, Wei-Dong Li, Ke-Ji Li, Xiao-Guang Yang
Consumption of resistant starch (RS)-enriched foods is associated with decrease in the postprandial glycaemic and insulinaemic responses, accompanied by the production of fermentation-related gases in the large bowel. The present study aimed to determine the postprandial glycaemic and insulinaemic responses to the GM RS-enriched rice and the fermentation-related production of H2 in young and healt
Literature Review
MHID-2963789PMID: 212269922010The Journal of International Medical Research
Y Hong, S Chen, J-M Zhang
Oxidative stress is implicated in the pathogenesis of many diseases; however, currently used antioxidants have a high toxicity that constrains administration to a narrow window of therapeutic dosage. There is a clear need for more effective and safer antioxidants. Diatomic hydrogen (H2) was proposed as a novel antioxidant that selectively reduces levels of toxic reactive-oxygen species. Recently,
Animal StudyHighlighted
MHID-3863264PMID: 203516282010Shock
Keliang Xie, Yonghao Yu, Zishen Zhang, Wenbo Liu, Yuping Pei, Lize Xiong, et al.
Sepsis/multiple organ dysfunction syndrome is the leading cause of death in critically ill patients. Recently, it has been suggested that hydrogen gas (H2) exerts a therapeutic antioxidant activity by selectively reducing hydroxyl radical (&OH, the most cytotoxic reactive oxygen species). We have found that H2 inhalation significantly improved the survival rate and organ damage of septic mice with
Animal StudyHighlighted
MHID-7407969PMID: 195968252009Experimental Biology and Medicine
QIANG SUN, ZHIMIN KANG, JIANMEI CAI, WENWU LIU, YUN LIU, John H Zhang, et al.
Protective effect of hydrogen (H2) gas on cardiac ischemia-reperfusion (I/R) injury has been demonstrated previously. This study was designed to test the hypothesis that hydrogen-rich saline (saline saturated with molecular hydrogen), which is easy to use, induces cardioprotection against ischemia (30 min) and reperfusion (24 h) injury in rats. Adult male Sprague-Dawley rats underwent 30-min occlu
Animal StudyHighlighted
MHID-1488636PMID: 192522952009Biological & Pharmaceutical Bulletin
Kyu Jae LEE, Dan JIN, Byung Soo CHANG, Yung Chien TENG, Dong Heui KIM
Electrolyzed reduced water (ERW) is widely used for drinking by people in Asia. The purpose of this study was to examine the immunological effect of ERW on the immunity of animals by supplying ERW to C57BL/6 mice infected with Echinostoma hortense metacercariae. In the non-infected groups, interleukin (IL)-4 (p0.001), IL-5, IL-10, IL-1b, tumor necrosis factor (TNF)-a and immunoglobulin (Ig) A exp
